Diabetes specific tube feed results in improved glycaemic and triglyceridaemic control during 6h continuous feeding in diabetes patients

Improved Glucose Profile in Patients With Type 2 Diabetes With a New, High‐Protein, Diabetes‐Specific Tube Feed During 4 Hours of Continuous Feeding

“…Mean blood glucose levels were reduced by 15% (–1.7 mmol/L) with the DSF, which is comparable to the 12% (–1.0 mmol/L) reduction observed in the current study. In a randomized, controlled, double‐blind, crossover study of 12 patients with type 2 diabetes in which the diabetes‐specific (and standard) formula was administered during 6 hours, no average blood glucose levels are shown 18 . In this study, the delta peak glucose concentration was 1.5 mmol/L lower during DSF feeding.…”

“…Another limitation of the current study may be that the feeding period was only 4 hours. However, another study with continuous tube feeding showed that steady‐state plasma glucose levels were reached after 2–3 hours of administration 18 . Finally, no insulin was used to control blood glucose levels in the current study.…”

“…Sample size calculations were based on the parameter change from baseline in plasma glucose levels in the 3‐ to 4‐hour period. Assuming a 30% reduction in the plasma glucose levels (a mean [SD] difference between the products of 0.855 [1.295] mmol/L based on earlier work 18 ) of the test product vs control product, 20 patients would be required for a statistical power of 0.8, using an α of 0.05 in a 2‐sided paired t test. Assuming a dropout rate of 15%, 24 patients needed to be included in the study.…”

A Diabetes-specific Oral Nutritional Supplement Improves Glycaemic Control in Type 2 Diabetes Patients

“…monounsaturated fatty acids (MUFA), medium-chain triglycerides (MCT), dietary fibre, starch, and fructose. A large number of studies in patients with type 2 diabetes as well as a systematic review indicate that the administration of low carbohydrate, high MUFA enteral formulae is associated with improved glycaemic control, without posing a risk to lipid metabolism [12][13][14][15][16][17][18][19]. However, experience is still limited for long-term intervention with diabetes-specific oral nutritional supplements (ONS) [12].…”

The use of specialised enteral formulae for patients with diabetes mellitus

“…Depending on the total energy and carbohydrate intake, as well as the individual response to the diet, saturated fat can therefore be replaced by either unsaturated fatty acid or carbohydrate. 1,2,7 Studies comparing diabetes-specific formulae with standard formulae have reported a neutral effect on glucose control and lipid management 14 ; a reduction in peak glucose values 15,16,17 ; a reduced HbA1c profile 15,16 ; lower postprandial glucose values 18 ; reduced insulin requirements 16 and no significant effect on lipid values. 14,16,18 Unfortunately, due to relatively small patient numbers and short duration of studies, as well as different feed compositions, it is difficult to compare results and to determine the clinical impact of the outcomes.…”