Diabetic Gastropathy in Patients with Autonomic Neuropathy

Hongo, Michio; Okuno, Yo

doi:10.1111/j.1464-5491.1993.tb00207.x

Cited by 16 publications

(10 citation statements)

References 5 publications

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“…The appearance of 3-O-methyl- d -glucose in serum provided a measure of gastric emptying of a liquid meal and was significantly delayed in all AIDS subgroups. Delayed gastric emptying may be the consequence of malnutrition,20 neuropathy,21 or systemic disease22 and may explain symptoms such as early satiety, nausea, and bloating. Extrapolation of the results of a liquid test solution to what may happen with solid foods is, however, fraught with difficulty.…”

Section: Discussionmentioning

confidence: 99%

Small intestinal transit, absorption, and permeability in patients with AIDS with and without diarrhoea

Sharpstone

Neild

Crane

et al. 1999

Gut

114

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Background-Diarrhoea in AIDS is associated with anorexia and weight loss. The importance of gastrointestinal transit in such symptoms has not been addressed. Aims-To assess jejunal to caecal transit times in subjects with AIDS related diarrhoea and weight loss and correlate these with measures of absorptive capacity and intestinal permeability. Conclusion-Small bowel transit is accelerated in many patients with AIDS, particularily in protozoal diarrhoea, but is not the sole explanation for malabsorption of monosaccharides. (Gut 1999;45:70-76)

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Section: Discussionmentioning

confidence: 99%

Small intestinal transit, absorption, and permeability in patients with AIDS with and without diarrhoea

Sharpstone

Neild

Crane

et al. 1999

Gut

114

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“…In diabetic patients, peripheral or autonomic neuropathy is thought to be an important factor in the pathogenesis of gastroparesis (Hongo and Okuno 1993;Farrell and Keeffe 1995;Undeland et al 1996). However, it was reported that it took two weeks to induce motor nerve dysfunction after STZ injection in rats (Inukai et al 1992;Mizuno et al 1992).…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of diabetic gastroparesis, however, remains poorly understood. It was reported that peripheral or autonomic neuropathy was an important factor in gastroparesis in diabetic patients (Hongo and Okuno 1993;Farrell and Keeffe 1995;Undeland et al 1996), but diabetic patients without peripheral or autonomic neuropathy also experience gastroparesis (Horowitz et al 1991), indicating that factors other than neurological impairment can affect gastric emptying. Acute changes in blood glucose levels affected the gastric emptying of a nutrient meal in healthy men (MacGregor et al 1976; Morgan et al 1988;Schirra et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Effects of gastroprokinetic agents on gastroparesis in streptozotocin-induced diabetic rats

Yamano¹,

Kamato²,

Nagakura³

et al. 1997

Naunyn-Schmiedeberg's Arch Pharmacol

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The influence of diabetic hyperglycemia on solid gastric emptying in rats was examined. Diabetes was produced by streptozotocin (STZ, 40 mg/kg i.v.), and diabetic hyperglycemia was observed from 1 day after the STZ injection. The gastric emptying of glass beads in the diabetic rats was significantly delayed compared with that in age-matched control rats at 1, 3 and 7 days after diabetes induction. A slight decrease in gastric emptying was observed in the diabetic rats from 2 to 52 weeks after the diabetes induction. We also investigated the influence of gastroprokinetic agents on STZ-induced diabetic gastroparesis and subdiaphragmatic vagotomy-induced gastroparesis in rats. The selective 5-HT3 receptor antagonists ramosetron (YM060), YM114 (KAE-393), granisetron and ondansetron, and the substituted benzamides (5-HT4 receptor agonist/5-HT3 receptor antagonists) cisapride mosapride and SC-53116 dose-dependently enhanced gastric emptying in normal rats. These compounds also reversed the impairment of diabetic gastroparesis rats at 7 days after the STZ injection, but higher doses were required. The solid gastric emptying in subdiaphragmatic vagotomized rats was also delayed. Ramosetron and the substituted benzamides cisapride and zacopride partially reversed the gastroparesis in the vagotomized rats. These results suggest that acute hyperglycemia is important mechanism for the delay of solid gastric emptying in diabetic rats. It is also suggested that selective 5-HT3 receptor antagonists and substituted benzamides enhance gastric emptying not only in normal rats but also in diabetic and vagotomized rats.

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“…1992; HONGO and OKUNO, 1993;ROTHSTEIN et al, 1993;HASLER et al, 1995;DEBINSKI et al, 1996). Bradygastria, tachygastria, and cell uncoupling have been observed in cutaneous electrode studies of gastric disease states such as gastroparesis ABEII and MALAGELADA et al, 1985;PFISTER et al, 1988;FAMILONI et al, 1991;CHEN and MCCALLUM, 1992;CHEN et al, 1993b), although no conclusive studies validating the existence ofbradygastria and tachygastria with internal recordings have appeared .…”

Section: Fig 1 Movement Of Ions Across the Membrane Of Smooth Musclementioning

confidence: 92%

Volume conductor effects on the spatial resolution of magnetic fields and electric potentials from gastrointestinal electrical activity

Bradshaw

Richards

Wikswo

2001

Med. Biol. Eng. Comput.

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An analysis of the relative capabilities of methods for magnetic and electric detection of gastrointestinal electrical activity is presented. The model employed is the first volume conductor model for magnetic fields from GEA to appear in the literature. A mathematical model is introduced for the electric potential and magnetic field from intestinal electrical activity in terms of the spatial filters that relate the bioelectric sources with the external magnetic fields and potentials. The forward spatial filters are low-pass functions of spatial frequency, so more superficial external fields and potentials contain less spatial information than fields and potentials near the source. Inverse spatial filters, which are reciprocals of the forward filters, are high-pass functions and must be regularised by windowing. Because of the conductivity discontinuities introduced by low-conductivity fat layers in the abdomen, the electric potentials recorded outside these layers required more regularisation than the magnetic fields, and thus, the spatial resolution of the magnetic fields from intestinal electrical activity is higher than the spatial resolution of the external potentials. In this study, two smooth muscle sources separated by 5cm were adequately resolved magnetically, but not resolved electrically. Thus, sources are more accurately localized and imaged using magnetic measurements than using measurements of electric potential.

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Diabetic Gastropathy in Patients with Autonomic Neuropathy

Cited by 16 publications

References 5 publications

Small intestinal transit, absorption, and permeability in patients with AIDS with and without diarrhoea

Small intestinal transit, absorption, and permeability in patients with AIDS with and without diarrhoea

Effects of gastroprokinetic agents on gastroparesis in streptozotocin-induced diabetic rats

Volume conductor effects on the spatial resolution of magnetic fields and electric potentials from gastrointestinal electrical activity

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