Diabetes Mellitus as a Risk Factor for Functional and Cognitive Decline in Very Old People: The Octabaix Study

Formiga, Francesç; Ferrer, Assumpta; Padrós, Glòria; Corbella, Xavier; Cos, Lourdes; Sinclair, Alan J.; Rodríguez‐Mañas, Leocadio

doi:10.1016/j.jamda.2014.07.019

Cited by 40 publications

(22 citation statements)

References 18 publications

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“…The study compared the incidence of functional or cognitive impairment and its associated factors in diabetic and nondiabetic participants. Those with diabetes were more than twice as likely to develop a new disability over 2 years compared with their nondiabetic counterparts, indicating that diabetes increases the risk of incident disability, which is evident in only a short period of follow-up [13]. This greater rate of functional impairment is associated with increased disability, morbidity, mortality and institutionalization [14].…”

Section: Diabetes Mellitusmentioning

confidence: 99%

The emergence of frailty and sarcopaenia in diabetes mellitus: description of inter-relationships and clinical importance

Sinclair¹,

Sinclair

Bellary

et al. 2016

Cardiovascular Endocrinology

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Diabetes mellitus is a highly prevalent chronic disease, with an associated heavy personal and public health burden of disability, morbidity and mortality. The focus of care for older patients with diabetes is prevention of functional decline, with early intervention rather than attempting to recover function later. Diabetes doubles the risk of frailty. An important contributor towards physical frailty is sarcopaenia, which manifests as an age-related loss of skeletal muscle volume and power. Frailty is not an inevitable consequence of the ageing process; it is a dynamic and potentially reversible condition that highlights the importance of early recognition and intervention. In this review, we examine the evidence for linking diabetes to frailty and sarcopaenia and how the emergence of these conditions should lead to changes in clinician behaviour in terms of assessment of function and goal setting. High-quality, focused research in this area is now mandatory. Cardiovasc Endocrinol 5:40-50

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Section: Diabetes Mellitusmentioning

confidence: 99%

The emergence of frailty and sarcopaenia in diabetes mellitus: description of inter-relationships and clinical importance

Sinclair¹,

Sinclair

Bellary

et al. 2016

Cardiovascular Endocrinology

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“…1,2 Prevalence of diabetes has been rising rapidly across all age, sex, and racial/ethnic groups for several decades. There is strong evidence that diabetes is associated with cognitive impairment and dementia, [3][4][5][6][7][8][9][10][11][12] increases the risk for mild cognitive impairment (MCI) and Alzheimer's disease (AD), 13,14 and increases the risk for vascular dementia. 8,[15][16][17][18] The nature of cognitive deficit in diabetes and its patterns of cognitive deficit and the likelihood of further decline however, are not well characterized.…”

mentioning

confidence: 99%

Longitudinal Cognitive Profiles in Diabetes: Results From the National Alzheimer's Coordinating Center's Uniform Data

Sano

Zhu

Grossman

et al. 2017

J American Geriatrics Society

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Background Diabetes is a risk factor for the development of cognitive impairment and possibly for accelerated progression to Alzheimer disease (AD) and other dementias, though the trajectory of cognitive decline in general and in specfic cognitive domains by diabetes is unclear. Methods Using the National Alzheimer's Coordinating Center Uniform Data Set (NACC-UDS) to identify cohorts of elders with normal cognition (N=7,663) and Mild Cognitive Impairment (MCI, N=4,114), we compared overall cognitive composite and domain specific subscores and their progression over time between diabetic and non-diabetic subjects. Results Diabetes was more common among those with MCI (14.7%) than among subjects who were cognitively normal (11.7%). In subjects who were cognitively normal, baseline cognitive composite scores, attention, and executive function subscores were lower in diabetics than non-diabetics (by 0.098, 0.066, and 0.015 points, respectively). Over time, cognitive composite score showed subtle worsening in non-diabetics (0.025 points every 6 months), with an additional worsening of 0.01 points every 6 months in diabetics compared to non-diabetics. In the MCI groups, baseline cognitive composite as well as attention and executive domain subscores were lower in diabetics than non-diabetics (by 0.078, 0.092, and 0.032 points, respectively). Over time, cognitive composite (by .103 points every 6 months) and all domain specific subscores showed subtle worsening in non-diabetics, but diabetics had significantly slower worsening than non-diabetics on both cognitive composite (by 0.028 points) and domain specific subscores. Discussion Among elders, diabetes may be associated with lower cognitive performance, primarily in non-memory domains. However it is not associated with continued worsening, suggesting a static deficit with minimal memory involvement. This data suggest that diabetes may contribute more to a vascular profile of cognitive impairment than a profile more typical of AD.

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“…Podría pues afirmarse que mientras que en el joven y el adulto la diabetes mata, en el anciano discapacita. Este hecho hace que la detección del deterioro funcional en estos pacientes sea un componente fundamental de la valoración de estos pacientes, que debiera incluir la presencia de síndromes geriátricos frecuentemente interrelacionados como las caídas, el deterioro cognitivo, la depresión y la incontinencia urinaria, lo cual nos obliga a estar alertas en su prevención y tratamiento 15,16 , así como el riesgo de hipoglucemias.…”

Section: Características Clínicas Diferenciales De La Diabetes Mellitunclassified

Características diferenciales de la diabetes mellitus tipo 2 en el paciente anciano. Papel de los inhibidores de la dipeptidil peptidasa 4

Formiga

Gómez‐Huelgas

Rodríguez‐Mañas

2016

Revista Española de Geriatría y Gerontología

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Diabetes Mellitus as a Risk Factor for Functional and Cognitive Decline in Very Old People: The Octabaix Study

Cited by 40 publications

References 18 publications

The emergence of frailty and sarcopaenia in diabetes mellitus: description of inter-relationships and clinical importance

The emergence of frailty and sarcopaenia in diabetes mellitus: description of inter-relationships and clinical importance

Longitudinal Cognitive Profiles in Diabetes: Results From the National Alzheimer's Coordinating Center's Uniform Data

Características diferenciales de la diabetes mellitus tipo 2 en el paciente anciano. Papel de los inhibidores de la dipeptidil peptidasa 4

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