1997
DOI: 10.1016/s0002-8703(97)70245-x
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Diabetes mellitus and echocardiographic left ventricular function in free-living elderly men and women: The Cardiovascular Health Study

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Cited by 150 publications
(104 citation statements)
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“…2,5 Consequently, investigators have examined the relations of lesser degrees of glucose intolerance and insulin resistance to LV structure. 8 -13 Prior studies are limited by small samples, sex-pooled analyses, and inadequate adjustment for key confounders (BP and BMI) in multivariable analyses.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…2,5 Consequently, investigators have examined the relations of lesser degrees of glucose intolerance and insulin resistance to LV structure. 8 -13 Prior studies are limited by small samples, sex-pooled analyses, and inadequate adjustment for key confounders (BP and BMI) in multivariable analyses.…”
Section: Discussionmentioning
confidence: 99%
“…LV hypertrophy has been associated with diabetes mellitus and abnormal glucose tolerance in several epidemiological investigations. [2][3][4][5] Furthermore, LV hypertrophy is a feature of several endocrinopathies characterized by insulin resistance. 6,7 Consequently, several investigators 8 -13 have evaluated the relations of insulin resistance to LVM.…”
mentioning
confidence: 99%
“…8 Patients with type 2 diabetes also have increased left ventricular mass, itself an important and independent predictor of outcome, 9 compared with non-diabetic patients, even after correction for peripheral blood pressure. 10 Increased stiffness, augmenting central systolic pressure may explain this finding, and may provide one potential mechanism by which diabetes predisposes to cardiovascular disease. However, whether measurement of arterial stiffness will prove to be a better predictor of cardiovascular risk than simply assessing pulse pressure at the brachial artery remains unclear, and the results of large-scale outcome studies are awaited.…”
Section: Introductionmentioning
confidence: 99%
“…For example, increased LVM increases the risk of myocardial infarction and heart failure by enhancing myocardial oxygen consumption and by impeding diastolic left ventricular compliance. Several studies have shown that deteriorating glucose tolerance is associated with increased LVM (5)(6)(7)(8)(9)(10)(11)(12)(13)(14). The mechanisms responsible for this association remain unclear, but hyperglycemia/-insulinemia and the insulin-resistant state have been implicated in the pathogenesis of increased LVM (14 -18).…”
mentioning
confidence: 99%