Diabetic ketoacidosis as a presenting symptom of complicated pancreatic cancer

Lee, Kyung Ae; Park, Kyung Taek; Kim, Woong Ji; Park, Tae Sun; Baek, Hong Sun; Jin, Heung Yong

doi:10.3904/kjim.2014.29.1.116

Cited by 4 publications

(5 citation statements)

References 4 publications

(4 reference statements)

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“…DKA is a severe complication of diabetes mellitus characterized by severe hyperglycemia and metabolic acidosis caused by absolute or relative insulin deficiency. Pancreatic adenocarcinoma is not known to be a presentation, complication, or cause of DKA [ 7 ]. Multiple theories have been postulated in an effort to investigate whether diabetes is a cause or a result of pancreatic cancer or if they simply coexist without causality.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, there are inconclusive data on the connection between diabetes mellitus and pancreatic cancer. Pancreatic cancer is usually diagnosed in advanced stages and has a bleak prognosis, with a 5-year survival rate of less than 5% [ 7 ]. No screening test sensitive and specific enough is available for the detection of early pancreatic cancer in the general population.…”

Section: Discussionmentioning

confidence: 99%

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Diabetic Ketoacidosis as the Initial Presenting Symptom of Pancreatic Adenocarcinoma: A Discussion about Screening Utilizing ENDPAC Scoring Coupled with CT Scans and Endoscopic Ultrasound

Menakuru¹,

Prişcu²,

Dhillon³

et al. 2022

Case Rep Oncol

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Pancreatic adenocarcinoma is often discovered at an advanced stage due to a lack of early symptomology, resulting in this being the fourth leading cause of cancer-related death in the USA. The relationship between diabetes mellitus and pancreatic cancer has been known for many years; however, it is not well understood. Studies have suggested that long-standing type 2 diabetes mellitus can increase the risk of pancreatic cancer by 1.5–2.0-fold. However, patients with new-onset diabetes over 50 years of age have an 8-fold higher risk of pancreatic cancer. Evidence has shown that pancreatic cancer causes diabetes, with the majority being new onset. Diabetic ketoacidosis, which occurs in long-term hyperglycemia, as an initial presentation of pancreatic adenocarcinoma is rare, and only a few cases have been reported. It is postulated that pancreatic cancer prevents insulin-producing cells of the pancreas from responding to insulin resistance. The enriching new-onset diabetes for pancreatic cancer (ENDPAC) score may be utilized as a screening tool for pancreatic carcinomas as an early diagnosis may lead to cure by surgery instead of the grave prognosis associated with it. In this case report, we discuss a 52-year-old female presenting with symptoms of diabetic ketoacidosis who was then subsequently found to have stage-4 pancreatic adenocarcinoma. We concluded that if a patient presents with new-onset diabetes, abdominal imaging with CT scans and endoscopic ultrasound may be warranted to rule out pancreatic carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diabetic Ketoacidosis as the Initial Presenting Symptom of Pancreatic Adenocarcinoma: A Discussion about Screening Utilizing ENDPAC Scoring Coupled with CT Scans and Endoscopic Ultrasound

Menakuru¹,

Prişcu²,

Dhillon³

et al. 2022

Case Rep Oncol

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“…The first involved a 75‐year‐old woman with longstanding DM2 who presented with DKA; pancreatic adenocarcinoma was later diagnosed 3 . The second case was in a 36‐year‐old woman with a history of gestational diabetes; she presented with DKA associated with a pancreatic abscess that was later found to include pancreatic adenocarcinoma 4 …”

Section: Discussionmentioning

confidence: 99%

Pancreatic adenocarcinoma presenting as first‐onset diabetic ketoacidosis

Zhong

Cross

2015

Medical Journal of Australia

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“…Patients with pancreatic cancer might have abdominal pain, weight loss, jaundice, back pain, vomiting, indigestion, and pruritus 2 . Pancreatic adenocarcinoma presenting with diabetic ketoacidosis (DKA) is very rare and to the best of our knowledge, only three cases have previously been reported 3, 4, 5. However, pancreatic cystadenocarcinoma presenting with DKA is not known.…”

Section: Introductionmentioning

confidence: 99%

“… 2 Pancreatic adenocarcinoma presenting with diabetic ketoacidosis (DKA) is very rare and to the best of our knowledge, only three cases have previously been reported. 3 , 4 , 5 However, pancreatic cystadenocarcinoma presenting with DKA is not known. Here, we present a case of pancreatic cystadenocarcinoma whose presenting symptom was DKA.…”

Section: Introductionmentioning

confidence: 99%

Diabetic ketoacidosis as the presenting manifestation of pancreatic adenocarcinoma with cystic features

Kaya

Korkmaz

Vargöl

et al. 2017

Turkish Journal of Emergency Medicine

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The common presenting symptoms of pancreatic cancer are abdominal pain, weight loss, and jaundice. Pancreatic adenocarcinoma presenting with diabetic ketoacidosis is a very rare emergent clinical condition. However, pancreatic ductal cystadenocarcinoma presenting with diabetic ketoacidosis was not reported. We describe a 60-year-old man with pancreatic cystadenocarcinoma presenting with diabetic ketoacidosis as the initial manifestation. It must be kept in mind that in diabetic ketoacidosis cases, the precipitating factor may be pancreatic ductal cystadenocarcinoma.

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Diabetic ketoacidosis as a presenting symptom of complicated pancreatic cancer

Cited by 4 publications

References 4 publications

Diabetic Ketoacidosis as the Initial Presenting Symptom of Pancreatic Adenocarcinoma: A Discussion about Screening Utilizing ENDPAC Scoring Coupled with CT Scans and Endoscopic Ultrasound

Diabetic Ketoacidosis as the Initial Presenting Symptom of Pancreatic Adenocarcinoma: A Discussion about Screening Utilizing ENDPAC Scoring Coupled with CT Scans and Endoscopic Ultrasound

Pancreatic adenocarcinoma presenting as first‐onset diabetic ketoacidosis

Diabetic ketoacidosis as the presenting manifestation of pancreatic adenocarcinoma with cystic features

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