Diabetes is associated with lower tuberculosis antigen-specific interferon gamma release in Tanzanian tuberculosis patients and non-tuberculosis controls

Abstract

Diabetes is associated with lower levels of Mtb antigen-specific IFN-γ, and the validity of IFN- γ tests for LTBI may be questionable in individuals with diabetes.

Risk factors for false-negative T-SPOT.TB assay results in patients with pulmonary and extra-pulmonary TB

“…64 However, in our study, we did not detect the significant association between diabetes and false-negative T-SPOT.TB result in both pulmonary TB and extra-pulmonary TB. Our result was consistent with Gan et al' study that they also found no significant differences in the qualitative or quantitative T-cell IFN-g response to MTB-specific antigens as measured by QFT and T-SPOT.TB assays between diabetic and non diabetic patients with culture-confirmed TB patients.…”

The effect of diabetes control status on treatment response in pulmonary tuberculosis: a prospective study

“…The results from this animal study suggest that chronic hyperglycaemia is an offensive condition in TB progression. In addition, a recent human study showed that M tuberculosis -specific IFN-γ was negatively associated with fasting blood glucose levels 22. Another possible explanation is that severe infection may result in significant alterations in glucose metabolism and stress-induced hyperglycaemia.…”

Factors that Predict Negative Results of QuantiFERON-TB Gold In-Tube Test in Patients with Culture-Confirmed Tuberculosis: A Multicenter Retrospective Cohort Study

“…The reported sensitivity of QFT-GIT in diabetic TB patients is variable. Although some studies reported high sensitivity of QFT-GIT in diabetic TB patients [15, 28, 29], a recent study demonstrated a decrease in sensitivity of QFT-GIT in diagnostic TB patients [30]. Some of the proposed causes of the high incidence of indeterminate results include delayed M .…”