Diabetic Neuropathic Pain: Real World Treatment Options

Lindsay, Tammy J.; Vitrikas, Kirsten; Temporal, Michael; Herndon, Christopher M.

doi:10.4137/cmt.s7266

Cited by 4 publications

(10 citation statements)

References 110 publications

(127 reference statements)

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“…The newer, less dopamine selective antipsychotics was supported by some animal studies consistent with clinical trials [104]. These compounds may induce negative metabolic effects such as weight gain and insulin resistance [105]. …”

Section: Treatment Of Dnmentioning

confidence: 99%

“…These agents are all potent voltage-gated sodium channel antagonists and perhaps are less used in DN [105]. Mexiletine, lidocaine, and tocainide have all shown benefits for painful DN in smaller RCTs.…”

Section: Treatment Of Dnmentioning

confidence: 99%

“…Mexiletine, lidocaine, and tocainide have all shown benefits for painful DN in smaller RCTs. Although tocainide has positive effects, but caution is needed for its cardiotoxicity [105]. Mexiletine has not been found effective [103].…”

Section: Treatment Of Dnmentioning

confidence: 99%

“…Mexiletine has not been found effective [103]. The easiest method to incorporate the utility of the anesthetic/antiarrhythmics in patients with painful DN is the use of 5% lidocaine patches [105]. …”

Section: Treatment Of Dnmentioning

confidence: 99%

“…Isosorbide dinitrate nasal spray and glyceryl trinitrate transdermal patches have shown positive effects in painful DN [105]. …”

Section: Treatment Of Dnmentioning

confidence: 99%

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Diabetic Neuropathy and Oxidative Stress: Therapeutic Perspectives

Hosseini

Abdollahi

2013

Oxidative Medicine and Cellular Longevity

179

124

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Diabetic neuropathy (DN) is a widespread disabling disorder comprising peripheral nerves' damage. DN develops on a background of hyperglycemia and an entangled metabolic imbalance, mainly oxidative stress. The majority of related pathways like polyol, advanced glycation end products, poly-ADP-ribose polymerase, hexosamine, and protein kinase c all originated from initial oxidative stress. To date, no absolute cure for DN has been defined; although some drugs are conventionally used, much more can be found if all pathophysiological links with oxidative stress would be taken into account. In this paper, although current therapies for DN have been reviewed, we have mainly focused on the links between DN and oxidative stress and therapies on the horizon, such as inhibitors of protein kinase C, aldose reductase, and advanced glycation. With reference to oxidative stress and the related pathways, the following new drugs are under study such as taurine, acetyl-L-carnitine, alpha lipoic acid, protein kinase C inhibitor (ruboxistaurin), aldose reductase inhibitors (fidarestat, epalrestat, ranirestat), advanced glycation end product inhibitors (benfotiamine, aspirin, aminoguanidine), the hexosamine pathway inhibitor (benfotiamine), inhibitor of poly ADP-ribose polymerase (nicotinamide), and angiotensin-converting enzyme inhibitor (trandolapril). The development of modern drugs to treat DN is a real challenge and needs intensive long-term comparative trials.

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Section: Treatment Of Dnmentioning

confidence: 99%

Section: Treatment Of Dnmentioning

confidence: 99%

Section: Treatment Of Dnmentioning

confidence: 99%

Section: Treatment Of Dnmentioning

confidence: 99%

“…Isosorbide dinitrate nasal spray and glyceryl trinitrate transdermal patches have shown positive effects in painful DN [105]. …”

Section: Treatment Of Dnmentioning

confidence: 99%

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Diabetic Neuropathy and Oxidative Stress: Therapeutic Perspectives

Hosseini

Abdollahi

2013

Oxidative Medicine and Cellular Longevity

179

124

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Complete Cycle Mapping Using a Quantitative At-Home Hormone Monitoring System in Prediction of Fertile Days, Confirmation of Ovulation, and Screening for Ovulation Issues Preventing Conception

