Diabetes mellitus, other medical conditions and pancreatic cancer: a case‐control study

Lipworth, Loren; Bosetti, Cristina; Franceschi, Silvia; Talamini, Renato; Serraino, Diego; McLaughlin, Joseph K.; Vecchia, Carlo La; Negri, Eva

doi:10.1002/dmrr.1162

Cited by 29 publications

(20 citation statements)

References 53 publications

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“…Observational studies in humans have demonstrated the existence of relationships between several medical conditions, including cholecystitis [52], cholecystectomy [53], HBV infection [54] and ulcer gastrectomy [19], and an increased risk of pancreatic adenocarcinoma, but these findings have been somewhat contradictory. In our study, we observed a significant positive linear association between the risk of pancreatic adenocarcinoma and cholelithiasis (OR = 5.453).…”

Section: Discussionmentioning

confidence: 99%

“…In recent decades, accumulating evidence has identified long-standing, preexisting chronic pancreatitis, a rare inflammatory condition, as a strong risk factor for pancreatic cancer [12,19,45,46]. Case-control studies have estimated the increased risk of pancreatic cancer for patients with chronic pancreatitis to range from 2 to 16% [47].…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies have found that diabetes is a significant risk factor for total cancer incidence and mortality and for some site-specific cancers [18,19], notably breast and colorectal cancers and likely endometrial [18] and prostate cancers [18]. The relationship between diabetes and pancreatic adenocarcinoma remains controversial [20], but increasing epidemiological evidence supports the idea that long-standing diabetes has a role in the development of pancreatic adenocarcinoma [13,14].…”

Section: Discussionmentioning

confidence: 99%

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Metabolic Syndrome Components and Risk Factors for Pancreatic Adenocarcinoma: A Case-Control Study in China

Chen

et al. 2012

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Background: Metabolic syndrome is a complex collection of interrelated conditions. Recent data have shown that metabolic syndrome may play a role in several cancers. Pancreatic adenocarcinoma is the fourth most common cause of death from cancer in the United States and the fifth in Europe. Despite the increasing numbers of published studies, the etiology of pancreatic adenocarcinoma is incompletely defined. Therefore, this paper aims to evaluate the risk factors for pancreatic adenocarcinoma. Methods: This was a case-control study of pancreatic adenocarcinoma patients who were referred to the Peking Union Medical College Hospital. Controls were randomly selected from an existing database of healthy individuals at the Health Screening Center. Data on metabolic syndrome, pancreatic diseases, liver diseases, and a history of diabetes and history of hypertension were collected either by conducting a retrospective review of the patients’ records and health examination reports or by interview. Results: A history of smoking (OR = 2.981), diabetes (OR = 2.421), cholecystolithiasis (OR = 5.453), or chronic pancreatitis (OR = 28.264) as well as the levels of fasting blood glucose (OR = 4.241), total cholesterol (OR = 1.793), and apolipoprotein A (OR = 36.065) were significantly related to pancreatic adenocarcinoma. Conclusions: Cholelithiasis, chronic pancreatitis, and certain metabolic syndrome components are potential risk factors for the development of pancreatic adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Metabolic Syndrome Components and Risk Factors for Pancreatic Adenocarcinoma: A Case-Control Study in China

Chen

et al. 2012

Digestion

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“…To date, at least 13 epidemiologic studies have investigated the associations of cholecystectomy and/or gallstones with pancreatic cancer risk. The results obtained from these studies are overall conflicting (Lin and Kessler, 1981; Ekbom et al , 1996; Gullo et al , 1996; Chow et al , 1999; Coughlin et al , 2000; Silverman, 2001; Talamini et al , 2001; Ye et al , 2001; Lin et al , 2002; Schernhammer et al , 2002; Stolzenberg-Solomon et al , 2002; Hassan et al , 2007; Lipworth et al , 2011). Significantly increased risk associated with cholecystectomy and/or gallstones was observed in one case-control study (Silverman, 2001) and four cohort studies (Ekbom et al , 1996; Chow et al , 1999; Coughlin et al , 2000; Lin et al , 2002).…”

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confidence: 99%

Cholecystectomy, gallstones, tonsillectomy, and pancreatic cancer risk: a population-based case-control study in minnesota

et al. 2014

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Background:Associations between medical conditions and pancreatic cancer risk are controversial and are thus evaluated in a study conducted during 1994–1998 in Minnesota.Methods:Cases (n=215) were ascertained from hospitals in the metropolitan area of the Twin Cities and the Mayo Clinic. Controls (n=676) were randomly selected from the general population and frequency matched to cases by age and sex. The history of medical conditions was gathered with a questionnaire during in-person interviews. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using unconditional logistic regression.Results:After adjustment for confounders, subjects who had cholecystectomy or gallstones experienced a significantly higher risk of pancreatic cancer than those who did not (OR (95% CI): 2.11 (1.32–3.35) for cholecystectomy and 1.97 (1.23–3.12) for gallstones), whereas opposite results were observed for tonsillectomy (0.67 (0.48–0.94)). Increased risk associated with cholecystectomy was the greatest when it occurred ⩽2 years before the cancer diagnosis (5.93 (2.36–15.7)) but remained statistically significant when that interval was ⩾20 years (2.27 (1.16–4.32)).Conclusions:Cholecystectomy, gallstones, and tonsillectomy were associated with an altered risk of pancreatic cancer. Our study suggests that cholecystectomy increased risk but reverse causality may partially account for high risk associated with recent cholecystectomy.

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“…Some epidemiological studies have excluded the possibility that long-standing DM is a risk factor for PC [96][97][98][99][100][101][102][103][104][105][106][107][108] , whereas others have found the otherwise [109][110][111][112][113][114][115][116] .…”

Section: Diabetes Mellitus (Dm)mentioning

confidence: 99%

High risk factors of pancreatic carcinoma

Camara

Yin

Yang

et al. 2016

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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Over the past decades, cancer has become one of the toughest challenges for health professionals. The epidemiologists are increasingly directing their research efforts on various malignant tumor worldwide. Of note, incidence of cancers is on the rise more quickly in developed countries. Indeed, great endeavors have to be made in the control of the life-threatening disease. As we know it, pancreatic cancer (PC) is a malignant disease with the worst prognosis. While little is known about the etiology of the PC and measures to prevent the condition, so far, a number of risk factors have been identified. Genetic factors, pre-malignant lesions, predisposing diseases and exogenous factors have been found to be linked to PC. Genetic susceptibility was observed in 10% of PC cases, including inherited PC syndromes and familial PC. However, in the remaining 90%, their PC might be caused by genetic factors in combination with environmental factors. Nonetheless, the exact mechanism of the two kinds of factors, endogenous and exogenous, working together to cause PC remains poorly understood. The fact that most pancreatic neoplasms are diagnosed at an incurable stage of the disease highlights the need to identify risk factors and to understand their contribution to carcinogenesis. This article reviews the high risk factors contributing to the development of PC, to provide information for clinicians and epidemiologists.

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Diabetes mellitus, other medical conditions and pancreatic cancer: a case‐control study

Abstract: Diabetes is associated with heightened risk of pancreatic cancer. The association is significant for diabetes diagnosed up to 10 years before pancreatic cancer.

Cited by 29 publications

References 53 publications

Metabolic Syndrome Components and Risk Factors for Pancreatic Adenocarcinoma: A Case-Control Study in China

Metabolic Syndrome Components and Risk Factors for Pancreatic Adenocarcinoma: A Case-Control Study in China

Cholecystectomy, gallstones, tonsillectomy, and pancreatic cancer risk: a population-based case-control study in minnesota

High risk factors of pancreatic carcinoma

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