1999
DOI: 10.1001/archinte.159.8.877
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Diabetic Gustatory Sweating Successfully Treated With Topical Glycopyrrolate

Abstract: For moderate to severe symptoms of diabetic gustatory sweating, topical application of glycopyrrolate is safe, effective, well tolerated, and convenient.

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Cited by 31 publications
(18 citation statements)
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“…Topical anticholinergics can be an alternative to botulinum toxin and an attractive first-line treatment of facial sweating. [3][4][5]16 Anticholinergics have the ability to inactivate sweat glands by the action of acetylcholine and may be more attractive to patients than simply occluding sweat ducts with aluminium compounds that can cause itching, stinging and skin irritation. Oral anticholinergics such as glycopyrrolate and oxybutynin have been used, but sometimes dry mouth can result as a major problem, thereby leading to discontinuance.…”
Section: Discussionmentioning
confidence: 94%
“…Topical anticholinergics can be an alternative to botulinum toxin and an attractive first-line treatment of facial sweating. [3][4][5]16 Anticholinergics have the ability to inactivate sweat glands by the action of acetylcholine and may be more attractive to patients than simply occluding sweat ducts with aluminium compounds that can cause itching, stinging and skin irritation. Oral anticholinergics such as glycopyrrolate and oxybutynin have been used, but sometimes dry mouth can result as a major problem, thereby leading to discontinuance.…”
Section: Discussionmentioning
confidence: 94%
“…These later anastomose with sudomotor sympathetic fibres of the skin, thereby gaining control of sweat gland activity [32, 33]. Aside from Frey's syndrome , gustatory sweating is a rare complication in diabetic patients with autonomic neuropathy [34].…”
Section: Introductionmentioning
confidence: 99%
“…Severe gustatory sweating is usually treated with oral anti-cholinergics. Topical glycopyrrolate has also been found to be beneficial [11].…”
Section: Discussionmentioning
confidence: 99%