Diabetic nephropathy is an independent factor associated to severe subclinical atheromatous disease

Barrios, Clara; Pascual, Julio; Otero, Sol; Soler, María José; Rodríguez, Eva; Collado, Sílvia; Faura, Anna; Mojal, Sergi; Navarro‐González, Juan F.; Betriu, Àngels; Fernàndez, Elvira; Valdivielso, José M.

doi:10.1016/j.atherosclerosis.2015.06.048

Cited by 26 publications

(20 citation statements)

References 30 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CVD has remained the leading cause of death in patients with T1DM and T2DM [14]. Studies indicate that DN patients are more likely to suffer from severe CVD with higher morbidity and mortality versus those without DN [15][16][17][18]38]. In the Go-DARTS and MESA studies, LVH was identified as adverse cardiac remodeling in patients with T2DM and renal insufficiency [39,40].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, several recent studies have confirmed the connection between diabetic microvascular disease and macrovascular disease. The link is most obvious for patients with DN, which has been identified as a major predictor of cardiovascular morbidity and mortality [15][16][17][18]. Left ventricular hypertrophy (LVH), a major manifestation of diabetic cardiomyopathy [19], has been identified as an independent risk factor for myocardial infarction, heart failure, arrhythmia, and other causes of cardiovascular deaths [20,21].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Poor Renal and Cardiovascular Outcomes in Patients with Biopsy-Proven Diabetic Nephropathy

Wang¹,

Zhou²,

Zhang³

et al. 2020

Kidney Blood Press Res

View full text Add to dashboard Cite

Background: Despite the high mortality of cardiovascular disease (CVD) in diabetic patients with renal injury, few studies have compared cardiovascular characteristics and outcomes between patients with diabetic nephropathy (DN) and non-diabetic renal disease (NDRD). Methods: A total of 326 type 2 diabetes mellitus patients with renal biopsy were assigned to DN and NDRD groups. Echocardiography and Doppler ultrasound were performed to evaluate left ventricular hypertrophy (LVH) and peripheral atherosclerosis disease (PAD). Renal and cardiovascular survival rates were compared between the DN and NDRD groups by Kaplan-Meier analysis. Risk factors for renal and cardiovascular events in DN patients were identified by a Cox proportional hazards model. Results: In total, 179 patients entered the DN group (54.9%) and 147 made up the NDRD group (45.1%). The presence of diabetic retinopathy, family history of diabetes, and dependence on insulin therapy were associated with the presence of DN. DN patients had more CVD with more severe LVH and PAD. Poorer renal (log-rank χ 2 = 26.534, p < 0.001) and cardiovascular (log-rank χ 2 = 16.257, p < 0.001) prognoses were seen in the DN group. DR (HR 1.539, 95% CI 1.332-1.842), eGFR (HR 0.943, 95% CI 0.919-0.961), and 24-h proteinuria (HR 1.211, 95% CI 1.132-1.387) were identified as risk factors for renal endpoints. Age (HR 1.672, 95% CI 1.487-1.821), HbA1C (HR 1.398, 95% CI 1.197-1.876), and 24-h proteinuria (HR 1.453, 95% CI 1.289-1.672) were associated with cardiovascular endpoints. Conclusion: Patients with DN had more severe CVD along with poorer renal and cardiovascular prognoses than those with NDRD.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Poor Renal and Cardiovascular Outcomes in Patients with Biopsy-Proven Diabetic Nephropathy

Wang¹,

Zhou²,

Zhang³

et al. 2020

Kidney Blood Press Res

View full text Add to dashboard Cite

show abstract

“…For instance, there is evidence that smoking increases the CV risk of patients on dialysis [36,37]. The increased CV risk profile of diabetics all along the spectrum of CKD is also well-known, and was clearly detected in the baseline analysis of the NEFRONA study [38]. Finally, hyperphosphatemia has been clearly linked to the CV outcome of patients on dialysis [39,40].…”

Section: Discussionmentioning

confidence: 92%

The Modality of Dialysis Does Not Influence Atheromatous Vascular Disease Progression or Cardiovascular Outcomes in Dialysis Patients Without Previous Cardiovascular Disease

Sans¹,

Pérez‐Fontán²,

Martínez-Alonso³

et al. 2018

Journal of Vascular Surgery

View full text Add to dashboard Cite

show abstract

“…Increased albuminuria has been accepted to be a principle risk factor of cardiovascular and renal diseases in T2DM (28). Barrios et al (29) found that, patient with any stages of DN had higher risk of atherosclerosis compared to nondiabetic chronic kidney disease. Momeni et al (30) showed that proteinuria was associated with atherosclerosis in T2DM.…”

Section: Discussionmentioning

confidence: 99%

The Evaluation of SCUBE-1 and sCD40L Levels in Diabetic Nephropathy

Karakaş

Eren

Koyuncu

et al. 2019

Düzce Tıp Fakültesi Dergisi

View full text Add to dashboard Cite

Aim: There is a close link between diabetic nephropathy and atherosclerotic heart disease. We aimed to evaluate the changes of SCUBE-1 and sCD40L, which play role in the course of atherosclerosis, with the progression of nephropathy in patients with type 2 diabetes. Material and Methods: Thirty healthy subjects (group 1) and 74 patients with type 2 diabetes (divided into 3 groups as normal albuminuria group (group 2, n=33), moderately increased albuminuria group (group 3, n=22) and severely increased albuminuria group (group 4, n=19)) were enrolled in the study. Plasma SCUBE-1 and sCD40L levels were measured using the enzyme-linked immunosorbent assay technique. Results: Mean SCUBE-1 levels were significantly higher in group 4 compared to group 1 and group 2 (p=0.005 and p=0.014, respectively) and in group 3 compared to group 1 and group 2 (p=0.011 and p=0.028, respectively). Mean sCD40L levels were significantly higher in group 4 than in other three groups (all p<0.001), and in group 3 than in group 1 and group 2 (p=0.001 and p=0.016, respectively). Furthermore, SCUBE-1 level was positively correlated with total cholesterol level (r=0.212, p=0.031) and triglyceride (r=0.194, p=0.049). Likewise, sCD40L level was positively correlated with only creatinine level (r=0.297, p=0.002). Conclusion: SCUBE-1 and sCD40L levels increased with the progression of nephropathy in type 2 diabetes. This increment suggested that SCUBE-1 and sCD40L may play key role in the course of atherosclerosis due to diabetic nephropathy and, diabetic nephropathy may affect the levels of these parameters.

show abstract

Diabetic nephropathy is an independent factor associated to severe subclinical atheromatous disease

Cited by 26 publications

References 30 publications

Poor Renal and Cardiovascular Outcomes in Patients with Biopsy-Proven Diabetic Nephropathy

Poor Renal and Cardiovascular Outcomes in Patients with Biopsy-Proven Diabetic Nephropathy

The Modality of Dialysis Does Not Influence Atheromatous Vascular Disease Progression or Cardiovascular Outcomes in Dialysis Patients Without Previous Cardiovascular Disease

The Evaluation of SCUBE-1 and sCD40L Levels in Diabetic Nephropathy

Contact Info

Product

Resources

About