Diabetic Nephropathy

Da, Goldstein; Sg, Massry

doi:10.1159/000181239

Cited by 62 publications

(11 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to Gellman et al [7], ne phrotic syndrome exists in 13 (26%) out of 53 patients with diabetic nephropathy. A long-term follow-up study of diabetic patients reveals that the mean duration of dia betes at the onset of proteinuria is 17.3 6.0 years and end-stage renal disease develops within 3.0¿0.2 years after the onset of renal abnormalities [2,8]. On the other hand membranous glomerulonephritis is a major cause of the nephrotic syndrome [9] and is characterized by slow progression and/or spontaneous remission and relapse.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Membranous Glomerulonephritis Associated with Diabetes mellitus

Kobayashi¹,

Harada²,

Onoyama³

et al. 1981

Nephron

View full text Add to dashboard Cite

The present study described 3 patients with idiopathic membranous glomerulonephritis associated with diabetes mellitus. Clinical characteristics of the 3 patients contrasted with diabetic glomerulosclerosis in the following manner: absence of diabetic retinopathy and neuropathy, and presence of nephrotic syndrome associated with relatively short duration of diabetes mellitus. Renal histology showed the characteristic changes of membranous glomerulonephritis along with those of diabetic glomerulosclerosis. Immunofluorescent studies demonstrated a granular pattern of IgG and C₃ deposits along the glomerular capillary wall. Electron microscopic study also demonstrated thickening of glomerular basement membrane and increase of mesangial matrix as well as the presence of electron-dense deposits primarily in the subepithelial and mesangial areas.

show abstract

Section: Discussionmentioning

confidence: 99%

Idiopathic Membranous Glomerulonephritis Associated with Diabetes mellitus

Kobayashi¹,

Harada²,

Onoyama³

et al. 1981

Nephron

View full text Add to dashboard Cite

show abstract

“…Dia betic nephropathy, once clinically manifest, is a progressive chronic renal disease. A long-term follow-up of 150 pa tients with diabetic nephropathy showed that endstage renal disease may develop within 3.0 0.2 years after the onset of renal abnormalities (proteinuria and/or decrease in renal function) [11], On the other hand, some forms of 1CGN may resolve completely. A careful distinction be tween these 2 entities is of clinical and prognostic import ance.…”

Section: Discussionmentioning

confidence: 99%

Diabetes Mellitus with Immune Complex Glomerulonephritis

Aziz

Cohen

Winer

et al. 1979

Nephron

Self Cite

View full text Add to dashboard Cite

The present study describes 3 patients with the simultaneous occurrence of diabetic nephropathy and immune-complex mediated glomerulonephritis. Renal manifestation included proteinuria and hematuria which were preceded by or co-existent with an infectious process. Renal histology showed the characteristic change of diabetic nephropathy along with those of immune complex glomerulonephritis. Immunofluorescence studies showed a linear pattern with a superimposed granular pattern of IgG and C₃ deposits. Renal function and urinary findings improved in the 2 patients who were followed up.

show abstract

“…Over a 2-year period in one study, average urine protein excretion increased from 1.8 to 3.3 g/day [86, 87]. The amount of total proteinuria in diabetic nephropathy patients is typically subnephrotic (<3.5 g/24 h) or nephrotic, with as many as 70–80% being nephrotic in some earlier studies of type 1 and type 2 patients with nephropathy [88]. Hypertension is an early feature in the course of persistent proteinuria, even when renal function is normal or only slightly impaired [89, 90].…”

Section: Natural Historymentioning

confidence: 99%

Diabetic Nephropathy: The Proteinuria Hypothesis

Williams¹

2005

Am J Nephrol

View full text Add to dashboard Cite

Background/Aims: Proteinuria, nearly a universal finding in progressive kidney disease, has been the subject of frequent recent analyses in the renal literature. Proteinuria is a hallmark of diabetic nephropathy: microalbuminuria is the principal early predictor for progression of diabetic glomerulopathy, and proteinuria may be viewed as a measure of the severity and promoter of progression of nephropathy. Methods: This article critically reviews for the first time the full scope of diabetic proteinuria – complex molecular mechanisms, natural history, and analysis of treatment trials – in order to address the validity of ‘the proteinuria hypothesis’, i.e., that diabetic proteinuria is a modifiable determinant of renal progression. This hypothesis is analyzed in detail, including recent studies on the primary therapy of diabetic nephropathy, renin-angiotensin blockade. Results: As fully developed, this hypothesis consists of three postulates: that higher amounts of proteinuria predict progressive loss of function, that proteinuria reduction correlates with slowing progression, and that proteinuria is a surrogate endpoint for clinical trials. The latter postulate has not before been adequately linked to growing information about the first two postulates as they apply to diabetic kidney disease. Conclusion: While diabetic nephropathy is a disease model for the potential use of proteinuria as a surrogate marker for renal progression, this shift in perspective will require prospective data from additional clinical trials, particularly of non-renin-angiotensin blocking drugs, to be complete.

show abstract

Diabetic Nephropathy

Cited by 62 publications

References 22 publications

Idiopathic Membranous Glomerulonephritis Associated with Diabetes mellitus

Idiopathic Membranous Glomerulonephritis Associated with Diabetes mellitus

Diabetes Mellitus with Immune Complex Glomerulonephritis

Diabetic Nephropathy: The Proteinuria Hypothesis

Contact Info

Product

Resources

About