Diabetes mellitus triggers oxidative stress in the liver of alloxan-treated rats: a mechanism for diabetic chronic liver disease

Lucchesi, Amanda Natália; Freitas, Natália Tavares de; Cassettari, Lucas Langoni; Marques, Silvio Fernando Guideti; Spadella, César Tadeu

doi:10.1590/s0102-86502013000700005

Cited by 96 publications

(74 citation statements)

References 32 publications

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“…Accumulating laboratory evidence suggests that insulin resistance and excess of free fatty acids can trigger the oxidative stress in hepatocytes and lead to chronic inflammation and fibrogenesis [13,14] . Hepatic fibrogenesis is the final consequences of chronic liver disease and constitutes a model of wound-healing process.…”

Section: Hepatic Fibrogenesis Developmentmentioning

confidence: 99%

Proteomic and genomic studies of non-alcoholic fatty liver disease - clues in the pathogenesis

Lim

Dillon

Miller

2014

WJG

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Non-alcoholic fatty liver disease (NAFLD) is a widely prevalent hepatic disorder that covers wide spectrum of liver pathology. NAFLD is strongly associated with liver inflammation, metabolic hyperlipidaemia and insulin resistance. Frequently, NAFLD has been considered as the hepatic manifestation of metabolic syndrome. The pathophysiology of NAFLD has not been fully elucidated. Some patients can remain in the stage of simple steatosis, which generally is a benign condition; whereas others can develop liver inflammation and progress into non-alcoholic steatohepatitis, fibrosis, cirrhosis and hepatocellular carcinoma. The mechanism behind the progression is still not fully understood. Much ongoing proteomic researches have focused on discovering the unbiased circulating biochemical markers to allow early detection and treatment of NAFLD. Comprehensive genomic studies have also begun to provide new insights into the gene polymorphism to understand patientdisease variations. Therefore, NAFLD is considered a complex and mutifactorial disease phenotype resulting from environmental exposures acting on a susceptible polygenic background. This paper reviewed the current status of proteomic and genomic studies that have contributed to the understanding of NAFLD pathogenesis. For proteomics section, this review highlighted functional proteins that involved in: (1) transportation; (2) metabolic pathway; (3) acute phase reaction; (4) antiinflammatory; (5) extracellular matrix; and (6) immune system. In the genomic studies, this review will discuss genes which involved in: (1) lipolysis; (2) adipokines; and (3) cytokines production. Key words: Non-alcoholic fatty liver disease; Proteomics; Genomics; Metabolic syndrome; Pathophysiology Core tip: Non-alcoholic fatty liver disease (NAFLD) is a widely prevalent hepatic disorder in Western populations. NAFLD can occur as a spectrum diseases, from simple steatosis, to non-alcoholic steatohepatitis characterised by hepatocellular injury and inflammation, to cirrhosis and hepatocellular carcinoma. This paper reviewed the current status of proteomic and genomic studies that have contributed to the understanding of NAFLD pathogenesis. This review highlighted several functional proteins and genetic polymoprhisms; particular those involved in insulin resistance, triglycerides metabolism and hepatic inflammation. It is hoped that this review will offer further insights into the pathophysiology of NAFLD.

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Section: Hepatic Fibrogenesis Developmentmentioning

confidence: 99%

Proteomic and genomic studies of non-alcoholic fatty liver disease - clues in the pathogenesis

Lim

Dillon

Miller

2014

WJG

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“…The number of individuals affected by DM is increasing all over the world because of physical inactivity, increased prevalence of obesity, urbanization and population aging. Hyperglycemia is associated with the production of reactive oxygen species (ROS) and with the lowering of antioxidant capacity, which play an important role in the oxidative damage especially in the liver, kidneys, eyes, nerves, pancreas and blood vessels (2,5,7,24,37).…”

mentioning

confidence: 99%

Protective effects of Quercetin and chronic moderate exercise (training) against oxidative stress in the liver tissue of streptozotocin-induced diabetic rats

Chiş

Muresan

Oros

et al. 2016

Acta Physiologica Hungarica

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Background: To investigate the protective effects of Quercetin administration associated with chronic moderate exercise (training) on oxidative stress in the liver in streptozotocin-induced diabetic rats. Methods: Diabetic rats that performed exercise training were subjected to a swimming training program (1 hour/day, 5 days/week, 4 weeks). The diabetic rats received natural antioxidant, Quercetin (20 mg/kg body weight/day) for 4 weeks. At the end of the study, all animals were sacrificed and liver samples were collected for estimation: some oxidative stress markers (malondialdehyde, MDA and protein carbonyls groups, PC), the activity of antioxidant enzymes (superoxide dismutase, SOD and catalase, CAT), reduced glutathione (GSH) level and reduced (GSH) and oxidized (GSSG) glutathione ratio. Results: Diabetic rats submitted to exercise training showed significantly increased the oxidative stress markers (MDA and PC) and a reduction of antioxidant enzyme (SOD and CAT) activity, GSH level and GSH/ GSSG ratio in hepatic tissues. A decrease in the levels of oxidative stress markers associated with elevated activity of antioxidant enzymes, the GSH level and GSH/GSSG ratio in the hepatic tissue were observed in Quercetin-treated diabetic trained rats. Conclusions: These findings suggest that Quercetin administration in association with chronic moderate exercise exerts a protective effect in diabetes by attenuating hyperglycemia-mediated oxidative stress in hepatic tissue.

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“…There is a positive relationship between oxidative stress and hyperglycemia. The oxidative unbalance in hepatocytes can cause the development of the liver disease in diabetes (36) . GSH can inhibit free radical-mediated injury by eliminating reactive oxygen species.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Ghrelin Treatment on Cell Survival and Inflammation in Type 2 Diabetic Rat Liver

Coşkun¹,

Beydogan²,

Bolkent³

2017

Okmeydani Medical Journal

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, nuclear factor kappa B (NF-κB), peroxisome proliferatoractivated receptor gamma and proliferating cell nuclear antigen (PCNA) expressions were determined by immunohistochemical methods. Results: The number of MMP-2, MMP-9, NF-κB, PPAR-γ and IL-6 immunopositive cells increased in the diabetic rat liver as compared to control. The ghrelin treatment significantly reduced the numbers of MMP-2, MMP-9, NF-κB, PPAR-γ and IL-6 immunopositive cells in diabetic rat

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Diabetes mellitus triggers oxidative stress in the liver of alloxan-treated rats: a mechanism for diabetic chronic liver disease

Cited by 96 publications

References 32 publications

Proteomic and genomic studies of non-alcoholic fatty liver disease - clues in the pathogenesis

Proteomic and genomic studies of non-alcoholic fatty liver disease - clues in the pathogenesis

Protective effects of Quercetin and chronic moderate exercise (training) against oxidative stress in the liver tissue of streptozotocin-induced diabetic rats

The Effect of Ghrelin Treatment on Cell Survival and Inflammation in Type 2 Diabetic Rat Liver

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