Diabetes mellitus in older men

Abstract

Most persons with diabetes mellitus are over the age of 60 years. Males develop diabetes more commonly than females. Older diabetics tend to have both impaired insulin release as well as insulin resistance. In older persons diabetes mellitus is associated with decreased functional status and cognitive dysfunction. In general, older persons with diabetes are inclined to be underdiagnosed and undertreated. Managing diabetes in older persons requires special considerations because of their differences in pathophysiology of diabetes and strong association with functional, cognitive impairments and comorbidities. The use of strict therapeutic diets is not recommended in older persons. Treatment of hypertension and hyperglycemia can improve outcomes in older persons. The interdisciplinary team approach is important for care of older diabetic persons.

The prevalence of prediabetes in population of Polish men with late-onset hypogonadism

“…Low testosterone is also an independent risk factor for high-fasting plasma glucose [2] leading to an increased prevalence of impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) in men [3]. Approximately 7% of the world population is estimated to have IGT.…”

Traditional Cardiovascular Risk Factors and Severity of Angiographic Coronary Artery Disease in the Elderly

“…[5][6][7][8][9][10][11][12] It is important to recognize that compared with younger adults, CVRF assessment in the elderly is perhaps not as straightforward but rather poses a formidable challenge for three apparent reasons: First, traditional risk factors in themselves are independently associated with advancing age. [13][14][15][16] Second, age itself is a risk factor for cardiovascular disease and a confounding factor in risk scoring systems; thus, measures of risk derived from younger populations may not be generalizable to older patients. 17,18 Third, the elderly have historically been underrepresented in large epidemiologic studies evaluating CAD risk.…”

Should frailty be treated with testosterone?

“…These result in atrophy of the fast muscle fibres, an increase in hybrid fibres and a decrease in satellite cells [21]. Insulin resistance that occurs with aging coupled with disease results in an increase in fat accumulation in the muscles [22]. This leads to the development of the 'fat frail' or 'obese sarcopenic' syndrome which leads to disability and increased mortality [23][24][25].…”