Diabetic Striatopathy in Childhood: A Case Report

Abstract

Diabetic striatopathy is a well-known complication of diabetes in adults. To our knowledge, only 2 cases have been reported in children. We here report the case of a teenager in whom diabetic striatopathy was revealed by the subacute appearance of hemichorea-hemiballism in the context of weight loss, polyuria, and polydipsia. Glycemia control allowed rapid clinical recovery despite established striatal lesions documented on MRI. We also discuss current hypotheses about pathophysiological processes underlying this entity

Diabetes Mellitus: A Review on Pathophysiology, Current Status of Oral Pathophysiology, Current Status of Oral Medications and Future Perspectives

“…In those cases along with weight loss, polyuria, and polydipsia was reported hemichorea-hemiballism that was receded after glucose control 27 . Among others taking right clinical history of a patient and not only the lean on the lab results for diabetic patients is quite important.…”

Nonketotic Hyperglycemic Chorea in a 10-Year-Old Asian Boy with Diabetes Mellitus

“…Nonketotic hyperglycemic chorea-ballism (NKHCB) has been well described in older Asian females [1][2][3][4] and rarely in children. 5,6 There were six previous case reports involving children and adolescents (►Table 2). 2,5,[7][8][9][10] The cases were predominantly in adolescents with abnormalities on imaging studies.…”

“…5,6 There were six previous case reports involving children and adolescents (►Table 2). 2,5,[7][8][9][10] The cases were predominantly in adolescents with abnormalities on imaging studies.…”

“…11,12 NKHCB, also known as diabetic striatopathy (DS) typically presents with hyperglycemia, hemichorea-hemiballism and abnormalities on brain MRI. 3,5 Although first described by Bedwell in 1960, 13 the first pediatric case of NKHCB was described five decades later by Mihai et al She described a 15-year-old girl with hemichorea, new onset T1DM without ketosis, and abnormality on brain MRI. 7 The youngest reported patient was an 8-yearold boy with new onset T1DM, hemichorea-hemiballism, and contralateral lesion in putamen on brain MRI.…”

A few thoughts on diabetic striatopathy – case report and short review

“…For example, Das et al reported the occurence of Ds in two young males with diabetic ketoacidosis. There have been only a few cases of Ds so far in children, including one in a teenager with subacute onset of hemichorea accompanied by weight loss, polydipsia and polyuria [10].…”