Diabetes risk score in the diagnostic categories of polycystic ovary syndrome

Moran, Lisa J.; Strauss, Boyd Josef Gimnicher; Teede, Helena

doi:10.1016/j.fertnstert.2011.01.133

Cited by 39 publications

(37 citation statements)

References 41 publications

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“…Unfortunately, this analysis was not done because our sample was too small for that aim. In addition, the roles of the different phenotypes of PCOS on the metabolic pattern are still debated (19–23). …”

Section: Discussionmentioning

confidence: 99%

The Risk of a Persistent Glucose Metabolism Impairment After Gestational Diabetes Mellitus Is Increased in Patients With Polycystic Ovary Syndrome

et al. 2012

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OBJECTIVETo test the hypothesis that the risk of persistent glucose impairment after gestational diabetes mellitus (GDM) is increased in patients with polycystic ovary syndrome (PCOS).RESEARCH DESIGN AND METHODSThe prospective case-control study included 42 pregnant patients with PCOS and GDM and 84 pregnant control patients with GDM but without clinical and biochemical hyperandrogenism, polycystic ovaries, and oligo-anovulation. The case and control subjects were matched one to two for age and BMI. The glycemic profiles were studied in all subjects 6 weeks, 12 weeks, and 18 months after delivery. The incidence and the relative risk (RR) were calculated for overall persistence of an abnormal glycemic pattern and for each specific alteration, i.e., impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and diabetes mellitus (DM).RESULTSAt 18 months after delivery, the incidences of IFG, IGT, and IFG-IGT were significantly (P < 0.05) higher in the cases than in the controls. At the 18-month follow-up, the RR for the composite outcome of glucose metabolism impairment in PCOS women was 3.45 (95% CI 1.82–6.58).CONCLUSIONSPatients with PCOS are at increased risk for a persistent impaired glucose metabolism after GDM.

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Section: Discussionmentioning

confidence: 99%

The Risk of a Persistent Glucose Metabolism Impairment After Gestational Diabetes Mellitus Is Increased in Patients With Polycystic Ovary Syndrome

et al. 2012

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“…These subjects were not classified according to the Rotterdam criteria and further work needs to be undertaken to define whether the differing PCOS phenotypes are associated with IFG, IGT, or CGI. It has recently been shown that women with NIH and non-NIH PCOS have similar Finnish Diabetes Risk Scores and increased scores relative to controls independent of age and adiposity (48).…”

Section: Ir and Pcosmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Recent advances in cardiovascular aspects of polycystic ovary syndrome

Sathyapalan

Atkin²

2012

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) has been associated with increased cardiovascular risk (CVR) markers, but population studies have not clarified whether there is an increase in cardiovascular morbidity and mortality. Four different PCOS phenotypes resulted from the Rotterdam criteria that may differ in their CVR potential, thus introducing further complexity. This has led to studies using surrogate CVR markers including biomarkers in blood and imaging such as flow-mediated vasodilatation. In PCOS, both peripheral and central insulin resistance (IR) have been shown. Weight loss has been shown to improve IR and visceral fat, while insulin sensitizer therapies with metformin or thiazolidinediones improve IR and endothelial dysfunction. IR is also found in non-alcoholic fatty liver disease that in turn is very common in PCOS; studies have suggested that IR may be improved by treatment with metformin and omega-3 fish oils. PCOS patients have a more dyslipidemic phenotype that is worse in 'classical PCOS' associated with a higher CVR. Studies with atorvastatin and simvastatin have reported a decrease in the lipid parameters and an improvement in CVR indices including IR, but it is unclear whether this is due to their lipid-lowering action or a pleiotropic effect of the statin. In this expert opinion review, the relevant literature published during the last 2 years was considered. It focuses on some recent important data that has emerged while also exposing the gaps that remain in our knowledge that need to be addressed.

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“…Women with PCOS have intrinsic insulin resistance (IR) and compensatory hyperinsulinaemia that is independent of, but exacerbated by obesity . Insulin resistance can predispose women with PCOS to diabetes, metabolic syndrome and cardiovascular disease (CVD) risk factors including dyslipidaemia, hypertension and impaired glucose tolerance and is thought to drive hyperandrogenism in PCOS, underpinning the metabolic and reproductive features of the condition . Altered insulin sensitivity in PCOS can be attributed to insulin receptor and/or postbinding defect in the insulin signalling pathways .…”

Section: Introductionmentioning

confidence: 99%

Biomarkers and insulin sensitivity in women with Polycystic Ovary Syndrome: Characteristics and predictive capacity

Cassar

Teede

Harrison

et al. 2014

Clinical Endocrinology

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Diabetes risk score in the diagnostic categories of polycystic ovary syndrome

Cited by 39 publications

References 41 publications

The Risk of a Persistent Glucose Metabolism Impairment After Gestational Diabetes Mellitus Is Increased in Patients With Polycystic Ovary Syndrome

The Risk of a Persistent Glucose Metabolism Impairment After Gestational Diabetes Mellitus Is Increased in Patients With Polycystic Ovary Syndrome

MECHANISMS IN ENDOCRINOLOGY: Recent advances in cardiovascular aspects of polycystic ovary syndrome

Biomarkers and insulin sensitivity in women with Polycystic Ovary Syndrome: Characteristics and predictive capacity

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