Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone in Critically Ill Patients

Harrois, Anatole; Anstey, James

doi:10.1016/j.ccc.2018.11.001

Cited by 21 publications

(20 citation statements)

References 68 publications

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“…Our patient had a history of CDI and desmopressin use. If desmopressin had not been used, serum sodium would have been elevated (5). However, the serum sodium level was decreased in our patient.…”

Section: Discussionmentioning

confidence: 57%

Sodium valproate in association with hyponatremia and syndrome of inappropriate secretion of antidiuretic hormone: a case report

Örüm

2020

Journal of Health Sciences and Medicine

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Section: Discussionmentioning

confidence: 57%

Sodium valproate in association with hyponatremia and syndrome of inappropriate secretion of antidiuretic hormone: a case report

Örüm

2020

Journal of Health Sciences and Medicine

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“…However, the discrepancy in the DPN detection rate was not observed in the high-normal serum sodium group and the hypernatremia group. No survival advantage was noted once the serum sodium reached 145 mmol/L [47], and hypernatremia might cause other chronic diseases and more serious public health problems [48].…”

Section: Journal Of Diabetes Researchmentioning

confidence: 99%

Relationship between Hyponatremia and Peripheral Neuropathy in Patients with Diabetes

Zhang

Huang

et al. 2021

Journal of Diabetes Research

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Objectives. Hyponatremia is a common complication of diabetes. However, the relationship between serum sodium level and diabetic peripheral neuropathy (DPN) is unknown. This study was aimed at investigating the relationship between low serum sodium level and DPN in Chinese patients with type 2 diabetes mellitus. Methods. A retrospective study was performed on 1928 patients with type 2 diabetes between 2010 and 2018. The multivariate test was used to analyze the relationship between the serum sodium level and the nerve conduction function. A restricted cubic spline was used to flexibly model and visualize the relationship between the serum sodium level and DPN, followed by logistic regression with adjustment. Results. As the serum sodium level increased, the prevalence of DPN had a reverse J-curve distribution with the serum sodium levels (69.6%, 53.7%, 49.6%, 43.9%, and 49.7%; P = 0.001 ). Significant differences existed between the serum sodium level and the motor nerve conduction velocity, sensory nerve conduction velocity, part of compound muscle action potential, and sensory nerve action potential of the participants. Compared with hyponatremia, the higher serum sodium level was a relative lower risk factor for DPN after adjusting for several potential confounders ( OR = 0.430 , 95 % CI = 0.220 – 0.841 ; OR = 0.386 , 95 % CI = 0.198 – 0.755 ; OR = 0.297 , 95 % CI = 0.152 – 0.580 ; OR = 0.376 , 95 % CI = 0.190 – 0.743 ; all P < 0.05 ). Compared with low-normal serum sodium groups, the high-normal serum sodium level was also a risk factor for DPN ( OR = 0.690 , 95 % CI = 0.526 – 0.905 , P = 0.007 ). This relationship was particularly apparent in male participants, those aged <65 years, those with a duration of diabetes of <10 years, and those with a urinary albumin − to − creatinine ratio UACR < 30 mg / g . Conclusions. Low serum sodium levels were independently associated with DPN, even within the normal range of the serum sodium. We should pay more attention to avoid the low serum sodium level in patients with type 2 diabetes mellitus.

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“…While some factors such as the use osmotherapy, the use of fluids with high sodium content, and choice of nutritional preparations are at the discretion of the physician, other factors are trauma-related, such as the occurrence of posterior pituitary dysfunction [17,18]. In the latter case, a deficit in antidiuretic hormone (ADH) secretion results in water loss and hypernatremia, whereas excessive ADH secretion leads to water retention and the risk of hyponatremia [19]. In TBI patients, the prevalence of hyponatremia and hypernatremia has been reported between 15 to 55% [4,13,[20][21][22] and 30 to 50%, [2,23,24] respectively.…”

Section: Relationship With Previous Studiesmentioning

confidence: 99%

Variability in Serum Sodium Concentration and Prognostic Significance in Severe Traumatic Brain Injury: A Multicenter Observational Study

et al. 2020

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Background/Objective: Dysnatremia is common in severe traumatic brain injury (TBI) patients and may contribute to mortality. However, serum sodium variability has not been studied in TBI patients. We hypothesized that such variability would be independently associated with mortality.Methods: We collected 6-hourly serum sodium levels for the first 7 days of ICU admission from 240 severe TBI patients in 14 neurotrauma ICUs in Europe and Australia. We evaluated the association between daily serum sodium standard deviation (dNaSD), an index of variability, and 28-day mortality.Results: Patients were 46 ± 19 years of age with a median initial GCS of 6 [4 -8]. Overall hospital mortality was 28%. Hypernatremia and hyponatremia occurred in 64% and 24% of patients, respectively. Over the first 7 days in ICU, serum sodium standard deviation was 2.8 [2.0 -3.9] mmol/L. Maximum daily serum sodium standard deviation (dNaSD) occurred at a median of 2 [1-4] days after admission. There was a significant progressive decrease in dNaSD over the first 7 days (coefficient -0.15 95%CI [-0.18 --0.12], p<0.001). After adjusting for baseline TBI severity, diabetes insipidus, the use of osmotherapy, the occurrence of hypernatremia and hyponatremia and center, dNaSD was significantly independently associated with 28-day mortality (HR 1.27 95%CI (1.01-1.61), p=0.048).Conclusions: Our study demonstrates that daily serum sodium variability is an independent predictor of 28-day mortality in severe TBI patients. Further prospective investigations are 5 necessary to confirm the significance of sodium variability in larger cohorts of TBI patients and test whether attenuating such variability confers outcome benefits to such patients.

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Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone in Critically Ill Patients

Cited by 21 publications

References 68 publications

Sodium valproate in association with hyponatremia and syndrome of inappropriate secretion of antidiuretic hormone: a case report

Sodium valproate in association with hyponatremia and syndrome of inappropriate secretion of antidiuretic hormone: a case report

Relationship between Hyponatremia and Peripheral Neuropathy in Patients with Diabetes

Variability in Serum Sodium Concentration and Prognostic Significance in Severe Traumatic Brain Injury: A Multicenter Observational Study

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