Diabetes Prevention Programs

Ramachandran, Ambady; Snehalatha, C.

doi:10.1016/j.mcna.2010.11.006

Cited by 29 publications

(32 citation statements)

References 79 publications

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“…Examples of these modifications have included a reduced number of group sessions [11,20,22,28,29], culturally-adapted curricula [15,20,21,28,30,31], and allocation of the intervention by site rather than at the individual level for experimental study designs [12,23,32,33]. The DPP program has also demonstrated positive results in Japan, India, Finland, and China [34]. In the U.S., the DPP has been undertaken in few Asian American communities [28], none of which have been South Asian.…”

Section: Introductionmentioning

confidence: 99%

Diabetes Prevention in the New York City Sikh Asian Indian Community: A Pilot Study

Islam

Zanowiak

Wyatt

et al. 2014

IJERPH

148

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India has one of the highest burdens of diabetes worldwide, and rates of diabetes are also high among Asian Indian immigrants that have migrated into the United States (U.S.). Sikhs represent a significant portion of Asian Indians in the U.S. Diabetes prevention programs have shown the benefits of using lifestyle intervention to reduce diabetes risk, yet there have been no culturally-tailored programs for diabetes prevention in the Sikh community. Using a quasi-experimental two-arm design, 126 Sikh Asian Indians living in New York City were enrolled in a six-workshop intervention led by community health workers. A total of 108 participants completed baseline and 6-month follow-up surveys between March 2012 and October 2013. Main outcome measures included clinical variables (weight, body mass index (BMI), waist circumference, blood pressure, glucose, and cholesterol) and health behaviors (changes in physical activity, food behaviors, and diabetes knowledge). Changes were significant for the treatment group in weight, BMI, waist circumference, blood pressure, glucose, physical activity, food behaviors, and diabetes knowledge, and between group differences were significant for glucose, diabetes knowledge, portion control, and physical activity social interaction. Retention rates were high. Findings demonstrate that a diabetes prevention program in the Sikh community is acceptable, feasible, and efficacious.

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Section: Introductionmentioning

confidence: 99%

Diabetes Prevention in the New York City Sikh Asian Indian Community: A Pilot Study

Islam

Zanowiak

Wyatt

et al. 2014

IJERPH

148

View full text Add to dashboard Cite

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“…In addition, the drug enhances both peripheral glucose uptake and fatty acid oxidation (1). The Diabetes Prevention Trial demonstrated that metformin decreased the incidence of diabetes development in at risk populations by ~30% (2).…”

Section: Introductionmentioning

confidence: 99%

Metformin inhibits leptin-induced growth and migration of glioblastoma cells

2012

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Abstract. Metformin, a derivative of biguanide, is a first-line therapy for type 2 diabetes mellitus. Since the drug has been shown to significantly reduce the risk of various cancers and cancer mortality in diabetic patients, it is being considered as a potential anticancer therapeutic or preventive agent. In cellular models, metformin inhibits the growth of many types of cancer cells; however, its effects on glioblastoma multiforme (GBM) are not well characterized. Here, we analyzed the effects of metformin on the growth and migration of LN18 and LN229 GBM cells cultured under basal conditions or exposed to leptin, a cytokine that has recently been implicated in GBM development. We found that 2-16 mM metformin reduced basal and leptin-stimulated growth of GBM cells in a dose-dependent manner. Furthermore, the drug significantly inhibited the migration of GBM cells. The action of metformin was mediated through the upregulation of its main signaling molecule, the adenosine monophosphate-activated protein kinase (AMPK), as well as through the downregulation of the signal transducer and activator of transcription 3 (STAT3) and the Akt/PKB serine/threonine protein kinase. In leptin-treated cells, the drug reversed the effects of the cytokine on the AMPK and STAT3 pathways, but modulated Akt activity in a cell-dependent manner. Our results suggest that metformin or similar AMPK-targeting agents with optimized bloodbrain-barrier penetrability could be developed as potential treatments of GBM and could be used in conjunction with other target drugs such as leptin receptor antagonists.

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“…28 Weight reduction was not a major determinant of benefit and the subjects were mostly lean with high insuline resistance (IR). 45 Nevertheless, subjects with high IR and low BMI also benefited from LSM. 46,47 In India, the estimated treatment cost of diabetes is $ 140-150/person/year.…”

Section: Feasibility Of Prevention Programsmentioning

confidence: 99%

Primary prevention of diabetes mellitus: current strategies and future trends

Bhattacharya¹,

Roy²

2016

Ital J Med

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Aim of this paper is to find evidence for primary prevention of type-2 diabetes mellitus (T 2 DM) from epidemiological studies and clinical trials, and the feasibility of applying these interventions in resource limited countries. T 2 DM, which accounts for more than nine-tenths of all diabetics, results from inadequate insulin secretion or underlying insulin resistance. The prevalence of diabetes, mainly T 2 DM, has increased rapidly during the last few decades worldwide. Since the genetic background is unlikely to change during this short time period, the growing epidemic of T 2 DM is more likely due to changes in environmental or lifestyle risk factors including obesity, physical inactivity, smoking, alcohol and stress. The scope and feasibility for primary prevention of T 2 DM is based on elimination of these risk factors. This evidence that T 2 DM is preventable comes from epidemiologic studies and clinical trials of effect of lifestyle changes and drugs in development of T 2 DM. The positive effects are more profound and safer with lifestyle modifications (LSM) compared to medications. This is shown to be effective globally, across various ethnicities and races and sustainable on long-term follow-up. However, there is a major challenge in translating this evidence into economically viable and sustained community programs, as these LSM interventions are expensive, even from western standards point of view. Future plan should focus on health education of the public, improving the national capacity to detect and manage the environmental risks including strategies to reduce stress, and development of innovative, cost effective, and scalable methodologies.

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Diabetes Prevention Programs

Cited by 29 publications

References 79 publications

Diabetes Prevention in the New York City Sikh Asian Indian Community: A Pilot Study

Diabetes Prevention in the New York City Sikh Asian Indian Community: A Pilot Study

Metformin inhibits leptin-induced growth and migration of glioblastoma cells

Primary prevention of diabetes mellitus: current strategies and future trends

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