Diabetes mellitus correlates with increased risk of pancreatic cancer: A population‐based cohort study in Taiwan

Liao, Kuan‐Fu; Lai, Shih‐Wei; Li, Chia‐Ing; Chen, Wen‐Chi

doi:10.1111/j.1440-1746.2011.06938.x

Cited by 133 publications

(106 citation statements)

References 18 publications

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“…2). A recent cohort study in Taiwan showed that in addition to age, CP (HRZ19.40), gallstones (HRZ2.56), and hepatitis C infection (HRZ3.08) were significant factors predicting PC; patients with concurrent DM and CP had a dramatically elevated risk of developing PC (HRZ33.52), compared with subjects without these comorbidities (Liao et al 2012). …”

Section: Diabetes (And Obesity) As a Cause Of Pcmentioning

confidence: 99%

Diabetes and pancreatic cancer

Cui¹,

Andersen²

2012

Endocrine-Related Cancer

128

102

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Epidemiological studies clearly indicate that the risk of pancreatic cancer (PC) is increased in diabetic patients, but most studies focus on overall diabetes or type 2 diabetes mellitus (T2DM), and there are few studies on the risks of type 1 and type 3c (secondary) diabetes. Possible mechanisms for increased cancer risk in diabetes include cellular proliferative effects of hyperglycemia, hyperinsulinemia, and abnormalities in insulin/IGF receptor pathways. Recently, insulin and insulin secretagogues have been observed to increase the PC risk, while metformin treatment reduces the cancer risk in diabetic subjects. In addition, anticancer drugs used to treat PC may either cause diabetes or worsen coexisting diabetes. T3cDM has emerged as a major subset of diabetes and may have the highest risk of pancreatic carcinoma especially in patients with chronic pancreatitis. T3cDM is also a consequence of PC in at least 30% of patients. Distinguishing T3cDM from the more prevalent T2DM among new-onset diabetic patients can be aided by an assessment of clinical features and confirmed by finding a deficiency in postprandial pancreatic polypeptide release. In conclusion, diabetes and PC have a complex relationship that requires more clinical attention. The risk of developing PC can be reduced by aggressive prevention and treatment of T2DM and obesity and the prompt diagnosis of T3cDM may allow detection of a tumor at a potentially curable stage.

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Section: Diabetes (And Obesity) As a Cause Of Pcmentioning

confidence: 99%

Diabetes and pancreatic cancer

Cui¹,

Andersen²

2012

Endocrine-Related Cancer

128

102

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show abstract

“…Table 1A summarizes epidemiological studies that show pancreatic cancer risk and cancer mortality associated with metformin use while Table 1B presents observational studies and clinical trials on overall cancer risk and mortality in relation to metformin use. While some studies show a reduction in pancreatic cancer [35][36][37][38][39] and overall cancer risk [37,[39][40][41][42][43][44][45] among diabetic metformin users, there are also studies that report no significant difference in cancer risk among diabetics who take metformin compared to patients who take other anti-diabetic treatments [36,[46][47][48][49][50][51]. These conflicting results may be explained by differences in the study population, the confounding factors accounted for during statistical analysis and the selected study design (e.g., cohort versus case-control).…”

Section: Chemopreventive Properties Of Metforminmentioning

confidence: 60%

Metformin and Pancreatic Cancer Metabolism

Cantoria¹,

Hitendra²,

Boros³

et al. 2014

Pancreatic Cancer - Insights Into Molecular Mechanisms and Novel Approaches to Early Detection and Treatment

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“…Whether the coexistence of CP with DM increases the overall risk of PC is unclear. In a population based cohort study by Liao et al [20], risk of PC in patients with CP and DM combined was higher than that for patients with CP alone (HR= 33.52 vs HR=19.4). This finding is confounded by the fact that diabetes could be a manifestation of PC in CP, rather than a risk factor.…”

Section: Pathogenesis Of Pancreatic Cancer In Chronic Pancreatitismentioning

confidence: 91%

Pancreatic Cancer in Chronic Pancreatitis

Dhar

Kalghatgi

Saraf

2015

Indian J Surg Oncol

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Data exists to indicate a definite association between chronic pancreatitis and pancreatic cancer. The strength of this association varies between various causes of pancreatitis, with hereditary and tropical pancreatitis more likely to result in malignancy. Pathogenesis may involve genetic factors, diabetes, smoking and alcohol consumption. Clinically a significant overlap exists between the two conditions, with histology difficult to obtain and interpret in this setting. Biomarkers like CA19-9 and others may be useful, as is a variety of newer imaging modalities. Treatment needs to be individualised as surgery offers the only chance of cure, albeit in but a few.

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Diabetes mellitus correlates with increased risk of pancreatic cancer: A population‐based cohort study in Taiwan

Cited by 133 publications

References 18 publications

Diabetes and pancreatic cancer

Diabetes and pancreatic cancer

Metformin and Pancreatic Cancer Metabolism

Pancreatic Cancer in Chronic Pancreatitis

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