Diabetic nephropathy without hyperglycemia

Macrae, Jeanne; Nicastri, Anthony D.; Chen, C.K.

doi:10.1016/0891-6632(90)90053-8

Cited by 12 publications

(2 citation statements)

References 45 publications

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“…Due to this definition, since then, the majority of authors have dismissed ING cases with some kind of IGM not proper DM. In the same way, cases that have been diagnosed as diabetic retinopathy but did not meet DM analytic criteria are referred in the majority as DN [ 36 , 37 ] even though they would not develop DM until as late as nine years after. This fact was left aside from this analysis cases described as diabetic nephropathy very similar to those referred as ING with impaired fasting glucose at diagnosis according to the current criteria.…”

Section: Associated Factors and Possible Pathogenic Mechanismsmentioning

confidence: 99%

Diabetic Nephropathy without Diabetes

López-Revuelta

Abreu

Gerrero-Márquez

et al. 2015

JCM

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Diabetic nephropathy without diabetes (DNND), previously known as idiopathic nodular glomerulosclerosis, is an uncommon entity and thus rarely suspected; diagnosis is histological once diabetes is discarded. In this study we describe two new cases of DNND and review the literature. We analyzed all the individualized data of previous publications except one series of attached data. DNND appears to be favored by recognized cardiovascular risk factors. However, in contrast with diabetes, apparently no factor alone has been demonstrated to be sufficient to develop DNND. Other factors not considered as genetic and environmental factors could play a role or interact. The most plausible hypothesis for the occurrence of DNND would be a special form of atherosclerotic or metabolic glomerulopathy than can occur with or without diabetes. The clinical spectrum of cardiovascular risk factors and histological findings support this theory, with hypertension as one of the characteristic clinical features.

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Section: Associated Factors and Possible Pathogenic Mechanismsmentioning

confidence: 99%

Diabetic Nephropathy without Diabetes

López-Revuelta

Abreu

Gerrero-Márquez

et al. 2015

JCM

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“…Since the patient was not under medical care before becoming hypertensive, it is impossible to rule out the presence of abnormal glucose tolerance during that period. Macrae et al [8] have recently reported on 3 patients and reviewed on other 23 previously published cases of diabetic nephropathy without hyper glycemia. Among the 26 patients, they distinguished 5 whose 2-hour blood glucose on oral GTT was under 140 mg/dl (7.8 mmol/1) and whom they considered to be true examples of diabetic nephropathy in the absence of hyperglycemia.…”

Section: Discussionmentioning

confidence: 99%

Nodular Diabetic Glomerulosclerosis without Diabetes mellitus

Silva¹,

Saldanha²,

Pestalozzi³

et al. 1992

Nephron

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A 66-year-old white man presented with severe chronic renal failure. He had no past or present symptomatic glucose intolerance nor a family history of diabetes mellitus. Several fasting plasma glucose determinations, hemoglobin Ale and an oral glucose tolerance test were normal. Funduscopic ophthalmoscopy and retinal fluorescein angiography did not demonstrate diabetic retinopathy. The kidney biopsy showed nodular diabetic nephropathy, with increased mesangial matrix, thickened glomerular basement membrane, and afferent and efferent glomerular arteriolar hyalinization. The diagnosis of nodular diabetic nephropathy was made in this patient in the absence of past or present or familial evidence of diabetes mellitus.

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A case of idiopathic nodular glomerulosclerosis with fibrin caps

Kinoshita¹,

Inoue²,

Kanda³

et al. 2011

Clin Exp Nephrol

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We report a case of idiopathic nodular glomerulosclerosis (ING) mimicking diabetic Kimmelstiel-Wilson glomerulopathy. A 72-year-old man suffering from nephritic syndrome and renal dysfunction had no prior history of diabetes mellitus, but had impaired glucose tolerance and a history of hypertension and smoking. A kidney biopsy showed increased mesangial matrix with Kimmelstiel-Wilson-like nodules, glomerular basement membrane thickening and capillary microaneurysms. Additionally, a large amount of fibrin caps detectable as electron-dense subendothelial material by electron microscopy were observed. Although ING with fibrin caps has been rarely reported, the large number of fibrin caps seen in this case may be due to the advanced clinical stage.

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Diabetic nephropathy without hyperglycemia

Cited by 12 publications

References 45 publications

Diabetic Nephropathy without Diabetes

Diabetic Nephropathy without Diabetes

Nodular Diabetic Glomerulosclerosis without Diabetes mellitus

A case of idiopathic nodular glomerulosclerosis with fibrin caps

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