Diabetic dermopathy: A subtle sign with grave implications

Morgan, Aaron Joseph; Schwartz, Robert A.

doi:10.1016/j.jaad.2007.11.013

Cited by 90 publications

(54 citation statements)

References 17 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diabetic dermopathy and diabetic retinopathy are both considered by some authors as manifestations of diabetic microangiopathy Retinopathy was found to be more common (50%) in patients with dermangiopathy than in those without it (6.2%). [1112]…”

Section: Discussionmentioning

confidence: 99%

An observational study of cutaneous manifestations in diabetes mellitus in a tertiary care Hospital of Eastern India

Chatterjee

Chattopadhyay

Sengupta

et al. 2014

Indian J Endocr Metab

View full text Add to dashboard Cite

Background:Diabetes mellitus and its impact on the human body have been extensively dissected over the years. However, skin which is the largest organ in the body, has received minimum attention. Therefore, this study was designed to analyze the prevalence and pattern of skin disorders among diabetic patients from Eastern region of India.Materials and Methods:This is an observational study, conducted in the General Medicine and Endocrinology departments of a Medical College and Hospital in Eastern India. The data were collected prospectively and systematically in a pre-established proforma designed by us, where clinical findings along with investigations were recorded.Results:Six hundred and eighty (680) diabetic patients were examined, there were (64.8%) male and (35.1%) were female, of them 95.3% were Type 2 diabetics while 4.7% were Type 1. Five hundred and three patients (503) out of six hundred and eighty. i.e. 73.9% were found to have skin lesions. Thirteen (13) (41%) Type1 diabetics demonstrated skin lesions commonest being diabetic xerosis, infections and diabetic hand. Among Type2 diabetics 490(75.61%) showed skin lesions. Here infections, xerosis, hair loss beneath the knees, diabetic dermopathy were the most frequent. Majority of patients (67%) had combination of more than one type of skin lesion. There was statistically significant correlation of skin lesions with duration of diabetes, however similar correlation could not be demonstrated regarding metabolic control.Conclusion:Involvement of skin is inevitable and multifarious in diabetes mellitus. Higher prevalence is seen in Type 2 diabetic population. The duration of diabetes is positively correlated with lesions and infective dermatologic manifestations were associated with higher HbA1C values.

show abstract

Section: Discussionmentioning

confidence: 99%

An observational study of cutaneous manifestations in diabetes mellitus in a tertiary care Hospital of Eastern India

Chatterjee

Chattopadhyay

Sengupta

et al. 2014

Indian J Endocr Metab

View full text Add to dashboard Cite

show abstract

“…Diabetic dermopathy is a cutaneous manifestation of diabetic microangiopathy . This is a subtle sign but has been proposed as an unfavourable association with three common diabetic microangiopathic complications, namely neuropathy, nephropathy and retinopathy . Brown spots on the legs are significantly higher present in the residents with hypertension, hyperlipidaemia and kidney diseases, which have microangiopathies in pathophysiology .…”

Section: Discussionmentioning

confidence: 99%

High prevalence of cutaneous manifestations in the elderly with diabetes mellitus: an institution‐based cross‐sectional study in Taiwan

Tseng

Ger

Liang

et al. 2014

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…However, the most frequently diagnosed complications in diabetic patients are related to the microcirculation, including foot ulcers [7], retinopathy [8], neuropathy [9], diabetic dermopathy [10] and diminished wound healing [11]. These diabetes-related microvascular dysfunctions can eventually lead to more severe complications, illustrating the necessity to detect microvascular dysfunction in an early stage and identify diabetic patients at risk.…”

Section: Introductionmentioning

confidence: 99%

The association between diabetes and dermal microvascular dysfunction non-invasively assessed by laser Doppler with local thermal hyperemia: a systematic review with meta-analysis

Fuchs

Dupon

Schaap

et al. 2017

Cardiovasc Diabetol

100

View full text Add to dashboard Cite

Background/IntroductionDiabetes and cardiovascular disease develop in concert with metabolic abnormalities mirroring and causing changes in the vasculature, particularly the microcirculation. The microcirculation can be affected in different parts of the body of which the skin is the most easily accessible tissue.PurposeThe association between diabetes and dermal microvascular dysfunction has been investigated in observational studies. However, the strength of the association is unknown. Therefore we conducted a systematic review with meta-analysis on the association between diabetes and dermal microvascular dysfunction as assessed by laser Doppler/laser speckle contrast imaging with local thermal hyperaemia as non-invasive indicator of microvascular functionality.Methods PubMed and Ovid were systematically searched for eligible studies through March 2015. During the first selection, studies were included if they were performed in humans and were related to diabetes or glucose metabolism disorders and to dermal microcirculation. During the second step we selected studies based on the measurement technique, measurement location (arm or leg) and the inclusion of a healthy control group. A random effects model was used with the standardised mean difference as outcome measure. Calculations and imputation of data were done according to the Cochrane Handbook.ResultsOf the 1445 studies found in the first search, thirteen cross-sectional studies were included in the meta-analysis, comprising a total of 857 subjects. Resting blood flow was similar between healthy control subjects and diabetes patients. In contrast, the microvascular response to local skin heating was reduced in diabetic patients compared to healthy control subjects [pooled effect of −0.78 standardised mean difference (95% CI −1.06, −0.51)]. This effect is considered large according to Cohen’s effect size definition. The variability in effect size was high (heterogeneity 69%, p < 0.0001). However, subgroup analysis revealed no difference between the type and duration of diabetes and other health related factors, indicating that diabetes per se causes the microvascular dysfunction.ConclusionOur meta-analysis shows that diabetes is associated with a large reduction of dermal microvascular function in diabetic patients. The local thermal hyperaemia methodology may become a valuable non-invasive tool for diagnosis and assessing progress of diabetes-related microvascular complications, but standardisation of the technique and quality of study conduct is urgently required.Electronic supplementary materialThe online version of this article (doi:10.1186/s12933-016-0487-1) contains supplementary material, which is available to authorized users.

show abstract

Diabetic dermopathy: A subtle sign with grave implications

Cited by 90 publications

References 17 publications

An observational study of cutaneous manifestations in diabetes mellitus in a tertiary care Hospital of Eastern India

An observational study of cutaneous manifestations in diabetes mellitus in a tertiary care Hospital of Eastern India

High prevalence of cutaneous manifestations in the elderly with diabetes mellitus: an institution‐based cross‐sectional study in Taiwan

The association between diabetes and dermal microvascular dysfunction non-invasively assessed by laser Doppler with local thermal hyperemia: a systematic review with meta-analysis

Contact Info

Product

Resources

About