Diabetic ketoacidosis in children: an 11-year retrospective in Surabaya, Indonesia

Rochmah, Nur; Faizi, Muhammad; Harjantien, Netty

doi:10.14238/pi55.1.2015.40-3

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…The incidence of recurrent DKA is different across the world due to the quality of health care services and socioeconomic circumstances. The incidence of DKA in established diabetes children in the US was 8 per 100 person-years [3], in Sweden 3.2-3.6/100 patient-years [4] in French o.7% [5], in Indonesia 41.4% [6], in Germany and Austria 6% [7] and in Italy 38.5% [8]. Were as in Africa the data on the incidence of DKA in established diabetes is scarce, but some studies report a high frequency of DKA in Sudan 92.1% [9], north-western Nigeria 62.2% [10], in South Africa 69.8% [11].…”

Section: Introductionmentioning

confidence: 98%

Incidence and predictors of diabetic ketoacidosis among children with diabetes in west and east gojjam zone referral hospitals north west Ethiopia, 2019.

assefa

Zeleke

Murugan

et al. 2020

Preprint

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Background: Recurrent diabetic ketoacidosis in patients with already diagnosed diabetic mellitus remains a relevant problem in pediatric with an incidence of 1–10% per patient. Children may die due to cerebral edema and had significant mortality (24%) and morbidity (35%).Objective: We assess the incidence and predictors of diabetic ketoacidosis among diabetic children at East and West Gojjam zone referral hospitals, North West Ethiopia, 2019.Methods: An institution-based retrospective follow up study was conducted on children who were registered from January 1, 2014, to January 1, 2019. Epi data version 3.1 & Stata 14 were used for data entering and analysis respectively.Result: A total of 354 children were included from this 207(58.5%) had diabetic ketoacidosis. The overall incidence rate of diabetic ketoacidosis was 2.27/100 children/month of observation. Age <5 years (AHR: 3.52, 95% CI (2.25, 5.49), non-adherence (AHR: 1.54, 95% CI (1.11, 2.14), inappropriate insulin storage (AHR: 1.36, 95% CI (1.008, 1.85), presence of upper respiratory tract infections during diabetic ketoacidosis diagnose (AHR: 2.22, 95% CI (1.11, 4.45) and preceding gastroenteritis (AHR: 2.18, 95% CI (1.07, 4.44) were significant predictors. Conclusion: age <5 years old, non-adherence, inappropriate insulin placement at home, Preceding gastroenteritis, and presence of upper respiratory tract infections at the time of diabetic ketoacidosis development were significant predictors. Hence, assessing and close monitoring as well as strengthened diabetic education should be given for the above predictors.

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Section: Introductionmentioning

confidence: 98%

Incidence and predictors of diabetic ketoacidosis among children with diabetes in west and east gojjam zone referral hospitals north west Ethiopia, 2019.

assefa

Zeleke

Murugan

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The incidence of recurrent DKA is varied across the world due to the difference in the quality of health care services and socioeconomic circumstances. The incidence of DKA in known diabetes children in the US was 8 per 100 person-years [3], in Sweden 3.2-3.6/100 patient-years [4], in French 0.7% [5], in Indonesia 41.4% [6], in Germany and Austria 6% [7] and in Italy 38.5% [8]. Whereas in Africa the data on the incidence of DKA in known diabetes is scarce, but some studies report a high frequency of DKA in Sudan 92.1% [9], northwestern Nigeria 62.2% [10], in South Africa 69.8% [11].…”

