“…Each question has six answer choices: (1) no problem, (2) slight problem, (3) moderate problem, (4) a somewhat serious problem, (5) a serious problem and (6) a very serious problem. The questionnaire contains four domains: emotional burden (5 items: questions 1, 3, 8, 11 and 14); physician-related distress (4 items: questions 2, 4, 9 and 15); regimen-related distress (5 items: questions 5, 6, 10, 12 and 16) and interpersonal-related distress (3 items: questions 7, 13 and 17) 10. An overall mean score of DRD (four domains) less than 2.0 was considered as little to no distress, a score between 2.0 and 2.9 was considered moderate distress, and a score of 3.0 or higher was considered a high level of distress 10.…”