Diabetes mellitus is associated with an increased expression of resistin in human pancreatic islet cells

Al-Salam, Suhail; Rashed, Hameed; Adeghate, Ernest

doi:10.4161/isl.3.5.16427

Cited by 20 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It should be noted that the islets and b-cells used in these studies were of mouse origin, and the findings have not as yet been repeated in human islets. What has been shown in human islets is that resistin is actually expressed within them and that its expression is up-regulated in type 2 diabetes (Minn et al 2003, Al-Salam et al 2011, so although the role of resistin in regulating human pancreatic b-cell mass/function as an adipokine may be yet to be demonstrated, it seems that it may nevertheless have an important role as an intracellular protein.…”

Section: Resistinmentioning

confidence: 99%

The role of adipokines in β-cell failure of type 2 diabetes

Dunmore

Brown

2012

Journal of Endocrinology

178

138

View full text Add to dashboard Cite

Abstractb-Cell failure coupled with insulin resistance is a key factor in the development of type 2 diabetes. Changes in circulating levels of adipokines, factors released from adipose tissue, form a significant link between excessive adiposity in obesity and both aforementioned factors. In this review, we consider the published evidence for the role of individual adipokines on the function, proliferation, death and failure of b-cells, focusing on those reported to have the most significant effects (leptin, adiponectin, tumour necrosis factor a, resistin, visfatin, dipeptidyl peptidase IV and apelin). It is apparent that some adipokines have beneficial effects whereas others have detrimental properties; the overall contribution to b-cell failure of changed concentrations of adipokines in the blood of obese pre-diabetic subjects will be highly dependent on the balance between these effects and the interactions between the adipokines, which act on the b-cell via a number of intersecting intracellular signalling pathways. We emphasise the importance, and comparative dearth, of studies into the combined effects of adipokines on b-cells.

show abstract

Section: Resistinmentioning

confidence: 99%

The role of adipokines in β-cell failure of type 2 diabetes

Dunmore

Brown

2012

Journal of Endocrinology

178

138

View full text Add to dashboard Cite

show abstract

“…While, Al-Salam showed that resistin is co-localizated with insulin in human islets 12 . We assume that pancreatic resistin may lead to paracrine and autocrine regulations within the islets.…”

mentioning

confidence: 99%

Resistin is produced by rat pancreatic islets and regulates insulin and glucagon in vitro secretion

Sassek

Pruszyńska‐Oszmałek

Kołodziejski

et al. 2016

Islets

View full text Add to dashboard Cite

Resistin participates in the regulation of energy homeostasis, insulin resistance, and inflammation. The potential expression in pancreas, and modulation of the endocrine pancreas secretion by resistin is not well characterized, therefore, we examined it on several levels.We examined the localization of resistin in rat pancreatic islets by immunohistochemistry and immunofluorescence, and the potential presence of resistin mRNA by RT-PCR and protein by Western Blot in these structures. In addition, we studied the regulation of insulin and glucagon secretion by resistin in pancreatic INS-1E b-and InR-G9 a-cell lines as well as isolated rat pancreatic islets.We identified resistin immunoreactivity in the periphery of rat pancreatic islets and confirmed the expression of resistin at mRNA and protein level. Obtained data indicated that resistin is co-localized with glucagon in pancreatic a-cells. In addition, we found that in vitro resistin decreased insulin secretion from INS-1E cells and pancreatic islets at normal (6 mM) and high (24 mM) glucose concentrations, and also decreased glucagon secretion from G9 cells and pancreatic islets at 1 mM, whereas a stimulation of glucagon secretion was observed at 6 mM glucose. Our results suggest that resistin can modulate the secretion of insulin and glucagon from clonal b or a cells, and from pancreatic islets.

show abstract

“…Resistin is a cysteine-rich and unique signalling adipokine molecule that is released by adipocytes and macrophages (23). In addition to adipose tissue, resistin expression and its co-localization with insulin and glucagon in pancreatic cells was also identified via immunofluorescence technique by Suhail et al (24). They showed that many of pancreatic cells expressing resistin increased significantly after the onset of T2DM.…”

Section: Discussionmentioning

confidence: 99%

Untitled

et al. 2016

View full text Add to dashboard Cite

The current study was designed to investigate the changes of the resistin, aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels of diabetic rats after treatment with Morus alba leaves flavonoid extract (MLE) and Morus alba leaves powder (MLP). Thirty male wistar rats in five groups including control and diabetic groups were included. Diabetic groups consisted of diabetic control, sham and treated group with MLE and MLP. Type 2 diabetes was induced in rats by administration of streptozotocin (STZ) and nicotinamide. The serum concentrations of resistin and insulin in the study groups were identified by ELISA. ALT and AST activities were assayed by spectrophotometer. For the first time, it was shown that the uptake of MLE and MLP by diabetic rats could significantly decrease the serum fasting blood sugar (FBS), resistin levels and enzymes activity of ALT and AST and increases the concentration of serum insulin significantly (P<0.05). in comparison with the sham group and diabetic control. The results showed that there was no significant difference between the anti-diabetic and inflammatory properties of MLE and MLP. In this study, the possible protective effect of MLE and MLP administration was evaluated against destructive effect of STZ on liver and pancreas function in diabetic rats. The results showed that these effects may play an important role in the regulating of adipokines secretion such as resistin and insulin secretion which are involved in the control of diabetes and obesity. MLE and MLP treatment could be useful agents in combination with other therapies in diabetes improvement.

show abstract

Diabetes mellitus is associated with an increased expression of resistin in human pancreatic islet cells

Cited by 20 publications

References 17 publications

The role of adipokines in β-cell failure of type 2 diabetes

The role of adipokines in β-cell failure of type 2 diabetes

Resistin is produced by rat pancreatic islets and regulates insulin and glucagon in vitro secretion

Untitled

Contact Info

Product

Resources

About