Diabetes mellitus

Jiménez, Patricia Gallardo; Martín-Carmona, Jesica; Hernandez, Éric

doi:10.1016/j.med.2020.09.010

Cited by 17 publications

(13 citation statements)

References 8 publications

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“…At the preliminary stage, the population is initialized and the fitness of the population is calculated. The maximum fitness of each particles is compared with the best found so far as given in (1).…”

Section: Go To Step 12mentioning

confidence: 99%

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Elasticity Based Med-Cloud Recommendation System for Diabetic Prediction in Cloud Computing Environment

Ateeq¹,

Pradhan²,

Mago³

2020

Adv. sci. technol. eng. syst. j.

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Section: Go To Step 12mentioning

confidence: 99%

“…Diabetes is a chronic disease that begins with the failure of pancreas. The pancreas fails to produce sufficient insulin required by the body [1]. The internal changes prompt to an increased concentration of glucose in the blood.…”

Section: Introductionmentioning

confidence: 99%

Elasticity Based Med-Cloud Recommendation System for Diabetic Prediction in Cloud Computing Environment

Ateeq¹,

Pradhan²,

Mago³

2020

Adv. sci. technol. eng. syst. j.

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Section: Introductionmentioning

confidence: 99%

“…Diabetes is a metabolic condition categorized by malfunction of glucose metabolism [1]. It leads to other complications like cardiovascular, peripheral, vascular, ocular, neurologic and renal abnormalities etc [1,2]. The growing problem of diabetes has led to integrated research activities globally for the development of defensive and therapeutic strategies [1,3].…”

Section: Introductionmentioning

confidence: 99%

“…It leads to other complications like cardiovascular, peripheral, vascular, ocular, neurologic and renal abnormalities etc [1,2]. The growing problem of diabetes has led to integrated research activities globally for the development of defensive and therapeutic strategies [1,3]. The World Health Organization (WHO) has estimated that ~1.6 and 2.5 million people may die from diabetes in 2015 and 2030 respectively [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Designing of some Novel Methyl 2-((4-(Benzamido)Phenyl)Sulfanyl)-1,2,3,4-tetrahydro-6-Methylpyrimidine-5-carboxylate Derivatives as Potential Glucokinase Activators through Molecular Docking

Kazi¹,

Chatpalliwar²

2021

JPRI

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Aims: Glucokinase (GK) is a cytoplasmic enzyme that metabolizes the glucose to glucose- 6-phosphate and supports the adjusting of blood glucose levels within the normal range in humans. In pancreatic β-cells, it plays a leading role by governing the glucose-stimulated secretion of insulin and in liver hepatocyte cells, it controls the metabolism of carbohydrates. GK acts as a promising drug target for the treatment of patients with type 2 diabetes mellitus (T2DM). Study Design: In the current study, the goal is to identify new substituted benzamide derivatives and test them via molecular docking as possible anti-diabetic drugs. Place and Duration of Study: The present work has been carried out at S.N.J.B’s S.S.D.J. College of Pharmacy, Neminagar, Chandwad, Nashik, Maharashtra, India during the time period of December-2020 to February-2021. Methodology: This work involved designing novel methyl 2-((4-(benzamido)phenyl)sulfanyl)-1,2,3,4-tetrahydro-6-methylpyrimidine-5-carboxylate derivatives and their screening by molecular docking studies to determine the binding interactions for the best-fit conformations in the binding site of the GK enzyme. Autodockvina 1.1.2 in PyRx 0.8 was used to perform the docking studies of all the designed novel derivatives and native ligand against the crystal structure of GK. Based on the results of docking studies, the selected molecules will be tested for their antidiabetic activity in the animal models. Results: Amongst the designed derivatives, compounds A2, A3, A8, A10, A11, A13, A14, A16, A17, and A18 have shown better binding free energy (between -8.7 to -10.3 kcal/mol) than the native ligand present in the enzyme structure. In present investigation, many molecules had formed strong hydrogen bond with Arg-63 which indicate the potential to activate GK. Conclusion: From above results it has been observed that these designed benzamide derivatives have potential to activate the human GK which enables us to proceed for the syntheses of these derivatives.

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The therapeutic potential of “Crataegus azarolus” on zinc, lipid profile, and antioxidant status in streptozotocin-induced diabetic rats with zinc-deficient diet

Triki,

Boughediri,

Chelaghmia

et al. 2023

Comp Clin Pathol

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Diabetes mellitus

Cited by 17 publications

References 8 publications

Elasticity Based Med-Cloud Recommendation System for Diabetic Prediction in Cloud Computing Environment

Elasticity Based Med-Cloud Recommendation System for Diabetic Prediction in Cloud Computing Environment

Designing of some Novel Methyl 2-((4-(Benzamido)Phenyl)Sulfanyl)-1,2,3,4-tetrahydro-6-Methylpyrimidine-5-carboxylate Derivatives as Potential Glucokinase Activators through Molecular Docking

The therapeutic potential of “Crataegus azarolus” on zinc, lipid profile, and antioxidant status in streptozotocin-induced diabetic rats with zinc-deficient diet

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