Diabetic Dyslipidemia Review: An Update on Current Concepts and Management Guidelines of Diabetic Dyslipidemia

Dake, Andrew W.; Sora, Nicoleta D.

doi:10.1016/j.amjms.2016.01.020

Cited by 33 publications

(21 citation statements)

References 13 publications

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“…Type 2 diabetes is linked with high cardiovascular morbidity and mortality. Cardiovascular risk in diabetes is determined by dyslipidemia and hypertension [4-5]. …”

Section: Introductionmentioning

confidence: 99%

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Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus

Naqvi

Naveed

Ali

et al. 2017

Cureus

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ContextDyslipidemia is quite prevalent in non-insulin dependent diabetes mellitus. Maintaining tight glycemic along with lipid control plays an essential role in preventing micro- and macro-vascular complications associated with diabetes. PurposeThe main purpose of the study was to highlight the relationship between glycosylated hemoglobin (HbA1c) and triglyceride levels. This may in turn help in predicting the triglyceride status of type 2 diabetics and therefore identifying patients at increased risk from cardiovascular events. Hypertriglyceridemia is one of the common risk factors for coronary artery disease in type 2 diabetes mellitus (DM). Careful monitoring of the blood glucose level can be used to predict lipid status and can prevent most of the complications associated with the disease.MethodThis is a cross-sectional study using data collected from the outpatient diabetic clinic of Jinnah Postgraduate Medical Centre (JPMC) Karachi, Pakistan. Patients of age 18 years and above were recruited from the clinic. A total of consenting 509 patients of type 2 diabetes mellitus were enrolled over a period of 11 months. For statistical analysis, SPSS Statistics for Windows, Version 17.0 ( IBM Corp, Armonk, New York) was used and Chi-square and Pearson’s correlation coefficient was used to find the association between triglyceride and HbA1c. The HbA1c was dichotomized into four groups on the basis of cut-off. Chi-square was used for association between HbA1c with various cut-off values and high triglyceride levels. Odds-ratio and its 95% confidence interval were calculated to estimate the level of risk between high triglyceride levels and HbA1c groups. The p-value < 0.05 was considered statistically significant for all the tests applied for significance.ResultThe association of high triglyceride was evaluated in four different groups of HbA1c, with a cut-off seven, eight, nine and 10 respectively. With HbA1c cut-off value of 7%, 74% patients had high triglycerides and showed a significant association with high triglyceride levels at p < 0.001 and odds ratio was 2.038 (95% confidence interval: 1.397 – 2.972). Logistic regression models were adjusted for demographic factors (age, race, gender), lifestyle factors (smoking, body mass index, lifestyle) and health status factors (blood pressure, physician-rated health status).ConclusionAfter adjusting for relevant covariates, glycated hemoglobin was positively correlated with high triglyceride. Hence, HbA1c can be an indicator of triglyceride level and can be one of the predictors of cardiovascular risk factors in type 2 diabetes mellitus.

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“…Type 2 diabetes is linked with high cardiovascular morbidity and mortality. Cardiovascular risk in diabetes is determined by dyslipidemia and hypertension [4-5]. …”

Section: Introductionmentioning

confidence: 99%

“…It is important to understand the concept of insulin resistance and dyslipidemia predisposing to atherosclerosis [14-15]. Cholesterol lowering through secondary prevention by lifestyle changes or statin therapy has tremendously improved cardiac outcome in diabetes [5]. …”

Section: Introductionmentioning

confidence: 99%

Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus

Naqvi

Naveed

Ali

et al. 2017

Cureus

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“…The number of patients with diabetics is expected to increase from 425 million in 2017 to 693 million by 2045. The leading cause of morbidity and mortality for patients with type 2 diabetes mellitus (T2DM) is cardiovascular diseases (CVDs) [1]. T2DM is associated with an increased risk of macrovascular diseases such as atherosclerosis, coronary heart disease, and peripheral arterial disease [2].…”

Section: Introductionmentioning

confidence: 99%

Distribution Patterns and Risk Factors of Dyslipidemia in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study in Bogor, Indonesia