Wegrzynowicz

BECKLEY²,

Eyvazzadeh³

et al. 2022

Medicina

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Background and Objectives: To achieve pregnancy, it is highly beneficial to identify the time of ovulation as well as the greater period of fertile days during which sperm may survive leading up to ovulation. Confirming successful ovulation is also critical to accurately diagnose ovulatory disorders. Ovulation predictor kits, fertility monitors, and tracking apps are all available to assist with detecting ovulation, but often fall short. They may not detect the full fertile window, provide accurate or real-time information, or are simply expensive and impractical. Finally, few over-the-counter products provide information to women about their ovarian reserve and future fertility. Therefore, there is a need for an easy, over-the-counter, at-home quantitative hormone monitoring system that assesses ovarian reserve, predicts the entire fertile window, and can screen for ovulatory disorders. Materials and Methods: Proov Complete is a four-in-one at-home multihormone testing system that utilizes lateral flow assay test strips paired with the free Proov Insight App to guide testing of four hormones—FSH, E1G, LH, and PdG—across the woman’s cycle. In a pilot study, 40 women (including 16 with a fertility-related diagnosis or using fertility treatments) used Complete for one cycle. Results: Here, we demonstrate that Proov Complete can accurately and sensitively predict ovarian reserve, detect up to 6 fertile days and confirm if ovulation was successful, in one easy-to-use kit. Ovulation was confirmed in 38 cycles with a detectable PdG rise. An average of 5.3 fertile days (from E1G rise to PdG rise) were detected, with an average of 2.7 days prior to LH surge. Ovulation was confirmed via PdG rise an average of 2.6 days following the LH surge. While 38/40 women had a PdG rise, only 22 had a sustained PdG level above 5 ug/mL throughout the critical implantation window, indicating ovulatory dysfunction in 16 women. Conclusion: Proov Complete can detect the entire fertile window of up to 6 fertile days and confirm ovulation, while also providing information on ovarian reserve and guidance to clinicians and patients.

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Study of management on comorbid conditions in type-2 diabetes mellitus

S¹,

Rao²,

Priyanka³

2018

cell-science

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Main aim of this study is to treat co-morbid conditions which are associated with type-2 DM.Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia; is associated with abnormalities in carbohydrates, fat, and protein metabolism; and results in chronic complications including microvascular, macrovascular, and neuropathic disorders. The long term complications include retinopathy with potential blindness, nephropathy with kidney failure and neuropathy with risk of foot ulcers, amputation, and Charcot joint and sexual dysfunction. Macrovascular event is responsible for 75% of deaths in patients having type-2 DM. Multiple risk factors are responsible for developing type-2 DM, which include family history, obesity, habitual physical activity, race or ethnicity, previously identified impaired glucose tolerance or impaired fasting glucose, hypertension, high density lipoprotein cholesterol and triglyceride. This study is done to manage the comorbid conditions of diabetes mellitus. This study is a prospective observational study which was conducted over a period of 6 months among type-2 diabetic patients attending at an out-patient department of Care Diabetes Center, Hanamakonda, Warangal, Andhra Pradesh. This study took place between March and September 2013. Collected all relevant information from the patient's case sheets, laboratory reports, patients care taker, treatment charts and counseling. All the collected information documented properly by data collection form. Out of 554 patients was enrolled into the study. Among them 252 (45.48%) of these patients were men and 302 (54.52%) were females respectively. 58.48% (324) were associated with macrovascular complications and 33.39% (185) were associated with microvascular complications. This study was conducted to increase prevalence of disease, through creating awareness about drug treatment and diabetic complications. Among the various complications, macrovascular complications caused major threat and among macrovascular complications, Hyperlipidemia and hypertension are major causes. Prophylaxis was done for patient's inorder to prevent the further complication of diabetes mellitus.

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Diabetic Neuropathic Pain: Real World Treatment Options

Cited by 4 publications

References 110 publications

Diabetic Neuropathy and Oxidative Stress: Therapeutic Perspectives

Diabetic Neuropathy and Oxidative Stress: Therapeutic Perspectives

Complete Cycle Mapping Using a Quantitative At-Home Hormone Monitoring System in Prediction of Fertile Days, Confirmation of Ovulation, and Screening for Ovulation Issues Preventing Conception

Study of management on comorbid conditions in type-2 diabetes mellitus

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