Diabetic Cataracts and Flavonoids

Varma, Shambhu D.; Mizuno, A; Kinoshita, Jin H.

doi:10.1126/science.401544

Cited by 178 publications

(63 citation statements)

References 4 publications

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“…The end result is cell death by apoptosis. 15 Several nutritional scavengers of ROS such as ascorbate, 16 tocopherols, 17 , 18 and biofl avonoids 19 have been shown to protect the lens against such damage. There is some evidence that they have an attenuating effect against formation of cataracts in humans also.…”

Section: Introductionmentioning

confidence: 99%

Prevention of Oxidative Damage to Lens by Caffeine

Varma

Hegde

2010

Journal of Ocular Pharmacology and Therapeutics

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Purpose: The primary objective of this study was to examine the possibility of inhibiting oxidative damage to the lens in vitro by caffeine. Methods: Oxidative damage was infl icted by incubating mouse lenses in Tyrode medium containing 0.1 mM Fe 8 Br 8 , an iron complex soluble in aqueous medium. Parallel incubations were conducted in the presence of caffeine (5 mM). Results: Lenses incubated in the medium containing Fe 8 Br 8 undergo oxidative stress, as evidenced by the inhibition of Na + -K + ATPase-driven rubidium transport and the loss of tissue glutathione and ATP. These effects were prevented in presence of caffeine. That the effects are due to the oxyradicals produced was ascertained further by parallel studies with Tempol (5 mM), a well-known scavenger of reactive oxygen species (ROS) with its activity being more pronounced with hydroxyl radicals as compared to other ROS. Conclusions: Caffeine was found to be effective in preventing oxidative stress to the lens induced by iron under ambient conditions. The protective effect is attributable to its ability to scavenge ROS, particularly the hydroxyl radical.

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Section: Introductionmentioning

confidence: 99%

Prevention of Oxidative Damage to Lens by Caffeine

Varma

Hegde

2010

Journal of Ocular Pharmacology and Therapeutics

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“…The infrared spectrum of Gallic acid (Cf 2 ) showed a stretching vibration of -OH at 3464. corresponding to a vibration of the O-H deformation. Mass spectrum (EIMS 70 eV) analysis of Cf 2 presents the molecular ion at m/z 170, coincident with the molecular formula of a phenolic acid such as Gallic acid (C 7 H 6 O 5 ), with a relative intensity of 100%, which also corresponds to the base peak, characteristic of phenols whose molecular ion peak is also its base [52][53][54][55][56][57][58][59][60][61][62] Tables 2 and 3 shows the Cf 2 mass spectrum data. Figures 5-7 shows the mass spectrum of Gallic acid.…”

Section: Separation and Identification Of Phenolic Compounds By Chrommentioning

confidence: 99%

Isolation of Catechin and Gallic Acid from Colombian Bark of Pinus patula

Sarria-Villa¹,

Corredor²,

Páez³

2017

Chem Sci J

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Pine bark is a rich source of natural polyphenols, compounds which have attracted increasing attention in the fields of nutrition, health and medicine. Extractive components include large amounts of phenolic compounds. The ethanolic extract was obtained from Pinus patula bark grown in the forests of the Cauca Department in Colombia South America. The Gallic acid, catechin, epicatechin and procyanidin B2 contents in ethanolic extract were 3.12, 1.99, 0.80, and 0.71%, respectively, these compounds were determined using HPLC with UV-Vis detection. Ethanolic extract was divided using column chromatography to obtain an ethanol-soluble fraction with tannins and phlobaphenes as well as an ethanol-insoluble fraction mainly composed of Phenolic acids. Catechin and Gallic acid finally isolated were characterized using UV-Vis, IR, NMR, 13 C, 1 H, HSQC, HMBC and GC-MS spectrometry.

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“…Perflavone has been suggested to be useful in the treatment of angina, atherosclerosis and myocardial infarction (Wagner, 1977). The cataract observed in diabetic and galactosemic conditions can be treated by flavonoids as they inhibit the enzyme aldose reductase in the lens (Varma et al, 1977;Parmar and Ghosh, 1979). Gastric anti-ulcer effect of various flavonoids has been extensively studied by Parmar (1977).…”

Section: Flavonoids In the Treatment Of Diseasesmentioning

confidence: 99%