Diabetic microvascular complications are associated with left atrial structural alterations in asymptomatic type 2 diabetes patients: A cross-sectional study

Gong, Ming; Xu, Min; Meng, Jian; Jiang, Shu; Jiang, Xiaohong

doi:10.1016/j.jdiacomp.2022.108361

Cited by 2 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4D auto LAQ is a LA analysis technique that uses 3D volume data to determine the LA volume of different periods in diastole as well as LA longitudinal and circumferential strains. It was reported that it had the advantages of high sensitivity, reproducibility and accuracy [10], and it was applied to multiple clinical diseases, such as patients with arrhythmia, the high risk of thromboembolism, type 2 diabetes, heart failure and so on [11][12][13][14]. There are no studies published about LA function assessed by 4D auto LAQ for distinguishing pre-from post-capillary PH.…”

Section: Introductionmentioning

confidence: 99%

The additive value of left atrial function measured by 4D auto left atrial quantification echocardiography for distinguishing between pre-capillary and post-capillary pulmonary hypertension

Lei

Xiao

et al. 2023

Preprint

View full text Add to dashboard Cite

Objective The purpose of this study was to investigate the value of left atrial (LA) volume and strain by 4D auto left atrial quantification (LAQ) for differentiating pre- and post-capillary pulmonary hypertension (PH), and compare the discriminative ability with echocardiographic pulmonary to left atrial global strain ratio (ePLAGS). Methods A total of ninety-eight subjects screened for intermediate to high probability of PH were prospectively enrolled in this study. Clinical history and laboratory data of all the patients were collected. All the patients underwent comprehensive transthoracic echocardiography and then LA volume and strain were measured by dedicated commercial software specially designed for LA 4D analysis. Results According to pulmonary arterial wedge pressure, the participants were divided into two groups: pre-capillary PH Group (n=39, age 53±24 year) and post-capillary PH Group (n=59, age 57 ± 18 year). LAVImax, LAVImin and LAVIpreA significantly increased, while LASr and LAScd obviously decreased in post-capillary PH group when comparing with pre-capillary PH group. Multivariate logistic regression analysis showed LAVImax (OR: 1.40; 95% CI, 1.05–1.87; P = 0.021) and LAScd (OR: 1.76; 95% CI, 1.18–2.49; P = 0.004) were powerful independent predictors for detecting post-capillary PH. The ROC analysis indicated that LAVImax (AUC=0.82, p < 0.001) and LAScd (AUC=0.78, p <0.001) had high discriminating power for predicting post-capillary PH groups, and their cutoff values were 35.69ml/m2 (sensitivity 86%, specificity 74%) and -9% (sensitivity 80%, specificity70%). Conclusions LAVImax and LAScd measured by 4D auto LAQ were powerful parameters for distinguishing pre-capillary PH from post-capillary PH.

show abstract

Section: Introductionmentioning

confidence: 99%

The additive value of left atrial function measured by 4D auto left atrial quantification echocardiography for distinguishing between pre-capillary and post-capillary pulmonary hypertension

Lei

Xiao

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Evaluation of the relationship between left atrial stiffness, left ventricular stiffness, and left atrioventricular coupling index in type 2 diabetes patients: a speckle tracking echocardiography study

Dang,

Luong,

2024

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

BackgroundCardiovascular complications are a leading cause of mortality and disability in individuals with diabetes mellitus (DM). Moreover, DM can directly impact the structure and function of cardiac muscle. We conducted a study to evaluate cardiac stiffness in DM patients in both the left atrium (LA) and left ventricle (LV), as well as to assess the impact of DM on the synchronization of the LA and LV, particularly within the Vietnamese population, utilizing speckle tracking echocardiography (STE).MethodsWe studied 111 research subjects divided into two groups comprising 52 patients with DM and 59 healthy individuals. All the subjects provided relevant clinical information, and echocardiography was performed to assess the indices of LA stiffness, LV stiffness, and left atrioventricular coupling index (LACI).ResultsOur study indicated that DM patients exhibited greater LA and LV stiffness than control patients. The LACI (%) in the DM group was also greater than that in the control group (17.12% ± 6.72% vs. 12.28% ± 3.96%, respectively; p < 0.001). The LACI was positively correlated with the LA and LV stiffness indices. Decreased levels of LV GLS, adjusted for age, sex, blood pressure, and BMI, have emerged as identified risk factors for DM.ConclusionsLA stiffness, LV stiffness, and the LACI are greater in DM patients than in normal individuals.

show abstract

Diabetic microvascular complications are associated with left atrial structural alterations in asymptomatic type 2 diabetes patients: A cross-sectional study

Cited by 2 publications

References 26 publications

The additive value of left atrial function measured by 4D auto left atrial quantification echocardiography for distinguishing between pre-capillary and post-capillary pulmonary hypertension

The additive value of left atrial function measured by 4D auto left atrial quantification echocardiography for distinguishing between pre-capillary and post-capillary pulmonary hypertension

Evaluation of the relationship between left atrial stiffness, left ventricular stiffness, and left atrioventricular coupling index in type 2 diabetes patients: a speckle tracking echocardiography study

Contact Info

Product

Resources

About