Diabetes mellitus: an important risk factor for peripheral vascular disease

Giannopoulos, Stefanos; Armstrong, Ehrin J.

doi:10.1080/14779072.2020.1736562

Cited by 14 publications

(8 citation statements)

References 93 publications

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“… 4 , 5 The presence of these comorbidities carries a substantially poorer prognosis, suggesting a likelihood of an additive adverse impact of diabetes and vascular disease on overall prognosis. 6 , 7 , 8 The aim of this population cohort study is to establish the incidence rates of major adverse cardiovascular events (MACE), cardiac and all-cause mortality in kidney, and simultaneous pancreas−kidney (SPK) transplant recipients with functioning allografts at 12-months posttransplantation, stratified according to the presence and absence of diabetes and vascular disease using administrative healthcare databases (held at ICES, Toronto, Ontario, Canada). These datasets were linked using unique encoded identifiers and analyzed at ICES.…”

mentioning

confidence: 99%

Incidence of Major Adverse Cardiovascular Events and Cardiac Mortality in High-Risk Kidney-Only and Simultaneous Pancreas−Kidney Transplant Recipients

Lim

Kim

Knoll

et al. 2021

Kidney International Reports

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mentioning

confidence: 99%

Incidence of Major Adverse Cardiovascular Events and Cardiac Mortality in High-Risk Kidney-Only and Simultaneous Pancreas−Kidney Transplant Recipients

Lim

Kim

Knoll

et al. 2021

Kidney International Reports

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“…Chronic limb-threatening ischemia represents the end stage of atherosclerotic PAD [4,5] inasmuch as diabetes mellitus remains as an important risk factor for atherosclerotic disease. Despite successful pharmacological interventions and educational programs PAD still contributes alarming limb amputation and early mortality figures [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Intralesional Infiltrations of Arteriosclerotic Tissue Cells-Free Filtrate Reproduce Vascular Pathology in Healthy Recipient Rats

Berlanga‐Acosta

Fernández‐Mayola

Mendoza‐Marí

et al. 2022

IJMS

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Lower-extremity arterial disease is a major health problem with increasing prevalence, often leading to non-traumatic amputation, disability and mortality. The molecular mechanisms underpinning abnormal vascular wall remodeling are not fully understood. We hypothesized on the existence of a vascular tissue memory that may be transmitted through soluble signaling messengers, transferred from humans to healthy recipient animals, and consequently drive the recapitulation of arterial wall thickening and other vascular pathologies. We examined the effects of the intralesional infiltration for 6 days of arteriosclerotic popliteal artery-derived homogenates (100 µg of protein) into rats’ full-thickness wounds granulation tissue. Animals infiltrated with normal saline solution or healthy brachial arterial tissue homogenate obtained from traumatic amputation served as controls. The significant thickening of arteriolar walls was the constant outcome in two independent experiments for animals receiving arteriosclerotic tissue homogenates. This material induced other vascular morphological changes including an endothelial cell phenotypic reprogramming that mirrored the donor’s vascular histopathology. The immunohistochemical expression pattern of relevant vascular markers appeared to match between the human tissue and the corresponding recipient rats. These changes occurred within days of administration, and with no cross-species limitation. The identification of these “vascular disease drivers” may pave novel research avenues for atherosclerosis pathobiology.

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“…In the same year, the number of deaths from heart disease reached 32,347 per 100,000 people, and the number of deaths from cerebrovascular disease reached 21,860 per 100,000 people [ 1 ]. Diabetes mellitus is a dangerous disease that in itself leads to death, but it is also a disease that requires management as a risk factor that leads to death from cardio-cerebrovascular disease because diabetes acts as a risk factor for the occurrence of cardio-cerebrovascular disease [ 2 , 3 , 4 , 5 ]. Several studies have found a socioeconomic gradient in diabetes risk variables.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Neighborhood Deprivation on Mortality in Newly Diagnosed Diabetes Patients: A Countrywide Population-Based Korean Retrospective Cohort Study, 2002–2013

Cho

Kim

Choi

et al. 2022

IJERPH

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Background: Neighborhood environmental factors along with individual factors are beginning to make a mark as factors which influence individual health outcomes. The goal of this study is to look at the combined impact of individual and neighborhood socioeconomic status on all-cause mortality in diabetic patients who have just been diagnosed. Methods: The Korean National Health Insurance (2002–2013) was employed in this cohort research, which used a stratified random sample. During the years 2003–2006, a total of 15,882 individuals who were newly diagnosed with diabetes and using oral disease-controlling medication were included in the study. Individual income and neighborhood deprivation index were used to examine the combined effect on all-cause mortality. The frailty model was performed using Cox’s proportional hazard regression. Results: During the study period, 28.3 percent (n = 4493) of the 15,882 eligible individuals died. In a Cox regression analysis after adjusting for all covariates, with advantaged and disadvantaged neighborhoods classified according to individual household income, the adjusted HR for patients living in a disadvantaged area was higher compared to patients living in an advantaged area in patients with middle income, compared to the reference group (a high income within an advantaged neighborhood) (HR, 1.22; 95% CI, 1.09–1.35; HR, 1.13; 95% CI, 1.02–1.25, respectively). The adjusted HR for patients with low income who lived in a disadvantaged location was greater than for patients who lived in an advantaged area (HR, 1.34; 95% CI, 1.18–1.53 vs. HR, 1.28; 95% CI, 1.14–1.49). Conclusions: Individual SES has a greater impact on all-cause mortality among diabetic patients when they live in a low-income neighborhood.

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Diabetes mellitus: an important risk factor for peripheral vascular disease

Cited by 14 publications

References 93 publications

Incidence of Major Adverse Cardiovascular Events and Cardiac Mortality in High-Risk Kidney-Only and Simultaneous Pancreas−Kidney Transplant Recipients

Incidence of Major Adverse Cardiovascular Events and Cardiac Mortality in High-Risk Kidney-Only and Simultaneous Pancreas−Kidney Transplant Recipients

Intralesional Infiltrations of Arteriosclerotic Tissue Cells-Free Filtrate Reproduce Vascular Pathology in Healthy Recipient Rats

The Effect of Neighborhood Deprivation on Mortality in Newly Diagnosed Diabetes Patients: A Countrywide Population-Based Korean Retrospective Cohort Study, 2002–2013

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