Diabetes mellitus is not a risk factor for osteoarthritis

Abstract

BackgroundAssociation between diabetes mellitus (DM) and risk of osteoarthritis (OA) can be confounded by body mass index (BMI), a strong risk factor for both conditions. We evaluate the association between DM or hyperglycaemia with OA using systematic review and meta-analysis.MethodsWe searched PubMed and Web of Science databases in English for studies that gave information on the association between DM and OA. Two meta-analysis models were conducted to address: (1) risk of DM comparing subjects with and without OA and (2) risk of OA comparing subjects with and without DM. As far as available, risk estimates that adjusted for BMI were used.Results31 studies with a pooled population size of 295 100 subjects were reviewed. 16 and 15 studies reported positive associations and null/ negative associations between DM and OA. 68.8% of positive studies had adjusted for BMI, compared with 93.3% of null/negative studies. In meta-analysis model 1, there was an increase prevalence of DM in subjects with OA compared with those without (OR 1.56, 95% CI 1.28 to 1.89). In meta-analysis model 2, there was no increased risk of OA (OR 1.14, 95% CI 0.98 to 1.33) in subjects with DM compared with those without, regardless of gender and OA sites. Comparing subjects with DM to those without, an increased risk of OA was noted in cross-sectional studies, but not in case-control and prospective cohort studies.ConclusionsThis meta-analysis does not support DM as an independent risk factor for OA. BMI was probably the most important confounding factor.

Investigating the Association of Metabolic Biomarkers With Knee Cartilage Composition and Structural Abnormalities Using MRI: A Pilot Study

“…While some studies have reported associations of diabetes and dyslipidemia with knee OA, 8,9,12,34,35 others have found no associations. 36,37 Two meta-analyses reported associations of diabetes with OA even when controlling for BMI 8,9 while a more recent meta-analysis found no association. 36 In a meta-analysis of 48 studies, Baudart et al .…”

“…36,37 Two meta-analyses reported associations of diabetes with OA even when controlling for BMI 8,9 while a more recent meta-analysis found no association. 36 In a meta-analysis of 48 studies, Baudart et al . demonstrated an association of dyslipidemia with OA.…”

Metabolic syndrome and the incidence of knee osteoarthritis: A meta-analysis of prospective cohort studies

“…Moreover, a recent meta-analysis with nine studies showed that even though pooled results of case-control and cross-sectional studies suggested a strong relationship between dyslipidemia and KOA, this relationship was not validated by meta-analysis of only cohort studies [ 34 ]. Similarly, an updated meta-analysis with 31 studies failed to show that diabetes is an independent risk factor for KOA, after incorporating BMI into the analysis [ 35 ]. Taken together, these results indicated that MetS was not an independent risk factor for overall KOA in general population after adjustment of confounding factors including BMI.…”

Clinical features and risk factors of diabetes-associated osteoarthritis

“…ЦД і остеоартрит (ОА) є поширеними захворюваннями, пов'язаними зі спільними для них факторами ризику й ускладненнями. Хоча дуже часто можна зустріти суперечливі висновки стосовно ролі різних факторів ризику в розвитку ураження суглобів у хворих на ЦД [6]. Крім того, основні дослідження стосувалися колінних і кульшових суглобів [1,9,10], рідше -суглобів кисті [11,12].…”

“…Інші фактори, такі як вік, етнічна приналежність, стать, індекс маси тіла (ІМТ), артеріальна гіпертензія, нейропатія і дисліпідемія, які впливають як на ЦД, так і на ОА, не були повністю вивчені [13,14]. Слід відзначити, що донедавна ЦД не вважався чинником ризику розвитку ОА, якщо не зважати на роль ЦД у розвитку артропатій, які об'єднують не лише ОА, але й інші форми ураження суглобів (тугорухливість суглобів, артрити тощо) [6,15]. Роль ожиріння в розвитку ОА не викликала сумнівів, при цьому відзначалося саме підвищення навантаження на несучі суглоби, зокрема колінні; при цьому зв'язку надмірної маси тіла із розвитком ОА не виявляли [16,17].…”