Diabetes Influences the Cardiac Symptoms Related to Atrial Fibrillation

Sugishita, Kazuro; Shiono, Etsuko; Sugiyama, Takao; Ashida, Takashi

doi:10.1253/circj.67.835

Cited by 32 publications

(25 citation statements)

References 5 publications

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“…16 The additional fact that more patients had DM in the MetS group may have further masked AF symptoms because of potential DM-associated neuropathy. 27 Therefore, this limitation is unlikely to have qualitatively influenced the results presented in this work.…”

Section: Study Limitationsmentioning

confidence: 88%

Metabolic Syndrome and Risk of Recurrence of Atrial Fibrillation After Catheter Ablation

Tang

Dong

Liu

et al. 2009

Circ J

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Section: Study Limitationsmentioning

confidence: 88%

Metabolic Syndrome and Risk of Recurrence of Atrial Fibrillation After Catheter Ablation

Tang

Dong

Liu

et al. 2009

Circ J

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“…Of note, diabetes mellitus may even mask the cardiac symptoms of the firstrecorded episode of AF, possibly because of diabetic neuropathy [24]. One important area may well be the impact of known complications of diabetes mellitus on electrophysiological properties of atrial myocardium and development of AF.…”

mentioning

confidence: 99%

Diabetes mellitus and atrial fibrillation: Perspectives on epidemiological and pathophysiological links

Lip

Varughese

2005

International Journal of Cardiology

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“…14,15) In this study, the CHADS 2 score was also significantly greater in patients with asymptomatic AF than in those with symptomatic AF due to their incidence of diabetes mellitus. According to a subanalysis of the recent AFFIRM study, the percentage of men was lower and the incidence of other complications (including ischemic heart disease, heart failure, peripheral vascular disease, pulmonary disease, and thyroid disease) was lower in patients with asymptomatic AF.…”

Section: )mentioning

confidence: 47%

Efficacy of Antiarrhythmic Drug Therapy in Preventing Recurrence of Atrial Fibrillation and Long-Term Cardiovascular Prognosis in Patients With Asymptomatic Paroxysmal Atrial Fibrillation

et al. 2010

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SummaryWe evaluated the efficacy of antiarrhythmic drug therapy (AAD) and long-term cardiovascular prognosis in patients with asymptomatic paroxysmal atrial fibrillation (AF). This retrospective study included 334 patients (229 men and 105 women, mean age, 69 ± 11 years, mean follow-up, 60 ± 11 months) who were divided into two groups; patients with symptomatic AF (group I) and those with asymptomatic AF (group II) on the basis of subjective symptoms.(1) Actuarial rates of patients without AF recurrence, those with AF recurrence and with electrical/pharmacological cardioversion to restore sinus rhythm, and those with conversion to permanent AF despite AAD were 40%, 41%, and 19%, respectively, in group I, and 22%, 24%, and 54%, respectively, in group II at the end of the followup period. At 60 months, the percentage of patients with conversion to the permanent form of AF was significantly greater in group II than in group I (P < 0.05, group I versus group II). (2) Survival rates free from symptomatic thromboembolism at 36, 60, and 120 months were 96%, 93%, and 88%, in group I, and 82%, 76%, and 71%, respectively, in group II (P < 0.05, group I versus group II). In patients not undergoing anticoagulant therapy, the annual rate of symptomatic thromboembolism was significantly greater in group II (5.3%) than in group I (2.3%) (P < 0.05), while in patients undergoing anticoagulant therapy there was no significant difference in the annual rate of symptomatic thromboembolism between group I (0.9%) and group II (1.8%).The clinical course of asymptomatic paroxysmal AF is refractory to AAD when compared to symptomatic AF, meaning that anticoagulant therapy is required to prevent symptomatic thromboembolism in this group. (Int Heart J 2010; 51: 98-104) Key words: Atrial fibrillation, Prophylactic efficacy, Prognosis, Antiarrhythmic therapy, Ischemic stroke A ccording to a large-scale epidemiological survey performed in Western countries, atrial fibrillation (AF), which is often encountered in daily practice, is an independent risk factor for cardiovascular death, 1) and the risk of such death is 2-3 times higher in patients with AF than in those with sinus rhythm.2) Some patients do not develop any symptoms after the onset of AF, while others may suffer severe restriction of their daily activities even when the episodes of AF are as short as several seconds to a few minutes. Therefore, there are wide individual differences in the symptoms of AF. It has been reported the incidence of asymptomatic AF is 10-40%.3-6) However, the clinical characteristics and prognosis of AF patients have not been elucidated completely in Japan.In this study, we compared asymptomatic AF and symptomatic AF with respect to clinical characteristics, the long-term prophylactic efficacy of antiarrhythmic drug therapy, and cardiovascular survival. MethodsSubjects: The subjects in this study were 334 patients (229 men and 105 women, mean age, 69 ± 11 years) with paroxysmal AF who were monitored at hospital visits every 2-4 weeks and could be observed ...

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Diabetes Influences the Cardiac Symptoms Related to Atrial Fibrillation

Cited by 32 publications

References 5 publications

Metabolic Syndrome and Risk of Recurrence of Atrial Fibrillation After Catheter Ablation

Metabolic Syndrome and Risk of Recurrence of Atrial Fibrillation After Catheter Ablation

Diabetes mellitus and atrial fibrillation: Perspectives on epidemiological and pathophysiological links

Efficacy of Antiarrhythmic Drug Therapy in Preventing Recurrence of Atrial Fibrillation and Long-Term Cardiovascular Prognosis in Patients With Asymptomatic Paroxysmal Atrial Fibrillation

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