Diabetic neuropathy: a risk factor for severe COVID-19?

Pitocco, Dario; Viti, Luca; Santoliquido, Angelo; Tartaglione, Linda; Leo, Mauro Di; Bianchi, Antonio; Caputo, Salvatore; Pontecorvi, Alfredo

doi:10.1007/s00592-020-01658-7

Cited by 7 publications

(9 citation statements)

References 5 publications

(8 reference statements)

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“…Additionally, cardiac autonomic neuropathy is significantly associated with decreased diffusing capacity of carbon monoxide (DLCO) ( Pitocco et al, 2008 ). The autonomic nervous system also provides negative feedback during an inflammatory response to decrease macrophage production of inflammatory cytokines ( Pitocco et al, 2021 ).…”

Section: Diabetes and Covid-19 Outcomesmentioning

confidence: 99%

“…As previously mentioned, the pro-inflammatory ‘cytokine storm’ is a hallmark of severe COVID-19. Pitocco et al (2021) suggest diabetic autonomic neuropathy may lead to impaired negative feedback of the inflammatory response. This may, in part, contribute to the excessive inflammation in COVID-19 infection leading to more sever forms of the disease ( Pitocco et al, 2021 ).…”

Section: Microvascular Complications Of Diabetes As a Risk Factor For Severe Covid-19mentioning

confidence: 99%

“… Pitocco et al (2021) suggest diabetic autonomic neuropathy may lead to impaired negative feedback of the inflammatory response. This may, in part, contribute to the excessive inflammation in COVID-19 infection leading to more sever forms of the disease ( Pitocco et al, 2021 ). Studies investigating the association between diabetic neuropathy and COVID-19 severity are required to confirm this hypothesis.…”

Section: Microvascular Complications Of Diabetes As a Risk Factor For Severe Covid-19mentioning

confidence: 99%

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What is the impact of microvascular complications of diabetes on severe COVID-19?

Basra

Whyte

Karalliedde

et al. 2022

Microvascular Research

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Evidence suggests severe coronavirus disease-19 (COVID-19) infection is characterised by pulmonary and systemic microvasculature dysfunction, specifically, acute endothelial injury, hypercoagulation and increased capillary permeability. Diabetes, which is also characterised by vascular injury in itself, confers an increased risk of adverse COVID-19 outcomes. It has been suggested that pre-existing endothelial dysfunction and microvascular disease in diabetes will exacerbate the vascular insults associated with COVID-19 and thus lead to increased severity of COVID-19 infection. In this article, we evaluate the current evidence exploring the impact of microvascular complications, in the form of diabetic retinopathy and nephropathy, in individuals with COVID-19 and diabetes. Future insights gained from exploring the microvascular injury patterns and clinical outcomes may come to influence care delivery algorithms for either of these conditions.

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Section: Diabetes and Covid-19 Outcomesmentioning

confidence: 99%

Section: Microvascular Complications Of Diabetes As a Risk Factor For Severe Covid-19mentioning

confidence: 99%

Section: Microvascular Complications Of Diabetes As a Risk Factor For Severe Covid-19mentioning

confidence: 99%

See 1 more Smart Citation

What is the impact of microvascular complications of diabetes on severe COVID-19?

Basra

Whyte

Karalliedde

et al. 2022

Microvascular Research

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Section: Diabetic Neuropathy and Covid-19mentioning

confidence: 99%

“…71 It has been hypothesized that diabetic neuropathy could be a significant risk factor for severe COVID-19 due to an impairment of the autonomic nervous system and the inflammatory reflex resulting in a pro-inflammatory state in diabetic patients with COVID-19. 72 It has also been suggested that because of the cytokine alterations in patients with diabetic foot disease, a bidirectional relationship between COVID-19 and diabetic foot disease may exist. 73 We have recently shown a widespread sensory neuropathy with loss of taste and smell and abnormal thermal thresholds in four diabetic patients hospitalized with severe COVID-19, without a prior diagnosis of diabetic neuropathy.…”

