Diabetes mellitus, frailty and prognosis in very elderly patients with acute coronary syndromes

Gual, Miquel Mir; Formiga, Francesç; Arizá-Solé, Albert; López-Palop, Ramón; Sanchís, Juan; Marı́n, Francisco; Vidán, María Teresa; Martínez‐Sellés, Manuel; Sionís, Alessandro; Sánchez‐Salado, José Carlos; Lorente, Victòria; Díez‐Villanueva, Pablo; Vives‐Borrás, Miquel; Cordero, Alberto; Bueno, Héctor; Alegre, Oriol; Abu‐Assi, Emad; Cequier, Ángel; investigators, Longevo-Sca registry

doi:10.1007/s40520-018-01118-x

Cited by 13 publications

(22 citation statements)

References 38 publications

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“…Regarding epidemiological parameters, this review included 31 articles published between 2009 and 2019 that analysed the prevalence of CVD overall or a type of CVD in patients with T2DM in Spain [ 15 , 16 , 19 , 20 , 23 – 25 , 28 – 35 , 37 , 42 , 43 , 45 , 52 , 54 – 57 , 59 – 63 , 65 , 66 ], 20 articles that analysed incidence [ 15 , 21 – 23 , 27 , 36 , 38 – 41 , 44 , 46 , 48 – 51 , 53 , 56 , 58 , 64 ], and 18 articles that analysed mortality [ 16 , 18 , 21 , 22 , 25 , 27 , 30 , 31 , 38 – 41 , 44 , 46 , 56 , 57 , 60 , 66 ].…”

Section: Resultsmentioning

confidence: 99%

“…The literature review identified several studies that reported the prevalence of CVD or a type of CVD in patients with T2DM in special populations, such as those of a predetermined age range or with additional comorbidities (Table 2 ). These studies focused on elderly patients [ 29 , 31 , 35 , 61 ], patients with HF [ 30 , 31 , 33 , 35 ] and patients with kidney disease [ 59 , 60 ]. Several studies reported age as one of the main risks for CVD in patients with T2DM.…”

Section: Resultsmentioning

confidence: 99%

“…Information on the occurrence of subsequent CV events in patients with T2DM was specifically mentioned in 7 of the 20 studies reporting incidence [ 22 , 23 , 30 , 31 , 33 , 35 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

“…Two studies studied subsequent CV events in elderly patients with T2DM [ 31 , 35 ]. A study of 240 patients aged ≥ 75 years first admitted for acute HF reported that 28.8% had a previous diagnosis of CHD and 19.2% had a previous stroke [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

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Epidemiology and Economic Burden of Cardiovascular Disease in Patients with Type 2 Diabetes Mellitus in Spain: A Systematic Review

et al. 2021

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Introduction: Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in people with type 2 diabetes mellitus (T2DM). The objectives of this systematic literature review were to identify and synthesize published data describing the epidemiology and mortality of CVD in the T2DM population and the associated economic burden. Methods: We conducted a systematic review searching the PubMed and MEDES databases from 2009 to 2019 using predefined selection criteria. Peer-reviewed observational studies reporting primary or secondary data on CVD prevalence, incidence, mortality, resource use and costs in patients with T2DM in Spain, written in English and Spanish, were included. Data were tabulated and summarized descriptively. Results: Of 706 articles identified, 52 were included in the review. Most studies were based on data from hospital discharge databases and registries. The reported prevalence of CVD among patients with T2DM ranged from 6.9 to 40.8%. The prevalence of coronary heart disease ranged from 4.7 to 37%, stroke from 3.5 to 19.6%, peripheral artery disease from 2.5 to 13.0%, and heart failure from 4.3 to 20.1%. Inhospital CVD mortality rates ranged from 5.6 to 10.8%. Direct costs due to CVD in hospitalized patients with T2DM were increased ([ 50%) compared with patients without CVD. No studies analysed indirect costs of CVD in patients with T2DM. Conclusions: The burden of CVD among patients with T2DM, combined with the elevated costs of care, highlights the importance of early prevention as part of integrated management of the disease to improve clinical and economic outcomes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Information on the occurrence of subsequent CV events in patients with T2DM was specifically mentioned in 7 of the 20 studies reporting incidence [ 22 , 23 , 30 , 31 , 33 , 35 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Epidemiology and Economic Burden of Cardiovascular Disease in Patients with Type 2 Diabetes Mellitus in Spain: A Systematic Review

et al. 2021

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“…Diabetes mellitus has become a serious problem, especially in the elderly population, due to increasing prevalence and more frequent complications 44,45…”

