Diabetes mellitus: Preventive and curative therapies with aqueous extract of Rytigynia senegalensis Blume (Rubiaceae) in Wistar rats

Maidadi, Barthelemy; Ntchapda, Fidèle; Miaffo, David; Mahamad, Abba Talba

doi:10.1016/j.jtcme.2023.03.001

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…The recovery of body weight in these rats could be explained by the ability of the extract to reduce hyperglycemia induced by STZ by stimulating insulin secretion; which would have contributed to this weight gain [ 35 ]. This result is similar to those obtained by Maidadi et al [ 36 ], who also showed an increase in body weight in diabetic rats treated with aqueous extract of Rytigynia senegalensis .…”

Section: Discussionsupporting

confidence: 92%

Antidiabetic activity of the aqueous extract of Erigeron floribundus leaves in streptozotocin-induced type 1 diabetes model in Wistar rats

Masky,

Adjia,

Miaffo

et al. 2024

Metabolism Open

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Section: Discussionsupporting

confidence: 92%

Antidiabetic activity of the aqueous extract of Erigeron floribundus leaves in streptozotocin-induced type 1 diabetes model in Wistar rats

Masky,

Adjia,

Miaffo

et al. 2024

Metabolism Open

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“…The disease is characterized by a high level glycemia. The over-production of ROS during diabetic status (hyperglycemia) constitutes the major causes of complications in diabetes including renal failure [3]. Diabetic nephropathy, associated with the end stage renal failure [4], has therefore attracted more than one strategy for the controls of diabetes [5].…”

Section: Introductionmentioning

confidence: 99%

Effect of Asparagus africanus (Asparaceae) Aqueous Extract on Renal Complications in High Fat Diet and Streptozotocin-Induced Type 2 Diabetes in Male albino Wistar Rats

Focham Evans,

Oumar,

Bashi Brenda

et al. 2024

Int J Diabetes Clin Res

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Background: Asparagus africanus has been claimed to possess antidiabetic activity in the ethnomedicinal literature. The present study was carried out to investigate the effect of aqueous extract of A. africanus (EAA) in control of renal complications in experimentally-induced type 2 diabetes mellitus in Wistar rats.Methods: Prior to the administration in rats, the acute toxicity effect of the plant was assessed in mice. Fat diet/ streptozotocin -induced type 2 diabetic Wistar rats treated orally with the EAA. Body weight was measured at specific intermissions during a treatment of 28 days. At the end of the treatment period, Kidney weight and serum and urine creatinine, albumin and urea were investigated. It was also evaluated the renal redox biomarkers along with histopathological examination of the kidney. Results:In diabetes rats, the aqueous extract of A. africanus significantly increased body weight. Additionally, aqueous extract of A. africanus also decreased the level of creatinine and blood urea nitrogen in serum with high level in urine. Moreover, aqueous extract of A. africanus significantly reduced the presence of albumin in urine. Furthermore, aqueous extract of A. africanus significantly increased the renal antioxidant biomarkers but reduced the oxidative inducing in low oxidative stress imbalance. The aqueous extract of A. africanus significantly reduced glomerulosclerosis and tubular atrophy. Conclusion:Aqueous extract of A. africanus possesses a promised potential to slow the dysfunction in renal function, oxidative imbalance and tissue damage in diabetic rats.

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Antidiabetic effect of the mixture of Cissus polyantha and Rytigynia senegalensis in high-fat diet and streptozocin-induced diabetic rats

Miaffo,

Maidadi,

Ezo'o

et al. 2024

Pharmacological Research - Modern Chinese Medicine

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Diabetes mellitus: Preventive and curative therapies with aqueous extract of Rytigynia senegalensis Blume (Rubiaceae) in Wistar rats

Cited by 3 publications

References 41 publications

Antidiabetic activity of the aqueous extract of Erigeron floribundus leaves in streptozotocin-induced type 1 diabetes model in Wistar rats

Antidiabetic activity of the aqueous extract of Erigeron floribundus leaves in streptozotocin-induced type 1 diabetes model in Wistar rats

Effect of Asparagus africanus (Asparaceae) Aqueous Extract on Renal Complications in High Fat Diet and Streptozotocin-Induced Type 2 Diabetes in Male albino Wistar Rats

Antidiabetic effect of the mixture of Cissus polyantha and Rytigynia senegalensis in high-fat diet and streptozocin-induced diabetic rats

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