Introduction: The authors describe the main histopathological findings in a serious case of schistosomiasis. Methods: the study was based on the histological analysis of fragments from organs of a 26-year-old patient. Results: the necropsy revealed the association of forms: hepatosplenic, cardiovascular, and chronic miliary with eggs found in the glomerulus afferent arteriole and the rare association of locations in the myocardium, kidney, and pancreas.