Diabetic retinopathy

Porta, Massimo; Bandello, Francesco

doi:10.1007/s00125-002-0990-7

Cited by 169 publications

(31 citation statements)

References 122 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diabetic retinopathy is widely regarded as a microvascular pathology [2] characterized by clinical signs such as neovascularization and macular edema [3]. However, it is currently recognized to be a neurovascular disease with neuronal impairment that precedes vascular damage.…”

Section: Introductionmentioning

confidence: 99%

Clock Genes and Behavioral Responses to Light Are Altered in a Mouse Model of Diabetic Retinopathy

et al. 2014

View full text Add to dashboard Cite

There is increasing evidence that melanopsin-expressing ganglion cells (ipRGCs) are altered in retinal pathologies. Using a streptozotocin-induced (STZ) model of diabetes, we investigated the impact of diabetic retinopathy on non-visual functions by analyzing ipRGCs morphology and light-induced c-Fos and Period 1–2 clock genes in the central clock (SCN). The ability of STZ-diabetic mice to entrain to light was challenged by exposure animals to 1) successive light/dark (LD) cycle of decreasing or increasing light intensities during the light phase and 2) 6-h advance of the LD cycle. Our results show that diabetes induces morphological changes of ipRGCs, including soma swelling and dendritic varicosities, with no reduction in their total number, associated with decreased c-Fos and clock genes induction by light in the SCN at 12 weeks post-onset of diabetes. In addition, STZ-diabetic mice exhibited a reduction of overall locomotor activity, a decrease of circadian sensitivity to light at low intensities, and a delay in the time to re-entrain after a phase advance of the LD cycle. These novel findings demonstrate that diabetes alters clock genes and behavioral responses of the circadian timing system to light and suggest that diabetic patients may show an increased propensity for circadian disturbances, in particular when they are exposed to chronobiological challenges.

show abstract

Section: Introductionmentioning

confidence: 99%

Clock Genes and Behavioral Responses to Light Are Altered in a Mouse Model of Diabetic Retinopathy

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Additional factors such as microalbuminuria, hyperlipidemia and ocular perfusion pressure influence diabetic disease progression as well [88]. …”

Section: Hypothetical Pathogenesis Of Pdvrmentioning

confidence: 99%

“…Diabetic retinopathy is one of the leading causes of blindness in the Western world [31, 55, 75, 88, 103]. Diabetic retinopathy may be subdivided into a nonproliferative (non-PDR) and a proliferative (PDR) form.…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis and Classification of Proliferative Diabetic Vitreoretinopathy

Kroll¹,

Rodrigues²,

Hoerle³

2007

Ophthalmologica

View full text Add to dashboard Cite

Purpose: To review the current knowledge regarding the pathogenesis of proliferative diabetic vitreoretinopathy (PDVR) and to present recommendations for its clinical staging. Design: Focused literature review and authors’ clinical experience. Results: Although several biochemical mediators may be responsible for the pathogenesis of PDVR, no common biochemical pathway exists. Of those mediators, vascular endothelial growth factor is the one most studied so far. However, since in proliferative diabetic retinopathy (PDR) the thickened posterior vitreous cortex is one of the main factors in the development of proliferations, a consequent shrinkage of the posterior vitreous cortex leads to hemorrhages and tractive retinal detachments. Therefore, PDR should be called PDVR. In consequence, the authors present a new morphological classification of PDVR. Conclusions: There is no consensus about the biochemical pathway responsible for the progression of PDVR. Although several classifications are described in the literature, the classification suggested here is important in the judgment of, the communication about and the therapy of diabetic retinopathy. Furthermore, it is the only reliable classification for predicting the surgical outcome in diabetics.

show abstract

“…Diabetic retinopathy (DR) represents a common complication of type 2 diabetes mellitus, and remains one of the leading causes of visual impairment and blindness [1]. DR is characterized by damage and occlusions in small vessels, leading to the formation of pathological retinal lesions such as microaneurysms, haemorrhages and hard and soft exudates.…”

Section: Introductionmentioning

confidence: 99%