Diabetes Mellitus as Cancer Risk: A 14-year, Cross-Sectional Analysis

Saewai, Chutchawan; Fumaneeshoat, Orapan; Thongsuksai, Paramee; Ingviya, Thammasin

doi:10.1080/01635581.2023.2205054

Cited by 5 publications

(5 citation statements)

References 39 publications

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“…Previous studies have indicated that up to 16% of individuals diagnosed with GBM have T2DM, aligning with our findings that T2DM increases the risk of GBM 25 , 26 . These results are consistent with research linking T2DM to an increased cancer risk, though associations specifically with GBM have been less explored 5 , 27 . Our study contributes a comprehensive analysis of the correlation between T2DM and an elevated risk for GBM and constitutes a significant advancement over previous studies 28 .…”

Section: Discussionsupporting

confidence: 89%

Causal relationship between type 2 diabetes and glioblastoma: bidirectional Mendelian randomization analysis

Chen,

Zhang,

Zhang

2024

Sci Rep

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As the prevalence of Type 2 Diabetes Mellitus (T2DM) and Glioblastoma (GBM) rises globally, the relationship between T2DM and GBM remains controversial. This study aims to investigate whether genetically predicted T2DM is causally associated with GBM. We performed bidirectional Mendelian randomization (MR) analysis using data from genome-wide studies on T2DM (N = 62,892) and GBM (N = 218,792) in European populations. The results of the inverse-variance weighted (IVW) approach served as the primary outcomes. We applied Cochran’s Q test and MR-Egger regression for heterogeneity assessment. Leave-one-out analysis was used to evaluate whether any single SNP significantly influenced the observed effect. Our findings reveal a significant causal association between T2DM and an increased risk of GBM (OR [95% CI] 1.70 [1.09, 2.65], P = 0.019). Conversely, the reverse association between T2DM and GBM was insignificant (OR [95% CI] 1.00 [0.99, 1.01], P = 0.408) (P > 0.40). Furthermore, the results from Cochran’s Q-test and funnel plots in the MR-Egger method indicated no evidence of pleiotropy between the SNPs and GBM. Additionally, we mapped causal SNPs to genes and identified 10 genes, including MACF1, C1orf185, PTGFRN, NOTCH2, ABCB10, GCKR, THADA, RBMS1, SPHKAP, and PPARG, located on chromosomes 1, 2, and 3. These genes are involved in key biological processes such as the BMP signaling pathway and various metabolic pathways relevant to both conditions. This study provides robust evidence of a significant causal relationship between T2DM and an increased risk of GBM. The identified SNP-mapped genes highlight potential biological mechanisms underlying this association.

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Section: Discussionsupporting

confidence: 89%

Causal relationship between type 2 diabetes and glioblastoma: bidirectional Mendelian randomization analysis

Chen,

Zhang,

Zhang

2024

Sci Rep

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“…Epidemiological investigation showed that the risk of cancer (including liver cancer, pancreatic cancer, colorectal cancer, breast cancer and endometrial cancer) of diabetes patients would increase signi cantly, and the risk of cancer mortality would also increase signi cantly [32]. In a 14 year cross-sectional study, Chutchawan Saewai et al found that the long-term risk of prostate cancer in diabetes patients will signi cantly increase [33]. Other studies have also proved that obesity and diabetes were independent risk factors for prostate cancer, and might have synergistic effects, further increasing the risk of invasive prostate cancer [34][35].…”

Section: Discussionmentioning

confidence: 99%

DM and PCa risk: a mendelian randomization analysis

Yuan,

Jiang,

2023

Preprint

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Introduction: Some studies have shown that there is a certain relationship between diabetes mellitus (DM) and prostate cancer (PCa), but the specific relationship is still inconclusive. This study will investigate the potential relationship from the perspective of Mendelian randomization (MR) research. Method: We downloaded relevant data of "diabetes" and "prostate cancer" from the IEU OpenGWAS project database, performing three different methods to conduct MR analysis, and carried out sensitivity analysis for verification. Results: The results indicated that DM was an independent risk factor for PCa. The OR values obtained through the inverse variance weighted (IVW) method in this study was: OR = 1.018 (95% CI, 1.004 to 1.032), P = 0.014. Conclusion: Through our research, we found that DM could increase the incidence rate of PCa.

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“… Retrieval time before July 2016 Women:RR =1.11 (95% CI:1.06–1.17) Men:RR= 1.14 (95% CI:1.00–1.30) Dong et al 19 Lithuania Canada China Finland Korea Denmark USA, Israel Different types of diabetes mellitus and risk of thyroid cancer A meta-analysis of cohort studies The sample size of the included studies was greater than 300,000. The mean follow-up time ranged from 3.0 to 20.8 years Women: HR = 1.36 (95% CI, 1.22–1.52) Men: HR = 1.26 (95% CI, 1.12–1.41) Saewai et al 20 USA Diabetes Mellitus as Cancer Risk A Cross-Sectional Analysis 29,314 diabetes patients. Diagnosed diabetes in 2004–2018 Follow-up to diagnosed cancer Women: SIR = 3.51 (95% CI: 3.12–3.96) Men: SIR = 2.99 (95% CI:2.65–3.39) Hu et al 21 USA Incident Type 2 Diabetes Duration and Cancer Risk A Prospective Study in Two US Cohorts 113 429 women,45604men.…”

Section: Diabetes As a Risk Factor Of Thyroid Cancermentioning

confidence: 99%

“… 19 A 14-year cross-sectional study found that diabetes increases the risk of thyroid cancer in women. 20 A prospective study on the risk of new-onset type 2 diabetes and cancer found that the risk of thyroid cancer in patients with type 2 diabetes increased significantly. 21 Many studies have demonstrated an increased risk of thyroid cancer in patients with diabetes; however, prospective studies with large sample sizes are still needed to verify the correlation between diabetes and thyroid cancer risk and to explore the potential mechanism underlying their relationship.…”

Section: Diabetes As a Risk Factor Of Thyroid Cancermentioning

confidence: 99%

Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention

Wu,

Zhang,

Zou

et al. 2024

DMSO

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The incidences of thyroid cancer and diabetes are rapidly increasing worldwide. The relationship between thyroid cancer and diabetes is a popular topic in medicine. Increasing evidence has shown that diabetes increases the risk of thyroid cancer to a certain extent. This mechanism may be related to genetic factors, abnormal thyroid-stimulating hormone secretion, oxidative stress injury, hyperinsulinemia, elevated insulin-like growth factor-1 levels, abnormal secretion of adipocytokines, and increased secretion of inflammatory factors and chemokines. This article reviews the latest research progress on the relationship between thyroid cancer and diabetes, including the association between diabetes and the risk of developing thyroid cancer, its underlying mechanisms, and potential anti-thyroid cancer effects of hypoglycemic drugs. It providing novel strategies for the prevention, treatment, and improving the prognosis of thyroid cancer.

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Diabetes Mellitus as Cancer Risk: A 14-year, Cross-Sectional Analysis

Cited by 5 publications

References 39 publications

Causal relationship between type 2 diabetes and glioblastoma: bidirectional Mendelian randomization analysis

Causal relationship between type 2 diabetes and glioblastoma: bidirectional Mendelian randomization analysis

DM and PCa risk: a mendelian randomization analysis

Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention

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