Diabetes mellitus and incidence and mortality of kidney cancer: A meta-analysis

Bao, Cuiping; Yang, Xilin; Xu, Weili; Luo, Huimin; Xu, Zhongliang; Su, Cheng; Qi, Xiaojuan

doi:10.1016/j.jdiacomp.2013.01.004

Cited by 82 publications

(58 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Future studies are needed to investigate associations by subtypes of cancer and to explore whether other sex-specific risk differences, such as in the pattern and extent of alcohol drinking, can explain the difference by sex. Evidence of the association between diabetes and kidney cancer, thyroid cancer and lymphoma has also been inconsistent, although meta-analyses have suggested positive associations between diabetes and these cancers [43–45]. Two cohort studies in Asians reported a statistically significant increase in the risk of thyroid cancer incidence or mortality among diabetic patients [10, 13].…”

Section: Discussionmentioning

confidence: 99%

Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium

et al. 2017

View full text Add to dashboard Cite

Aims/hypothesis The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. Methods Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium, comprising data from 658,611 East Asians and 112,686 South Asians. HRs were used to compare individuals with diabetes at baseline with those without diabetes for the risk of death from any cancer and from site-specific cancers, including cancers of the oesophagus, stomach, colorectum, colon, rectum, liver, bile duct, pancreas, lung, breast, endometrium, cervix, ovary, prostate, bladder, kidney and thyroid, as well as lymphoma and leukaemia. Results During a mean follow-up of 12.7 years, 37,343 cancer deaths (36,667 in East Asians and 676 in South Asians) were identified. Baseline diabetes status was statistically significantly associated with an increased risk of death from any cancer (HR 1.26;95% CI1.21, 1.31). Significant positive associations with diabetes were observed for cancers of the colorectum(HR 1.41;95% CI 1.26, 1.57), liver (HR 2.05;95% CI 1.77, 2.38), bile duct (HR 1.41;95% CI 1.04, 1.92), gallbladder (HR 1.33; 95% CI1.10, 1.61), pancreas (HR 1.53; 95% CI1.32, 1.77), breast (HR 1.72; 95% CI1.34, 2.19), endometrium (HR 2.73; 95% CI1.53, 4.85), ovary (HR 1.60; 95% CI1.06, 2.42), prostate (HR 1.41; 95% CI1.09, 1.82), kidney (HR 1.84; 95% CI1.28, 2.64) and thyroid (HR 1.99; 95% CI1.03, 3.86), as well as lymphoma (HR 1.39; 95% CI1.04, 1.86). Diabetes was not statistically significantly associated with the risk of death from leukaemia and cancers of the bladder, cervix, oesophagus, stomach and lung. Conclusions/interpretation Diabetes was associated with a 26% increased risk of death from any cancer in Asians. The pattern of associations with specific cancers suggests the need for better control (prevention, detection, management) of the growing epidemic of diabetes (as well as obesity), in order to reduce cancer mortality.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium

et al. 2017

View full text Add to dashboard Cite

show abstract

“…[10] Systematic reviews and meta-analyses have already evaluated the risk of cancer incidence at different sites. [11–15] A previous study indicated that women with DM have a moderately increased risk of developing ovarian cancer. [16] However, traditional case–control studies were included in the previous study, which are less strong than cohort studies, and the findings of stratified analyses were affected by differences in study design.…”

Section: Introductionmentioning

confidence: 99%

Association between diabetes mellitus and subsequent ovarian cancer in women

Wang

Zhang

et al. 2017

Medicine

View full text Add to dashboard Cite

Epidemiologic studies have suggested that diabetes mellitus (DM) might be associated with risk of ovarian cancer; however, the results have been inconsistent. The aim of this study was to determine the relationship between DM and the incidence of ovarian cancer on the basis of cohort studies.Relevant studies from PubMed, Embase, and the Cochrane Library until September 2016 were collected. The summary risk ratio (RR) was used as the effect measure in a random effects model. Sensitivity analysis, subgroup analysis, and calculation of publication bias were conducted.Thirteen articles including 14 cohorts comprising a total of 3708, 313 women and reporting 5534 cases of ovarian cancer were included. The summary RR suggested that patients with DM had a higher risk of ovarian cancer than patients without DM (RR: 1.19; 95% confidence interval: 1.06–1.34; P = .004), and no evidence of publication bias was found. The subgroup analysis indicated a higher incidence of ovarian cancer in patients with DM in studies published after 2010, studies not conducted in Europe or the United States, studies that did not adjust for body mass index or smoking status, and studies with lower Newcastle–Ottawa Scale scores.The present findings indicated that DM is a risk factor for ovarian cancer, and future large-scale epidemiologic studies should be performed to evaluate this relation in specific populations.

show abstract

“…The main hallmarks of T2D are high blood glucose (Basu et al, 2004;National Diabetes Data Group, 1979), glucagon (D'Alessio, 2011) and insulin (Martin et al, 1992;Weyer et al, 1999) levels among other factors. T2D also increases the risk of liver disease (such as steatosis) (Papa et al, 2009;Wang et al, 2012), heart disease (Chow et al, 2000), diabetic retinopathy (Barber, 2003) and kidney failure (Bao et al, 2013;Russo, 2012).…”

Section: Introductionmentioning

confidence: 99%

Glucagon phosphorylates serine 552 ofβ-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver

Chowdhury

Montgomery

Morris

et al. 2015

Archives of Physiology and Biochemistry

View full text Add to dashboard Cite

In the last 20 years the prevalence of metabolic disorders, in particular type 2 diabetes (T2D), has more than doubled. Recently, a strong link between T2D and cancer, in particularly liver cancer has been reported. However, the mechanism connecting the development of type 2 diabetes and cancer remains unknown. One of the biggest drivers of liver cancer is alterations in the Wnt/β-catenin pathway. In this study, we aimed to identify the effect of glucagon on β-catenin in the isolated rat liver. We found glucagon, which is substantially raised in patients with T2D, rapidly phosphorylates β-catenin on serine 552 that is associated with increased expression of genes cyclin D1 (CCND1) and c-Myc (MYC), which are known to be involved in liver cancer. This finding may explain the increased risk of liver cancer in people with T2D.

show abstract

Diabetes mellitus and incidence and mortality of kidney cancer: A meta-analysis

Cited by 82 publications

References 54 publications

Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium

Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium

Association between diabetes mellitus and subsequent ovarian cancer in women

Glucagon phosphorylates serine 552 ofβ-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver

Contact Info

Product

Resources

About