Diabetic neuropathy in Mauritius: prevalence and risk factors

Shaw, Jonathan E.; Hodge, Allison; Courten, Maximilian de; Dowse, Gary K.; Gareeboo, H.; Tuomilehto, Jaakko; Alberti, K. G. M. M.; Zimmet, Paul

doi:10.1016/s0168-8227(98)00100-4

Cited by 63 publications

(75 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a population study in Mauritius, height was a significant (p < 0.001) independent risk factor of DSPN, increasing its prevalence by 36% for every 5 cm increment (odds ratio (OR): 1.36, 95% confidence interval (CI): 1.19-1.57) in the crosssectional analysis [14]. In the same study, prospective data confirmed this association (OR: 1.23, 95% CI: 1.03-1.45 per 5 cm, p = 0.02) [14]. By contrast, Franklin et al found no association between height and prevalence of DSPN in a population study in Southern Colorado [51].…”

Section: Heightmentioning

confidence: 99%

“…In both diabetes types, the association of DSPN with diabetes duration is independent of patients' age [1,[11][12][13][14][15]. Although the exact prevalence of DSPN differs according to the diagnostic methodology used and the population selected (for example, hospitalbased vs. outpatient-based vs. community-based) [1], its association with diabetes duration remains significant [1,[11][12][13][14][15][16][17][18].…”

Section: Duration Of Diabetesmentioning

confidence: 99%

“…However, there is an important caveat in these observations. As age per se causes a progressive deterioration in neurological functions, independent of diabetes, the symptoms call for a differentiated interpretation [14,52]. Delcourt et al carried out an adjustment for age and found that DSPN no longer correlated with age [22].…”

Section: Agementioning

confidence: 99%

“…Evidence for an association of DSPN with height comes from studies in both diabetes types [11][12][13][14]26]. In a population study in Mauritius, height was a significant (p < 0.001) independent risk factor of DSPN, increasing its prevalence by 36% for every 5 cm increment (odds ratio (OR): 1.36, 95% confidence interval (CI): 1.19-1.57) in the crosssectional analysis [14]. In the same study, prospective data confirmed this association (OR: 1.23, 95% CI: 1.03-1.45 per 5 cm, p = 0.02) [14].…”

Section: Heightmentioning

confidence: 99%

“…More recently, a 6-year follow-up study of 48 Korean patients revealed that reduced high-density lipoprotein cholesterol (HDLc) (OR: 5.292, 95% CI: 1.001-27.989, p = 0.05) and high triglycerides (OR: 6.129, 95% CI: 1.057-35.528, p = 0.043) significantly increased the risk of DSPN, after adjusting for age and gender [58]. On the other hand, there is also some evidence against the association of DSPN with serum lipids [14,24].…”

Section: Dyslipidemiamentioning

confidence: 99%

See 4 more Smart Citations

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

2015

View full text Add to dashboard Cite

■ AbstractDistal symmetric sensorimotor polyneuropathy (DSPN) is the most common neurological manifestation in diabetes. Major risk factors of DSPN include diabetes duration, hyperglycemia, and age, followed by prediabetes, hypertension, dyslipidemia, and obesity. Height, smoking, insulin resistance, hypoinsulinemia, and others represent an additional risk. Importantly, hyperglycemia, hypertension, dyslipidemia, obesity, and smoking are modifiable. Stringent glycemic control has been shown to be effective in type 1, but not to the same extent in type 2 diabetes. Antilipidemic treatment, especially with fenofibrate, and multi-factorial intervention have produced encouraging results, but more experience is necessary. The major comorbidities of DSPN are depression, autonomic neuropathy, peripheral artery disease, cardiovascular disease, nephropathy, retinopathy, and medial arterial calcification. Knowledge of risk factors and comorbidities has the potential to enrich the therapeutic strategy in clinical practice as part of the overall medical care for patients with neuropathy. This article provides an updated overview of DSPN risk factors and comorbidities.

show abstract

Section: Heightmentioning

confidence: 99%

Section: Duration Of Diabetesmentioning

confidence: 99%

Section: Agementioning

confidence: 99%

Section: Heightmentioning

confidence: 99%

Section: Dyslipidemiamentioning

confidence: 99%

See 3 more Smart Citations

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

2015

View full text Add to dashboard Cite

show abstract

Diabetic Neuropathy

2006

Wiley Handbook of Current and Emerging Drug Therapies

View full text Add to dashboard Cite

An NMR and Molecular Modeling Study of Carbosilane‐Based Dendrimers Functionalized with Phenolic Groups or Titanium Complexes at the Periphery

Welch

Arévalo

Turner

et al. 2005

Chemistry A European J

View full text Add to dashboard Cite

Dendrimers are modified polymers whose architecture is defined by the presence of a central atom or core with multiple branches. These molecules lend themselves to a variety of architectures and uses, including drug delivery and catalysis. The study of the molecular conformations and shapes of dendritic molecules is necessary but not yet routine. Here we present an NMR and molecular modeling study of a series of carbosilane dendrimers, namely 1G-{(CH2)3[C6H3(OMe)]OH}4 (1), 2G-{(CH2)3[C6H3(OMe)]OH}8 (2), and 2G-{(CH2)3[C6H3(OMe)]O[Ti(C5H5)Cl2]}8 (3). Various two-dimensional NMR techniques were used to completely assign the 1H and 13C resonances of molecules 1-3. This information was used, in conjunction with 1H and 13C spin-lattice relaxation measurements, to assess the chain motion of the molecules. The NMR data were also compared with 1-ns molecular dynamics (MD) simulations of 1 and 2 using the MMFF94 force field. The results indicate that these dendrimers possess a core that is motionally decoupled from the rest of the dendrimer, with flexible arm segments that extend from the core. The addition of eight functionalized titanium groups to the ends of the dendrimer chains of 2 to yield molecule 3 serves to further restrict chain motion.

show abstract

Diabetic neuropathy in Mauritius: prevalence and risk factors

Cited by 63 publications

References 25 publications

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

Diabetic Neuropathy

An NMR and Molecular Modeling Study of Carbosilane‐Based Dendrimers Functionalized with Phenolic Groups or Titanium Complexes at the Periphery

Contact Info

Product

Resources

About