Section: Introductionmentioning

confidence: 98%

Incidence and predictors of diabetic ketoacidosis among children with diabetes in West and East Gojjam zone referral hospitals Northern Ethiopia, 2019

assefa

Zeleke

Murugan

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Recurrent diabetic ketoacidosis in patients with known diabetes mellitus remains a relevant problem in pediatrics with an incidence of 1–10% per patient. Children may die because of cerebral edema and had a significant mortality (24%) and morbidity (35%). Objective: We assessed the incidence and predictors of diabetic ketoacidosis among diabetes children at East and West Gojjam zone referral hospitals, North West Ethiopia, 2019. Methods: An institution-based retrospective follow up study was conducted on children who were registered from January 1, 2014, to January 1, 2019. Epi data version 3.1 & Stata 14 were used for data entering and analysis respectively. Result: Out of 354 children included in the study, 207 (58.5%) developed diabetic ketoacidosis. The overall incidence rate of diabetic ketoacidosis was 2.27/100 children/month of observation. Age <5 years (AHR: 3.52, 95% CI (2.25, 5.49), non-adherence (AHR: 1.54, 95% CI (1.11, 2.14), inappropriate insulin storage (AHR: 1.36, 95% CI (1.008, 1.85), presence of upper respiratory tract infections during diabetic ketoacidosis diagnose (AHR: 2.22, 95% CI (1.11, 4.45) and preceding gastroenteritis (AHR: 2.18, 95% CI (1.07, 4.44) were significant predictors. Conclusion: Age < 5 years old, non-adherence, inappropriate insulin placement at home, preceding gastroenteritis, and presence of upper respiratory tract infections at the time of diabetic ketoacidosis development were significant predictors. Hence, assessing and close monitoring as well as strengthened diabetic education should be given for the above predictors.

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“…In Indonesia, data from the Indonesian Pediatrician Association found 1,249 incidents of T1DM in children, with its prevalence increasing from 3.88 per 100 million in 2000 to 28.19 per 100 million population in 2010 (3). Type 1 diabetes is frequently misdiagnosed, and children with type 1 diabetes experience a phase of ketoacidosis due to delayed diagnosis, which can be fatal (4).…”

Section: Introductionmentioning

confidence: 99%

Quality of Life, Medication Adherence, and Glycemic Control in Type 1 Diabetes Mellitus Children with Basal Bolus Regimen During COVID-19 in Limited Resources Setting

et al. 2023

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Background: Type 1 Diabetes Mellitus (T1DM) is a chronic disease that requires complicated therapies. The coronavirus disease 2019 (COVID-19) pandemic has caused lockdown restrictions, compromising access to medical care, including T1DM management. Poor medication adherence may affect the quality of life (QoL) and glycemic control. Objectives: This study analyzed the association among QoL, medication adherence, and glycemic control in T1DM patients during the COVID-19 pandemic. Methods: This study recruited T1DM patients aged 5 - 18 who regularly visited the pediatric endocrinology outpatient clinic. The PedsQL 3.2 and the diabetes management questionnaire (DMQ) were used to measure QoL and medication adherence. In addition, glycemic control was measured based on HbA1c levels. All data were analyzed using SPSS version 17, and correlations between variables were analyzed using Spearman or Pearson correlation tests. Results: Twenty-five children and adolescents with a mean age of 141.1 months (± 36.7) were included in this study. The mean HbA1c level was 10.7 mg/dL (± 2.4). Around 19 (76%) participants had already experienced diabetic ketoacidosis (DKA). There was no significant correlation between QoL and medication adherence or HbA1c level (P = 0.220, r = - 0.254; P = 0.753, and r = - 0.066, respectively). Conclusions: Our study’s QoL and medication adherence of T1DM children was relatively good even though the HbA1c was still high. However, numerous factors affect QoL and medication adherence in T1DM children other than HbA1c level.

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Diabetic ketoacidosis in children: an 11-year retrospective in Surabaya, Indonesia

Abstract: Background Diabetic ketoacidosis (DKA) is a complication of

Cited by 5 publications

References 15 publications

Incidence and predictors of diabetic ketoacidosis among children with diabetes in west and east gojjam zone referral hospitals north west Ethiopia, 2019.

Incidence and predictors of diabetic ketoacidosis among children with diabetes in west and east gojjam zone referral hospitals north west Ethiopia, 2019.

Incidence and predictors of diabetic ketoacidosis among children with diabetes in West and East Gojjam zone referral hospitals Northern Ethiopia, 2019

Quality of Life, Medication Adherence, and Glycemic Control in Type 1 Diabetes Mellitus Children with Basal Bolus Regimen During COVID-19 in Limited Resources Setting

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