Diabetic neuropathy in patients with "Latent Autoimmune Diabetes of the Adults" (LADA) compared with patients with type 1 and type 2 diabetes

Abstract

LADA patients had fewer features of diabetic neuropathy than type 2 diabetes patients in the early stages of disease, thus being more similar to classical type 1 diabetes patients who normally develop diabetic neuropathy rather late.

Latent autoimmune diabetes in adults (LADA) should be less latent

“…The frequency of retinopathy and nephropathy in LADA is similar to that in type 2 diabetes; neuropathy appears to be uncommon initially but increases with duration of disease [51]. The frequency of retinopathy (51%), nephropathy (microalbuminuria) (27%) and neuropathy (29%) was similar in LADA patients and patients with type 1 diabetes diagnosed for more than 10 years; type 1 diabetic patients had significantly more retinopathy (76%) but less neuropathy (13%) [50].…”

Evaluating peripheral nerve function in asymptomatic patients with type 2 diabetes or latent autoimmune diabetes of adults (LADA): results from nerve conduction studies

“…However, comparative studies are limited in humans (Baum et al, 2003;Isomaa et al, 1999;Lohmann et al, 2001). With the largest sample size to date, this study cross-sectional surveyed 1635 patients with LADA or T2DM who were categorized into 3 duration groups.…”

“…The prevalence of DPN did not differ between the two groups (29% vs. 27%). By comparison, in a study comprising 14 patients with LADA and 14 with T2DM, Baum et al (2003) demonstrated that electrophysiological parameters showed a trend toward better outcomes in LADA than in T2DM. However, these studies were compromised by small sample sizes.…”

“…Although enormous efforts have been put into the research in DPN, only few studies have investigated DPN features in LADA (Lohmann et al, 2001), and data are even more limited and inconsistent regarding comparisons of LADA with other forms of diabetes (Baum et al, 2003;Isomaa et al, 1999). For instance, Isomaa et al (1999) examined the clinical characteristics of 59 patients with LADA and 59 with T2DM.…”

Small and large fiber neuropathy in those with type 1 and type 2 diabetes: a 5‐year follow‐up study

“…In an epidemiological study the risk of painful neuropathy in type 2 diabetes was reported to be double that found in type 1 (Abbott et al, ) . Other studies have also demonstrated a higher prevalence of neuropathy in those with diabetes type 2 (Baum et al, ; Kästenbauer et al, ; Ziegler et al, ) including more depletion of intraepidermal nerve fibers in asymptomatic subjects (Ragé et al, ) . In another epidemiological study of patients with adult diabetes and microvascular complications, occurrence of peripheral neuropathy did not differ between those with diabetes type 1 and type 2 (Happich et al, ) .…”