“…Its development is usually time-extended, attends to the graft (material, methods of preparation, viability, correctness of implantation, tissue fatigue), patient (age, actual and at operation, history of rheumatic disease, infections, presence of immunologic complexes, genetics, diabetes, arterial hypertension, atherosclerosis, metabolic and hormonal function, renal insufficiency, aortic root distension, diseases of connective tissue, the influence of drugs and their effectiveness), environmental factors, etc. [3,6,46,47,55,67,78,85,86]. An advanced phase of biologic valves degeneration is mineralization, interrelated with calcium phosphates It starts in the cytosol and extracellular matrix, where occur centers of mineralization, as "hole zones" in the structure of collagen, areas of damage of collagen and elastin fibers, apoptotic cells, fibrinogen debris; where may be bound ions and substances.…”