Diabetic Nephropathy an Obvious Complication in Long Term Type 1 Diabetes Mellitus: A Case Study

Abstract

Most overwhelming complications of Type 1 diabetes mellitus patients are responsible for complications related to the microvascular system most likely with kidney. In the kidney, hyperglycemia induced microangiopathy resulting not only thickening of the glomerular capillary basement membrane but also to the proliferation of the mesangial matrix and solidifying of the tubular basement membrane. Several biochemical and pathological, factors are concerned for the development of diabetic renal microangiopathy. These include the glomerular hyperperfusion and hyperfiltration, transformed morphology of podocytes accompanies these basement membrane modifications, Type IV collagen augmented synthesis following the hyperglycemia, and increased expression of tissue matrix metalloproteinase. The aim of this case review is to highlight the recent advances in understanding the pathogenesis, diagnosis, the overview and the potential renoprotective therapeutic agents that would prevent the development or the progression of diabetic nephropathy.

Hereditary mucinous ovarian cancer complicated with omental metastasis: A case report

“…They may remain entirely asymptomatic and occasionally are found unexpectedly on abdominal or pelvic examination or during surgery. Irrespective of the types, mainstream of the malignant tumorshas usually spread outside the ovary by the time a conclusive diagnosis is made [5][6][7] . The mostcommon primary sites for mucinous carcinomas metastatic tothe ovary are gastrointestinal, pancreas, cervix, breast, and uterus 8 .…”

THE PRO-INFLAMMATORY ROLE OF MICRORNA-29b IN DIABETIC NEPHROPATHY

“…Diabetic nephropathy (DN) is the most common and prevalent macrovascular complication of both Type 1 diabetes mellitus (T1DM) and Type 2 diabetes mellitus (T2DM) [1,2], which is characterized by the presence of trace albuminuria followed by a diminished glomerular filtration rate [3] The mechanism involved in the pathogenesis of DN still unclear. There is growing evidence support that is DN mainly a chronic inflammatory process, and increasing numbers of inflammatory mediators have been shown to play key roles in its development [4].…”