Diabetes, Sleep Apnea, and Glucose Control

Aronsohn, Renee S.; Whitmore, Heidi; Cauter, Eve Van; Tasali, Esra

doi:10.1164/ajrccm.182.2.287a

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Sleep deprivation influences the immune, endocrine, and nervous systems 15 . It leads to poor glycemic control 16 and influences body metabolism 17 .…”

Section: Introductionmentioning

confidence: 99%

Obstructive Sleep Apnea: Evaluation of high risk individuals, knowledge and associated factors among a representative sample of Lebanese adults

Choucair¹,

Malaeb²,

Hallit³

et al. 2020

Preprint

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Background: To date, there has been no large population-based study about Obstructive Sleep Apnea (OSA) in Lebanon. Our study evaluated high risk individuals, knowledge and associated factors of OSA among a representative sample of Lebanese adults. Methods: A cross-sectional study, conducted between June and August 2019, enrolled 472 people aged above 18. A proportionate random sample from all Lebanese Governorate was applied. Each governorate is divided into Caza (stratum), which in turn is divided into multiple villages. Two villages were selected randomly from the list of villages provided by the Central Agency of Statistics in Lebanon. Households were randomly selected from each village using an online software.Results: The percentage of physician-diagnosed sleep apnea in our sample was 11%; 159 (33.7%) had poor knowledge (scores ≤11), whereas 165 (35.0%) and 148 (31.4%) had moderate (scores between 12 and 15) and good (scores ≥16) knowledge respectively. The study results showed that -according to the Epworth Scale- having diabetes mellitus, myocardial infarction, arrhythmia, and hypertension were associated with higher daytime sleepiness. Furthermore, mild, moderate and severe excessive daytime sleepiness (EDS) percentages were 14.4%, 16.3% and 13.8% respectively. According to the STOP-BANG questionnaire, 31.6% of participants had an intermediate risk of OSA and 7.6% had a high risk. Diabetic patients and those with myocardial infarction were significantly associated with higher STOP BANG scores.Concerning knowledge, having heard about sleep apnea was associated with a higher knowledge score. Overall, 31.4% of the participants had a good score. Conclusion The actual study proves that EDS which has adverse health effects, is associated with multiple morbidities. Besides, the general population isn’t aware enough of this disease. Comparing the rate of high-risk individuals to the physician-diagnosed ones, we conclude that in Lebanon, OSA is likely prevalent but underdiagnosed. Ongoing health campaigns and screenings should be assigned to target the general community.

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“…Sleep deprivation influences the immune, endocrine, and nervous systems 15 . It leads to poor glycemic control 16 and influences body metabolism 17 .…”

Section: Introductionmentioning

confidence: 99%

Obstructive Sleep Apnea: Evaluation of high risk individuals, knowledge and associated factors among a representative sample of Lebanese adults

Choucair¹,

Malaeb²,

Hallit³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Association of snoring with cardiovascular disease suggests that even a mild degree of sleep-disordered breathing may have adverse health effects 14,15 . Lack of sleep has an effect on the immune, endocrine and nervous systems 16 and is associated with poor glycemic control 17 . Afterwards, insufficient sleep is an influencer of body metabolism 18 .…”

Section: Introductionmentioning

confidence: 99%

Obstructive Sleep Apnea among the Lebanese general population: Prevalence, associated factors and knowledge

Choucair

Malaeb

Hallit

et al. 2020

Preprint

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Background : To date, there has been no large population-based study associated with public awareness in Lebanon about sleep apnea. Our study investigated the prevalence of, associated factors and knowledge of Obstructive Sleep Apnea (OSA) among a representative sample of Lebanese adults. Methods: A cross-sectional study, conducted between June and August 2019, enrolled 472 people aged above 18 years. A proportionate random sample from all Lebanese Mohafazat was applied. Results: The study results showed that a higher number of cigarettes per day, having diabetes mellitus, myocardial infarction, hypertension and arrhythmia were associated with higher daytime sleepiness. Participants living in the North had less daytime sleepiness, whereas those living in Beqaa had higher daytime sleepiness compared to those living in Beirut. Concerning knowledge, having heard about sleep apnea and having a university level of education were associated with a higher score, whereas having cerebrovascular accidents was associated with lower knowledge scores. Conclusion Complications of OSA are still poorly known, as are certain suggestive symptoms. Given the local relevance of OSA, ongoing health campaigns and innovative educational programs should be assigned to target the general community.

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Endothelial Dysfunction in the Microcirculation of Patients with Obstructive Sleep Apnea

Patt¹,

Jarjoura²,

Haddad³

et al. 2010

Am J Respir Crit Care Med

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Rationale: Obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease. We hypothesized that patients with OSA and no cardiovascular disease have oxidant-related microcirculatory endothelial dysfunction. Objectives: To evaluate the microcirculation in OSA. Methods: This study included seven patients with OSA and seven ageand weight-matched control subjects (mean age, 38 yr; mean body mass index, 32.5 kg/m 2 ). All participants were free of cardiovascular risk factors. Participants received measurement of brachial artery flow-mediated dilation and forearm subcutaneous biopsy. Patients underwent repeated tests 12 weeks after treatment. Microcirculatory endothelial cells were isolated, and immunohistochemistry staining for peroxynitrite in the microcirculation was performed. Measurements and Main Results: Flow-mediated dilation was lower in patients than in control subjects at baseline (mean 6 SEM: 5.7 6 0.5 vs. 9.5 6 0.6; P 5 0.02) and increased after treatment (5.7-7.3; change, 1.7 6 0.6; P 5 0.04). Microcirculatory peroxynitrite deposit was higher in patients compared with control subjects (44.0 6 1.6 vs. 21.8 6 1.9 stain density units; P , 0.001) and decreased after treatment from 44.0 to 30.5 stain density units (change, 213.5 6 2.9; P 5 0.009). In patients, transcription of endothelial nitric oxide synthase decreased from 5.2 to 21.3 after treatment (change, 6.5 6 2.5; P 5 0.05), and transcription of superoxide dismutase1 decreased from 24.0 to 212.3 after treatment (change, 28.3 6 2.1; P 5 0.01). These changes persisted after adjustment for weight and underlying severity of OSA. Conclusions: This is the first direct evaluation of the microcirculation in OSA. Patients with OSA with low cardiovascular risk status had increased oxidant production in the microcirculation and endothelial dysfunction, both of which improved with treatment. Endothelial nitric oxide synthase transcription decreased with treatment.

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Diabetes, Sleep Apnea, and Glucose Control

Cited by 3 publications

References 9 publications

Obstructive Sleep Apnea: Evaluation of high risk individuals, knowledge and associated factors among a representative sample of Lebanese adults

Obstructive Sleep Apnea: Evaluation of high risk individuals, knowledge and associated factors among a representative sample of Lebanese adults

Obstructive Sleep Apnea among the Lebanese general population: Prevalence, associated factors and knowledge

Endothelial Dysfunction in the Microcirculation of Patients with Obstructive Sleep Apnea

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