Section: Discussionmentioning

confidence: 99%

<p>Photosensitivity reactions in the elderly population: questionnaire-based survey and literature review</p>

Korzeniowska¹,

Cieślewicz²,

Chmara³

et al. 2019

TCRM

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PurposeOlder people are at risk of developing adverse drug reactions, including photosensitivity reactions. Therefore, the aim of the study was to assess the use of potentially photosensitizing medications and photoprotection in the elderly population.Patients and methodsThree hundred and fifty-six respondents (223 [63%] women and 133 [37%] men) aged ≥65 years filled in the original questionnaire concerning photosensitivity reactions to drugs. The diagnosis of drug-induced photosensitivity was based on medical history and clinical examination.Results and conclusionWe found that drugs potentially causing phototoxic/photoallergic reactions comprised more than one fifth of all drugs used by the participants. The most numerous group was patients treated with 3–5 drugs potentially causing phototoxic/photoallergic reactions simultaneously. Of all drugs, ketoprofen was found to cause the highest number of photosensitivity reactions. Cutaneous adverse reactions were also observed for hydrochlorothiazide, atorvastatin, simvastatin, telmisartan, and metformin. Moreover, it was found that the incidence of photosensitivity reactions can be significantly reduced by using proper photoprotection.

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What are the consequences of over and undertreatment of type 2 diabetes mellitus in a frail population? A systematic review

O'Neil,

Todd,

Pearce

et al. 2024

Endocrino Diabet & Metabol

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AimsThis review aims to identify the evidence base for the consequences of over and undertreatment of type 2 diabetes mellitus in a frail population.MethodIn this systematic review, we searched MEDLINE, Embase, PubMed, CINAHL and the Cochrane Library for studies from January 2001 to 15th August 2022. We included a variety of study types that assessed and reported frailty including patients ≥18 years old. Studies included those that reported the prevalence of over or undertreatment of diabetes mellitus in a frail population and those examining outcomes related to glucose control in frail older people living with diabetes. Data were extracted using a bespoke extraction table using a narrative synthesis approach.ResultsA total of 4114 articles were identified with 112 meeting inclusion criteria. These included 15,130 participants across the 11 studies with sample sizes ranging from 101 to 11,140. Several areas were identified in the included studies where under or overtreatment of diabetes impacted outcomes for patients. These included hospital admissions, readmissions, length of stay, falls, mortality, cognitive impairment and cardiovascular disease outcomes.ConclusionThe results showed that there was a high heterogeneity of outcomes between the studies and that many examined small numbers of participants. In this review, both over and undertreatment were shown to increase adverse outcomes in frail older people. Further research around optimal glycaemic control for frail older people living with diabetes is required with the aim to identify ideal target ranges and produce practical clinical guidelines to promote attainment of these.

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Diabetes mellitus, frailty and prognosis in very elderly patients with acute coronary syndromes

Cited by 13 publications

References 38 publications

Epidemiology and Economic Burden of Cardiovascular Disease in Patients with Type 2 Diabetes Mellitus in Spain: A Systematic Review

Epidemiology and Economic Burden of Cardiovascular Disease in Patients with Type 2 Diabetes Mellitus in Spain: A Systematic Review

<p>Photosensitivity reactions in the elderly population: questionnaire-based survey and literature review</p>

What are the consequences of over and undertreatment of type 2 diabetes mellitus in a frail population? A systematic review

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