Pradipta

Wibowo²,

Harbuwono³

et al. 2020

Int J App Pharm

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Objective: Type 2 diabetes mellitus (T2DM) patients tend to have abnormal lipid profiles, explaining the association between elevated cholesterol andtriglyceride levels in diabetic patients and coronary heart disease. This study aims to evaluate how the common risk factors for dyslipidemia affectthe lipid profile of diabetic patients and to determine which factors can be used as predictors for the occurrence of dyslipidemia in T2DM patients.Methods: A total of 238 diabetic patients (63 male and 175 female; age: 31–70 years) were enrolled in this cross-sectional study. All of them hadundergone regular examinations in cohort studies on risk factors for non-communicable diseases conducted by the Ministry of Health in Bogorbetween December 2017 and January 2018.Results: The result found that age differences did not affect lipid profile levels, and the females had higher mean values of body mass index (p<0.001),total cholesterol (TC) (p<0.05), and high-density lipoprotein (HDL) (p<0.001) than the males. The most common occurrences of dyslipidemia werehigh TC level (57.1%), followed by high low-density lipoprotein (LDL) level (47.1%), high triglyceride level (37.4%), and low HDL level (16.4%). Beingoverweight was found to be the best predictor of dyslipidemia.Conclusion: The results of this study suggest that in T2DM patients, sex affects TC and HDL levels, whereas age does not exert a significant effect onthe lipid profiles. In addition, poor glycemic control, hypertension, and obesity may serve as predictors of dyslipidemia in T2DM patients.

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“…In large major complication is linked with all major organ damage leads to morbidity and mortality. [1,2] Diabetic nephropathy (DN) is leading cause of end stage renal disease (ESRD) associated with high rates of morbidity and mortality. [3] Early identification and treatment of nephropathy complication can reduce the medical and economic burden of major damage.…”

Section: Introductionmentioning

confidence: 99%

Variation of Glycosylated Hemoglobin (HbA1C) Cutoff among type-2 diabetic nephropathy Patients

Khan¹,

Ashfaq²

2018

JED

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Objectives:The aim of the study was to determine glycosylated hemogobin (HbA1c) cut-off and lipid correlation, duration of diabetes with level of proteinuria. Materials And Methods:Cross sectional study was done on 250 patients with type-2 diabetes mellitus subjects attending medicine clinic , King george's medical university (KGMU) lucknow, india. Subjects were screened for diabetic nephropathy depending on the base line parameter, clinical history of disease and documented in pretested proforma. Routine blood parameters, HbA1C and 24 hrs urine microalbumin level were carried out in department of pathology.Result: The level of HbA1c was higher among the patients of nephropathy (8.54±0.97) compared with non-nephropathy (7.32±0.84, 95%CI=7.17-7.47). Increased HbA1c was found among both 5-10 and >10 years diabetic duration . However, HbA1c was similar among all duration of diabetes groups within non-nephropathy. The total cholesterol (TC), HDL cholesterol (HDL-c), LDL cholesterol (LDL-c) and VLDL cholesterol (VLDL-C) were almost similar in HbA1c range <7, 7-8.9 and 9-10.9 and without insignificant differences (p>0.05). Although, Triglyceride (TG) level was significantly higher in HbA1c 9-10.9 (174.20±48.95mg%) than 7-8.9 (159.66±31.47mg%) and <7 (158.82±29.67mg%) . High prevalence of nephropathy was found among HbA1c range 9-10.9 (Urine albumin :246.35±126.29mg/d) compared with 7-8.99 (Urine albumin :159.89±70.16mg/d) and <7 (Urine albumin :132.80±90.33mg/d) respectively. Conclusion :HbA1c cut-off >7 % should be considered as an index of glycemic control as well as important tool for over all metabolic derangement and target organ damage among diabetes population. Hence, establishment of HbA1c cut-off value with long duration of diabetes might be useful for prediction of treatment control and prevention of renal failure.

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Diabetic Dyslipidemia Review: An Update on Current Concepts and Management Guidelines of Diabetic Dyslipidemia

Cited by 33 publications

References 13 publications

Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus

Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus

Distribution Patterns and Risk Factors of Dyslipidemia in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study in Bogor, Indonesia

Variation of Glycosylated Hemoglobin (HbA1C) Cutoff among type-2 diabetic nephropathy Patients

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