Diabetic cardiomyopathy – Zinc preventive and therapeutic potentials by its anti-oxidative stress and sensitizing insulin signaling pathways

The signaling pathways of selected traditional Chinese medicine prescriptions and their metabolites in the treatment of diabetic cardiomyopathy: a review

“…Although the pathogenesis of DCM is complex, after long-term exploration, scholars generally believe that the occurrence and development of DCM is mainly related to glucose and lipid metabolism disorders, microvascular endothelial dysfunction, apoptosis, advanced glycation end product (AGE) deposition, myocardial inflammation, and oxidative stress. Under the influence of the crosstalk of the above factors, it will lead to increased myocardial oxygen consumption, myocardial fibrosis, increased metabolic pressure, significantly reduced cardiac efficiency and function, and ultimately DCM ( Huo et al, 2021 ; Wang et al, 2022 ; Wu et al, 2023 ; Cai et al, 2023 ; Zhou et al, 2023 ). Currently, there is no specific treatment or preventative drug for DCM.…”

Invited Perspective: New Insight into Cadmium-Related Osteoporosis Yields Hope for Prevention and Therapy

“…Furthermore, not only have several in vitro studies with osteoblastic cell lines 28 , 42 – 44 shown that SFN or zinc exhibited preventive effects on the cytotoxicity caused by different kinds of stresses, but numerous in vivo studies with animal models also showed the preventive effects of either zinc or Nrf2 activators, including SFN, on bone injury or loss caused by several pathologies. 44 – 46 We also know these agents may protect against the complications of both type 1 and type 2 diabetes—SFN via activation of Nrf2 function, 47 – 50 zinc via induction of MT expression, 37 , 51 , 52 and SFN and zinc synergistically. 53 , 54 Diabetes is a major risk factor for osteoporosis, most likely via oxidative stress.…”