Section: Diabetic Neuropathy and Covid-19mentioning

confidence: 99%

COVID-19 and the hidden threat of diabetic microvascular complications

Zaghloul

Malik

2022

Therapeutic Advances in Endocrinology

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The coronavirus disease 2019 (COVID-19) pandemic affected at least 200 million individuals worldwide and resulted in nearly 5 million deaths as of October 2021. According to the latest data from the International Diabetes Federation (IDF) in 2021, the diabetes pandemic has affected 537 million people and is associated with 6.7 million deaths. Given the high prevalence of both diabetes and COVID-19 and common pathological outcomes, a bidirectional relationship could have a catastrophic outcome. The increased risk of COVID-19 in those with obesity and diabetes and higher morbidity and mortality has received considerable attention. However, little attention has been given to the relationship between COVID-19 and microvascular complications. Indeed, microvascular complications are associated with an increased risk of cardiovascular disease (CVD) and mortality in diabetes. This review assesses the evidence for an association between diabetic microvascular complications (neuropathy, nephropathy, and retinopathy) and COVID-19. It draws parallels between the pathological changes occurring in the microvasculature in both diseases and assesses whether microvascular disease is a prognostic factor for COVID-19 outcomes in diabetes.

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Exploration of the common pathogenic link between COVID‐19 and diabetic foot ulcers: An in silico approach

Cai,

Yang,

Shi

et al. 2023

Health Science Reports

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Background and AimsThe Coronavirus Disease‐19 (COVID‐19) is posing an ongoing threat to human health. Patients of diabetic foot ulcer (DFU) are susceptible to COVID‐19‐induced adverse outcomes. Nevertheless, investigations into their mutual molecular mechanisms have been limited to date. In the present work, we tried to uncover the shared pathogenesis and regulatory gene targets of COVID‐19 and DFU.MethodsIn this study, we chose GSE161281 as the COVID‐19 data set, which contained severe acute respiratory syndrome coronavirus 2 infected human induced embryonic stem cell‐derived peripheral neurons (n = 2) with uninfected controls (n = 2). The GSE134431 designated as the DFU data set, comprising full‐thickness DFU (n = 13) and diabetic foot skin (n = 8) samples from diabetic patients. The differential expressed genes (DEGs) were identified from GSE161281 and GSE134431, and the common DEGs between COVID‐19 and DFU were extracted. Multifactor regulatory network and co‐expression network of the common DEGs were analyzed, along with candidate drug prediction.ResultsAltogether, six common DEGs (dickkopf‐related protein 1 [DKK1], serine proteinase inhibitor A3 [SERPINA3], ras homolog family member D [RHOD], myelin protein zero like 3 [MPZL3], Claudin‐11 [CLDN11], and epidermal growth factor receptor pathway substrate 8‐like 1 [EPS8L1]) were found between COVID‐19 and DFU. Functional analyses indicated that pathways of apoptotic and Wnt signaling may contribute to progression of COVID‐19. Gene co‐expression network implied the shared pathways of immune regulation and cytokine response participated collectively in the development of DFU and COVID‐19. A multifactor regulatory network was constructed integrating the corresponding microRNAs (miRNAs) and transcription factors. Additionally, we proposed potential drug objects for the combined therapy.ConclusionOur study revealed the shared molecular mechanisms underlying COVID‐19 and DFU. The identified pivotal targets and common pathways can provide new perspectives for further research and assist the development of management strategies in patients of DFU complicated with COVID‐19.

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Diabetic neuropathy: a risk factor for severe COVID-19?

Cited by 7 publications

References 5 publications

What is the impact of microvascular complications of diabetes on severe COVID-19?

What is the impact of microvascular complications of diabetes on severe COVID-19?

COVID-19 and the hidden threat of diabetic microvascular complications

Exploration of the common pathogenic link between COVID‐19 and diabetic foot ulcers: An in silico approach

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