Diabetic Mastopathy of Bilateral Breasts in an Elderly Japanese Woman with Type 2 Diabetes: A Case Report and a Review of the Literature in Japan

Honda, Munehiro; Mori, Yusaku; Nishi, Tsunehiro; Mizuguchi, Kunio; Ishibashi, Masayoshi

doi:10.2169/internalmedicine.46.6191

Cited by 15 publications

(6 citation statements)

References 23 publications

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“…In most series, the patients are relatively young (premenopausal age), and have an early onset of long-standing type 1 diabetes, generally with severe diabetic complications. Occasionally, the condition has also been observed in patients with type 2 diabetes [10,11] or those with autoimmune disorders such as Hashimoto's thyroiditis, arthropathy, and lupus erythematosus [1,6]. Epithelioid fibroblasts, believed to be specific for diabetic condition, were seen in our case without a diabetic history and other clinical data.…”

Section: Discussionsupporting

confidence: 48%

“…Thus, epithelioid fibroblasts appear to be not as specific as previously maintained in the diabetic mastopathy. Although many possible mechanisms have been suggested for the cause of lymphocytic mastopathy, none has been proven [5,11]. While some of the discussed reasons may explain the findings in a setting of hyperglycemia and exogenous insulin use, an autoimmune basis would best address their presence among nondiabetic patients.…”

Section: Discussionmentioning

confidence: 99%

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A case of lymphocytic mastopathy requiring differential diagnosis from primary breast lymphoma

et al. 2008

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Lymphocytic mastopathy is a benign breast disease characterized by dense fibrosis, lobular atrophy, and aggregates of lymphocytes in a periductal and perivascular distribution. The condition affects young to middle-aged women and frequently shows an association with diabetes mellitus or autoimmune disorders. Here, we report a case of the disease clinically and radiologically mimicking primary breast neoplasms. The patient was a 50-year-old woman without diabetes who presented with two firm lumps in her right breast. Breast imaging findings from mammography, ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI), respectively, revealed an abnormal appearance suspicious of malignancy. A core-needle biopsy specimen showed atypical accumulation of lymphoid cells, which was not easy to differentiate from primary breast lymphomas. Moreover, (18)fluorodeoxyglucose positron emission tomography (FDG-PET) examination detected abnormal uptake in the same lesions. Histological examination of a surgically obtained specimen showed characteristic appearance of lymphocytic mastopathy, which predominantly consisted of B-lymphocytes. In our case, it was difficult to distinguish this entity from breast cancer or low-grade B-cell lymphoma without surgical biopsy.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

A case of lymphocytic mastopathy requiring differential diagnosis from primary breast lymphoma

et al. 2008

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“…This is fitting with our patient who had a 23-year history of reasonably well-controlled diabetes complicated by minimal retinopathy. To a much lesser extent, diabetic mastopathy has been reported in men [4] and in patients with Type II diabetes who are often insulin dependent [5, 6]. Clinical features include unilateral or bilateral, single or multiple, nontender, palpable breast masses that are firm to hard in consistency, mimicking malignancy, and mandating further evaluations.…”

Section: Discussionmentioning

confidence: 99%

Diabetic Mastopathy as a Radiographically Occult Palpable Breast Mass

Thanarajasingam

Chen

Tortorelli

et al. 2011

Case Reports in Medicine

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Diabetic mastopathy is an uncommon, benign disease of the breast that can occur in women with diabetes and clinically mimic breast cancer. We describe a patient with long-standing type 1 diabetes who presented with a palpable breast mass with negative imaging findings on mammography, ultrasonography, and breast MRI. Surgical biopsy and histopathology confirmed diabetic mastopathy. We use this case to highlight the recognition, radiographic features, pathology, and management of this benign breast condition and emphasize that, in diabetic patients, the differential diagnosis of a new breast mass should include diabetic mastopathy.

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“…This condition is also found in patients with other endocrine disorders, especially thyroid diseases 2,6,8) . Honda et al 10) reported differences of diabetic mastopathy between Japan and Western countries, showing that most cases in Western countries are in premenopausal women with type I diabetes, while in Japan, most cases are in postmenopausal women with type II diabetes. They speculated that differences of genetic factors, including HLA type, between Japan and the Western countries were the source of this finding.…”

Section: Case Reportmentioning

confidence: 99%

Diabetic Mastopathy in an Elderly Woman: A Case Report

Tsuchiya

Tsunoda²,

Seino³

et al. 2010

FJMS

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: We report a case of diabetic mastopathy in an elderly woman with type II diabetes. The patient, a 66 -year -old woman with a 6 -year history of diabetes mellitus, has been received an oral diabetic agent. She noticed a lump in her right breast two months previously. Mammography of the breast showed a low density mass, but there was no microcalcification or architectural distortion. Ultrasonography of the lesion revealed a hypoechoic mass with a distinct margin. Fine needle aspiration cytology was performed but sufficient tissue was not obtained. However, a cluster of small epithelial cells with nucleus swelling and increased chromatin was demonstrated. Excisional biopsy was performed and diabetic mastopathy was demonstrated histologically.

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Diabetic Mastopathy of Bilateral Breasts in an Elderly Japanese Woman with Type 2 Diabetes: A Case Report and a Review of the Literature in Japan

Abstract: We

Cited by 15 publications

References 23 publications

A case of lymphocytic mastopathy requiring differential diagnosis from primary breast lymphoma

A case of lymphocytic mastopathy requiring differential diagnosis from primary breast lymphoma

Diabetic Mastopathy as a Radiographically Occult Palpable Breast Mass

Diabetic Mastopathy in an Elderly Woman: A Case Report

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