Diabetes incidence in an Australian aboriginal population. An 8-year follow-up study.

Daniel, Mark; Rowley, Kevin; McDermott, Robyn; Mylvaganam, A.; O’Dea, Kerin

doi:10.2337/diacare.22.12.1993

Cited by 101 publications

(92 citation statements)

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“…Our finding of overall high prevalence of adverse metabolic profile is consistent with other studies on Australian Indigenous populations. [38][39][40][41] A recent review by Ridker et al 9 suggested that the inclusion of CRP as a component of the metabolic syndrome is timely as it enhances the prognostic properties of the metabolic syndrome as a predictor of CHD events. In contrast, another report suggested that the value of additional information from CRP has been exaggerated by a positive report bias prior to year 2000, confounding the true value of this marker.…”

Section: Discussionmentioning

confidence: 99%

Differential association of C-reactive protein with adiposity in men and women in an Aboriginal community in northeast Arnhem Land of Australia

et al. 2006

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Objective: To examine the relationship between C-reactive protein (CRP), adiposity and other metabolic abnormalities in an Aboriginal community in Northern Australia. Design: Cross-sectional analysis of data obtained between 2001 and 2003 from 379 Aboriginal people residing in a geographically isolated community. Results: Mean (95% CI) CRP in women and men was 4.06 cholesterol (3.53, 4.66) mg/l and 3.42 (2.94, 3.97) mg/l, respectively (P ¼ NS). The prevalence of the metabolic syndrome (US National Education program (NCEP) definition) was significantly higher for women than men (41 vs 18%, w 2 ¼ 20.94, Po0.001). C-reactive protein correlated strongly with adiposity in women (waist circumference, waist to hip ratio and body mass index; rX0.514, Po0.01) but much less strongly in men (rp0.221, Po0.05). In a multivariate stepwise linear regression model, waist circumference was the strongest independent predictor explaining 35% of CRP concentration variance in women, but only 5.4% in men (WHR). Incremental increases in CRP concentration across four BMI categories were significant in women (P linear trend o0.001) but not in men. Conclusions: High CRP levels in the surveyed population are consistent with the high prevalence of vascular disease morbidity and mortality in Aboriginal Australians. The relationship of CRP with increasing body fat was strong and consistent in women but not in men. Prospective studies are needed to elucidate the role of CRP (if any) as a predictive marker for cardiovascular events in this high-risk population.

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Section: Discussionmentioning

confidence: 99%

Differential association of C-reactive protein with adiposity in men and women in an Aboriginal community in northeast Arnhem Land of Australia

et al. 2006

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“…There are, however, two previous studies reporting the incidence of diabetes in high-risk Australians. The incidence of diabetes in Australian Aborigines (24) and in older (aged Ն49 years) Australians from the Blue Mountains Eye Study (25) was 9.9% over 8 years and 9.3% over 10 years, respectively. The data from both of these studies equate to slightly higher incidences than we report here for AusDiab, in keeping with the higher risks of these populations.…”

Section: Incidence Of Diabetesmentioning

confidence: 99%

Glucose Indices, Health Behaviors, and Incidence of Diabetes in Australia

Magliano¹,

Barr²,

Zimmet³

et al. 2008

Diabetes Care

184

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OBJECTIVE -This national, population-based study reports diabetes incidence based on oral glucose tolerance tests (OGTTs) and identifies risk factors for diabetes in Australians.RESEARCH DESIGN AND METHODS -The Australian Diabetes, Obesity and Lifestyle Study followed-up 5,842 participants over 5 years. Normal glycemia, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes were defined using World Health Organization criteria.RESULTS -Age-standardized annual incidence of diabetes for men and women was 0.8% (95% CI 0.6 -0.9) and 0.7% (0.5-0.8), respectively. The annual incidence was 0.2% (0.2-0.3), 2.6% (1.8 -3.4), and 3.5% (2.9 -4.2) among those with normal glycemia, IFG, and IGT, respectively, at baseline. Among those with IFG, the incidence was significantly higher in women (4.0 vs. 2.0%), while among those with IGT, it was significantly higher in men (4.4 04 -3.31]) were associated with incident diabetes. In age-and sexadjusted models, A1C was a predictor of diabetes in the whole population, in those with normal glycemia, and in those with IGT or IFG.CONCLUSIONS -Diabetes incidence is 10 -20 times greater in those with IGT or IFG than those with normal glycemia. Measures of glycemia, A1C, metabolic syndrome components, education level, smoking, and physical inactivity are risk factors for diabetes. Diabetes Care 31:267-272, 2008

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“…25 The western lifestyle implies a larger intake of food with a high glycaemic load 26 and less developed societies adopting the western dietary pattern experience increasing incidences of hyperglycaemia, insulin resistance, hyperinsulinaemia, and type 2 diabetes. 27,28 A high glycaemic load imposes acute and chronic hyperinsulinaemia, 25 and a large intake of sucrose lowers the insulin sensitivity 29 and blocks the binding of insulin to the receptor. 30 Cordain et al 25 argue that high glycaemic load and the resulting hyperinsulinaemia affect different growth factors resulting in scleral growth.…”

Section: Diet and Diabetesmentioning

confidence: 99%