Diabetes Mellitus and Polycystic Ovary Syndrome: Beyond A Dermatological Problem

Abstract

Background and aim: Polycystic ovarian syndrome is a common endocrine disorder in reproductive age, with unknown etiology and a variable clinical presentation. Recognizing polycystic ovary syndrome in women presenting with oligo-ovulation and hyperandrogenism offers an important opportunity to begin a life-long conversation about prevention and treatment of a condition that has a multi-system impact on affected women. Recognition offers the chance for providers and patients to engage in discussions about prevention and early treatment of metabolic derangements. This review aims to review the polycystic ovarian syndrome and the approach to the metabolic complications such as insulin resistance and associated hyperinsulinemia.

Dermatologic Toxicities and Biological Activities of Chromium

“…Acne vulgaris is a common dermatological condition that affects physical and psychological aspects of patients [116]. Several diseases that show the presence of a certain degree of acne also relate with depression and emotional stress such as type-2 diabetes, rheumatoid arthritis, and polycystic ovarian syndrome (PCOS) [117][118][119]. Pathophysiology of this disease involves several key mechanisms including excessive sebum production due to hormonal and environmental conditions, alteration of fatty acids composition due to sebum metabolism by Cutibacterium acnes, hyperkeratinization within the follicle that clogs up the pore in the form of whitehead or blackhead comedones, inflammation induced by bacterial colonization, and malfunction of locale innate and adaptive immune system [120].…”

Trace Metals in the Environment - New Approaches and Recent Advances

“…The particle smaller than 10 μm is called PM 10, while PM 2.5 stand for that smaller than 2.5 μm. It is obviously that the haze-day rate has increasing in the past decade, several researchers have reported characteristics, composition, and sources of PM 10 and PM 2.5 in some Chinese cities [17,64,117]. At the same time, PM 10 and PM 2.5 in megacities all around the world are investigated [118][119][120][121].…”