“…A-T patients also exhibit poor weight gain, a progressive decrease in their BMI, and progressive dystrophy (Schubert et al, 2005). In addition to A-T patients, A-T carriers, who comprise an estimated 0.05%-0.1% of the normal population, suffer an increased risk of ischemic heart disease (Su and Swift, 2000) and diabetes (Morrell et al, 1986). As in A-T patients, glucose intolerance has been reported in Atm À/À , Atm +/À ApoE À/À , and Atm À/À ApoE À/À mice (Miles et al, 2007;Schneider et al, 2006); the Atm +/À ApoE À/À mouse model generates a state of insulin resistance similar to that observed in type 2 diabetes.…”