Diabetic Serum Inhibits Osteoblast Adhesion to Titanium Surface Through Advanced Glycation End Products: An In Vitro Study

Fiorellini, Joseph P.; Sourvanos, Dennis; Crohin, Constant; Crohin, Michele; Chang, Jane J.; Mattos, Marcelo; Ko, Kang I

doi:10.11607/jomi.8114

Cited by 2 publications

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“…However, experiments have shown that this pathway is inhibited in osteoblasts on titanium surfaces and prevents cell attachment and functions through osseointegration ( Ma et al, 2014 ). Diabetes-related osteoporosis is partly due to the formation and accumulation of advanced glycation end products, which can also inhibit the adhesion of osteoblasts to the titanium surface ( Fiorellini et al, 2020 ). Diabetes also reportedly hampers osseointegration by delaying the expression of fibronectin and integrin α5β1 ( Liu et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Hormone and implant osseointegration: Elaboration of the relationship among function, preclinical, and clinical practice

Yin²,

Sun³

et al. 2022

Front. Mol. Biosci.

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As clusters of peptides or steroids capable of high-efficiency information transmission, hormones have been substantiated to coordinate metabolism, growth, development, and other physiological processes, especially in bone physiology and repair metabolism. In recent years, the application of hormones for implant osseointegration has become a research hotspot. Herein, we provide a comprehensive overview of the relevant reports on endogenous hormones and their corresponding supplementary preparations to explore the association between hormones and the prognosis of implants. We also discuss the effects and mechanisms of insulin, parathyroid hormone, melatonin, vitamin D, and growth hormone on osseointegration at the molecular and body levels to provide a foothold and guide future research on the systemic conditions that affect the implantation process and expand the relative contraindications of the implant, and the pre-and post-operative precautions. This review shows that systemic hormones can regulate the osseointegration of oral implants through endogenous or exogenous drug-delivery methods.

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Section: Introductionmentioning

confidence: 99%

Hormone and implant osseointegration: Elaboration of the relationship among function, preclinical, and clinical practice

Yin²,

Sun³

et al. 2022

Front. Mol. Biosci.

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A review: strategies to reduce infection in tantalum and its derivative applied to implants

et al. 2023

Biomedical Engineering / Biomedizinische Technik

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Implant-associated infection is the main reasons for implant failure. Titanium and titanium alloy are currently the most widely used implant materials. However, they have limited antibacterial performance. Therefore, enhancing the antibacterial ability of implants by surface modification technology has become a trend of research. Tantalum is a potential implant coating material with good biological properties. With the development of surface modification technology, tantalum coating becomes more functional through improvement. In addition to improving osseointegration, its antibacterial performance has also become the focus of attention. In this review, we provide an overview of the latest strategies to improve tantalum antibacterial properties. We demonstrate the potential of the clinical application of tantalum in reducing implant infections by stressing its advantageous properties.

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Diabetic Serum Inhibits Osteoblast Adhesion to Titanium Surface Through Advanced Glycation End Products: An In Vitro Study

Cited by 2 publications

References 0 publications

Hormone and implant osseointegration: Elaboration of the relationship among function, preclinical, and clinical practice

Hormone and implant osseointegration: Elaboration of the relationship among function, preclinical, and clinical practice

A review: strategies to reduce infection in tantalum and its derivative applied to implants

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