Diabetes mellitus and cancer risk in a population‐based case–controlstudy among men from Montreal, Canada

Abstract

Diabetics may have a higher risk of cancer, notably liver and pancreatic cancers. Evidence about other cancer types remains sparse. The authors examined potential associations between diabetes and several types of cancer in a large multicancer case-control project carried out in Montreal, Canada, in the 1980s. This report, based on 3,107 male cancer cases and 509 population controls, uses information on diabetes and several covariates collected by interview. Adjusted odds ratios (ORs) and 95% confidence intervals (CI) were estimated for the associations between diabetes and each of 12 cancer types. Risks of pancreatic and liver cancers were increased among diabetics: adjusted ORs were 2.1 (95% CI: 1.0, 4.3) for pancreatic and 3.1 (95% CI: 1.1, 8.8) for liver cancer. The increased risk of pancreatic cancer was completely restricted to those with recent onset of diabetes; this was likely a manifestation of reverse causality. Conversely, the increased risk of liver cancer was independent of the interval between diabetes and cancer diagnoses. No associations were observed with melanoma, nonHodgkin's lymphoma, cancers of the esophagus, stomach, colon, rectum, lung, prostate, bladder and kidney. In conclusion, diabetes was associated with an increased risk of liver cancer among men, but with no other cancer type including pancreatic cancer. ' 2005 Wiley-Liss, Inc.

Diabetes Mellitus Increases the Risk of Bladder Cancer: An Updated Meta-analysis

“…To date, many large sample epidemiological studies have investigated the important role of DM in bladder cancer development. The results were inconsistent or even contradictory, some of studies did not support an association of DM with overall bladder cancer incidence (Rousseau et al, 2006;Larssona et al, 2008;Zhang et al, 2012). So after removing the three unqualified literature (Kessler, 1970;Kantor et al, 1984;Verlato et al, 2003), adding the new studies which were not included in above meta-analysis, we performed a meta-analysis of 23 published studies covering 643,683 cases and 4,819,656 controls to get a more precise evaluation of the association between DM and the risk of bladder cancer.…”

“…However there were still some limitations in this published meta-analysis: (1) The studies and samples were insufficient for which did not contained many new studies with a large number of samples which reported in recent years (Manami et al, 2006;Rousseau, 2006;Susanna et al, 2008;Li et al, 2011;MacKenzie et al, 2011;Tseng, 2011;Attner et al, 2012;Zhang et al, 2012;Newton et al, 2013;Prizment et al, 2013). So the population included in it was too small to reveal the actual relationship between DM and the bladder cancer risk.…”

“…Twenty three relevant studies were retrieved about incidence, including eight case-control studies (O'Mara et al, 1985;Risch et al, 1988;Vecchia et al, 1994;Kravchick et al, 2001;Ng et al, 2003;Rousseau et al, 2006;MacKenzie et al, 2011;Attner et al, 2012), fifteen cohort studies (Ragozzino et al, 1982;Adami et al, 1991;Wideroff et al, 1997;Tripathi et al, 2002;Zendehdel et al, 2003;Coughlin et al, 2004;Swerdlow et al, 2005;Jee et al, 2005;Inoue et al, 2006;Larssona et al, 2008;Li et al, 2011;Tseng et al, 2011;Zhang et al, 2012;Newton et al, 2012;Prizment., 2013), comprising a total of 643,683 patients with DM and 4,819,656 patients without DM. The characteristics of selected studies are summarized in Table 1.…”

“…The characteristics of selected studies are summarized in Table 1. In some studies, the integral number of male and female were not reported (O'Mara et al, 1985;Risch et al, 1988;Kravchick et al, 2001;Ng et al, 2003;Inoue et al, 2006;Rousseau et al, 2006;Attner et al, 2012;Prizment et al, 2013;Verlato et al, 2013), and two of them were only included with women (Tripathi et al, 2002;Prizment et al, 2013), also another two of them were only included with men (Larssona et al, 2008;Attner et al, 2012), so there were 279,508 male and 291,644 female patients with DM, 2,199,602 male and 1,742,232 female patients without DM, respectively. There were ten studies with North America region, eight for Europe region and five with Asia region, respectively.…”

DNA aptamer raised against advanced glycation end products inhibits melanoma growth in nude mice

“…[1][2][3][4][5] In the Västerbotten Intervention Project of northern Sweden, total cancer risk in women increased with rising plasma levels of fasting and postload glucose, up to a relative risk for the top versus bottom quartile of 1.26 and 1.31, respectively. 1 Risk of cancer of the pancreas, endometrium, urinary tract and of malignant melanoma was statistically significantly associated with high fasting glucose, which was totally independent on age, smoking and body mass index.…”