Diabetic Gastroparesis and Its Impact on Glycemia

Chang, Jessica; Rayner, Christopher K.; Jones, Karen L.; Horowitz, Michael

doi:10.1016/j.ecl.2010.08.007

Cited by 35 publications

(28 citation statements)

References 94 publications

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“…46 In addition to gastrointestinal symptoms, delayed GE may also predispose to hypoglycemia in type 1 DM. 47 Hence, consideration should be given to evaluating GE in patients with unexplained hypoglycemia without GI symptoms.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and Natural History of Gastroparesis

Bharucha

2015

Gastroenterology Clinics of North America

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Section: Discussionmentioning

confidence: 99%

Epidemiology and Natural History of Gastroparesis

Bharucha

2015

Gastroenterology Clinics of North America

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“…Both of these incretin hormones have strong insulinotropic effects, though they work through different mechanisms - GIP stimulating insulin release and GLP-1 exerting a negative feedback mechanism on gastric emptying [4,7,23,27,32,33,34]. GLP-1 appears to be particularly important in the management of postprandial glycemia in patients with T2DM, since GIP is diminished [35,36].…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

“…Other hormones linked to appetite regulation, including cholecystokinin (CCK) and peptide YY, also appear to influence the gastric emptying rate [7]. The rates of gastric emptying and incretin hormone release have a comingled effect, as gastric empting influences the rate of incretin hormone secretion [32]. Marathe et al [7] asserts that incretin effect is greater when the gastric emptying rate is faster and that the gastric emptying rate is responsible for about 35% of the incretin response in both healthy individuals and those with T2DM.…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

Insulinotropic Effects of Whey: Mechanisms of Action, Recent Clinical Trials, and Clinical Applications

Adams

Broughton

2016

Ann Nutr Metab

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Background: The insulinotropic effect of whey protein is not fully understood and has clinical implications in the regulation of chronic and acute hyperglycemia. Summary: This review describes the composition of whey protein and potential mechanisms through which whey exerts an insulinotropic effect, including increasing the gastric emptying rate, effect on incretin hormones particularly gastric inhibitory peptide and glucagon-like polypeptide-1, and whey's role as a dipeptidyl peptidase IV inhibitor. Recent clinical evidence on the use of whey protein concentrate, isolate and hydrolysate in the management of type 2 diabetes and in the acute care adult population is reviewed. Key Messages: The mechanism through which whey protein exerts its insulinotropic effect is multifactorial. Increasing evidence supports the potential use of whey protein in medical/nutritional therapy to manage glycemia; however, additional research is needed to determine the most appropriate dose, form and delivery method for whey supplementation.

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“…Furthermore, the relative contribution of each of these factors may vary over time during the postprandial state. Nevertheless, both the rate of gastric emptying and the secretion and action of the incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), exert a major influence (6). The latter limit postprandial glycemia through their insulinotropic and, in the case of GLP-1, glucagonostatic actions.…”

mentioning

confidence: 99%